About Dr Shekeeb Mohammad

•Genetic determinants of paediatric movement disorders •Paediatric deep brain stimulation - patient satisfaction, determinants of better outcome and interface with multidisciplinary neurorehabilitation •Neuroimaging of basal ganglia disorders

Shekeeb Mohammad is a paediatric neurologist at the Children’s hospital at Westmead in Sydney who completed his PhD on early recognition of autoimmune encephalitis in Children. His research expertise includes phenotyping, electroencephalography and neuroimaging in the context of childhood onset movement disorders, including genetic and autoimmune movement disorders. He leads the movement disorder clinic, movement disorder genomic testing and paediatric deep brain stimulation services at the Children’s hospital at Westmead.

Shekeeb was funded by the NHMRC and the Petre Foundation during his PhD. His work on describing autoantibody mediated encephalitis after herpes encephalitis in children was amongst the first publications to describe this novel association and the first work to describe the role of multiple antibodies in this condition. This has led to a paradigm shift in understanding and a major change in treatment approach to children who relapse after herpes encephalitis. During his PhD he won the prestigious Winston Churchill fellowship in 2014 and undertook travel to the UK and USA as part of this. His collaborative work with researchers at University college London has led to several landmark co-authored papers including description of a novel treatable genetic condition due to brain manganese deposition (Nature Communications 2016). He is the CI in a research grant "PG01217 "Improvement of care delivery and determining best outcome measures in children with dystonic cerebral palsy undergoing DBS" from Cerebral palsy alliance, Australia. He is interested in global health and as part of this has been working with CSF-Global, a non-governmental organisation in Bangladesh since 2016 supported by a career development fellowship from Cerebral Palsy Alliance into developing a low cost model for care of children with epilepsy and cerebral palsy.

Selected publications

1. Mohammad, S., Paget, S., Dale, R. (2019). Current therapies and therapeutic decision making for childhood-onset movement disorders. Movement Disorders, 34(5), 637-656
2. Mohammad, S., Dale, R. (2018). EEG background activity and extreme delta brush in children with anti-NMDAR encephalitis. European Journal of Paediatric Neurology, 22(1), 207-208. 
3. Mohammad, S., Fung, V., Grattan-Smith, P., Gill, D., Pillai, S., Ramanathan, S., Brilot-Turville, F., Dale, R. (2014). Movement disorders in children with anti-NMDAR encephalitis and other autoimmune encephalopathies. Movement Disorders, 29(12), 1539-1542.
4. Mohammad, S., Sinclair, K., Pillai, S., Merheb, V., Aumann, T., Gill, D., Dale, R., Brilot-Turville, F. (2014). Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-Methyl-D-aspartate receptor or dopamine-2 receptor. Movement Disorders, 29(1), 117-122
5. Mohammad, S., Jones, H., Hong, M., Nosadini, M., Sharpe, C., Pillai, S., Brilot-Turville, F., Dale, R. (2016). Symptomatic treatment of children with anti-NMDAR encephalitis. Developmental Medicine and Child Neurology, 58(4), 376-384
6. Pawela, C., Brunsdon, R., Williams, T., Porter, M., Dale, R., Mohammad, S. (2017). The neuropsychological profile of children with basal ganglia encephalitis: a case series. Developmental Medicine and Child Neurology, 59(4), 445-448
7. Meyer, E., Carss, K., Rankin, J., Nichols, J., Grozeva, D., Joseph, A., Mencacci, N., Papandreou, A., Ng, J., Misra, S., Mohammad, S., Peters, G., Dale, R., et al (2017). Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia. Nature Genetics, 49(2), 223-237
8. Hamdan, F., Myers, C., Cossette, P., Lemay, P., Spiegelman, D., Dionne-Laporte, A., Nassif, C., Diallo, O., Monlong, J., Mohammad, S., et al (2017). High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies. American Journal of Human Genetics, 101(5), 664-685.
9. Danti, F., Galosi, S., Romani, M., Montomoli, M., Carss, K., Raymond, F., Parrini, E., Bianchini, C., McShane, T., Dale, R., Mohammad, S., Shah, U., et al (2017). GNAO1 encephalopathy: Broadening the phenotype and evaluating treatment and outcome. Neurology: Genetics, 3(2), 1-8
10. Tuschl, K., Meyer, E., Valdivia, L., Zhao, N., Dadswell, C., Abdul-Sada, A., Hung, C., Simpson, M., Chong, W., Mohammad, S., Dale, R., et al (2016). Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Nature Communications, 7, 1-16.