About Associate Professor Jon Iredell

Marriage of science and clinical medicine applying modern tools to modern problems

Research Interests: ICU/ Infectious Diseases/ Microbiology/ bacterial genetics

Jon Iredell has comprehensive training in intensive care, infectious diseases and clinical microbiology, combined with a PhD in molecular bacteriology, and contributes ~50% of his time to clinical service.Evidence of his standing in clinical medicine comes from invitations to write chapters in the premier international reference text in Infectious Diseases: Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases Vol. 2. 5th (2001) and 6th (2004) (eds. Mandell, G; Bennett JE and Dolan, R) Elsevier, Churchill-Livingstone, Philadelphia, PA, USA; Control of Communicable Diseases Manual, Australia, 18th ed. (2004); Australasian Anaesthesia (2003); the only Australian textbook of clinical infectious diseases - Infectious Diseases: a clinical approach. eds. Yung A, McDonald M, Spelman D, Street A, Johnson P, Sorrell T, McCormack J. (2004), IP Communications, Melbourne; and the laboratory reference text of the Australian Society for Microbiology, the ASM Antimicrobials Compendium (2004). His research data have been published in top mainstream specialty journals (e.g. J Bacteriol, Gene, Trends in Microbiol, Cell Microbiol, Nature Reviews Microbiology) and top clinical microbiology journals (e.g. Antimicrob Agents Chemother, J Clin Microbiol, Lancet Infect Dis) and presented at a number of national and international meetings.JI's group described the molecular basis for emergent carbapenem resistance in Acinetobacter spp., and was also the first to describe the arrival of transmissible carbapenem resistance genes in this country and its variable phenotype. JI's group successfully applied these discoveries to control outbreaks at Westmead Hospital, and led a team invited by the State Government of Victoria to report on extreme antibiotic resistance in a major ICU in Melbourne in 2004. In work unrelated to this proposal, JI’s group first characterised the genomic diversity of a unique angiogenic intracellular bacterial pathogen (Bartonella henselae), and was involved in the characterisation of the unique intracellular trafficking of that pathogen.JI was the inaugural Division 1 Chair (Medical and Veterinary Microbiology, comprising approximately 60% of the membership) of the Australian Society for Microbiology (2002-2004). Until recently, JI was Chair of the Basic and Clinical Sciences Committee in the Faculty of Medicine and took up the role of Deputy Post-Graduate Coordinator for the Faculty of Medicine (Western), of the University of Sydney, and presently supervises 5 graduate students.

Selected publications

For a comprehensive list of Associate Professor Iredell's publicatons, please visit his Sydney Medical School profile page.