About Dr Lining (Arnold) Ju

I have always been fascinated with the universal forces that make things move and behave the way they do at any scale. My early fascination grew into an intellectual need to explain these phenomena, underpinning my interest in mechanical and biomedical engineering. It was my father’s heart attack in the first year of my PhD, where his blood vessels were occluded by clots, that taught me the shear force of blood flow has a critical effect. I was convinced that my research should solve real-world problems. These days I apply my expertise to understand how some specialised proteins in our blood can actually sense force to enable the development of new treatments and preventative measures that will reduce the loss of life.

Since Darwin's time, the influence of mechanical forces on organisms has been greatly underestimated by researchers. In recent years, more and more cutting-edge studies have shown that external mechanical stimulation has extremely important effects on the fate of cells, tissues and individuals. In decades of studying and working in the US and Australia, I have been committed to solving cardiovascular biomechanics at the single molecule level using mechanical and physics knowledge and engineering techniques. My expertise covers biomechanics, haemorheology and cardiovascular engineering. I have established the innovative 4Ms approach in Australia: Mechanics, Microscopy, Microfabrication & Mouse model by bringing together the fields of biomechanical engineering, imaging, microfluidics and molecular biology. In particular, I have developed the state-of-the-art pico-force (10-12 Newton) nanotool called Biomembrane Force Probe (BFP, >US$500K) as the first of its kind in Australia to study mechanobiology in cardiovascular systems. The cutting-edge 4Ms approach allows me to investigate how haemodynamic force in blood flow regulates platelet thrombotic functions at the Charles Perkins Centre and Heart Research Institute. It allows me to carve out an exciting niche to study thrombotic diseases (such as heart attack and stroke) in a more physiologically relevant environment, leading to new diagnostic and therapeutic applications.

I am an ARC DECRA Fellow, National Heart Foundation Future Leader Fellow and Sydney and Sydney Research Accelerator (SOAR) Fellow. I obtained my bachelor in the No.1 ranked mechanics department at the Peking University, China. Then I received PhD in the top Biomedical Engineering (BME) program with the prestigious SigmaXi Best Thesis honor at the Georgia Institute of Technology and Emory University, USA, where I was mentored by the world leaders in mechanobiology and cardiovascular engineering Prof Cheng Zhu (FAIMBE, FASME) and the US Academy Member Prof Larry V. McIntire (NAE, FAAAS).

In early 2014, I moved to Australia to pursue postdoctoral studies in NHMRC Senior Principal Research Fellow Prof Shaun Jackson’s lab applying mechanobiology approaches to understanding molecular causes of thrombosis in cardiovascular diseases and complications in diabetes.

Since my PhD in 2013-Dec, I have published in world-leading journals including Nature Materials, Nature Communications (x3), eLife (x2), Science Advances, PNAS, Journal of Biological Chemistry, Molecular Biology of the Cell, Blood, and Biophysical Journal across the disciplines of mechanobiology, biomechanical engineering, haematology and cardiovascular diseases.
In the media: Tall Poppy Award and Sir Zelman Cowen Universities Fund Award

Future team building is mainly focused on the development of single-molecule biomechanics, optoelectronic instruments, microfluidics, single-cell biological detection technology, and cross-scientific research in cardiovascular and neurological health and disease. A strong focus is given towards platform implementation, including real-time monitoring of membrane protein receptor dynamics, conformational changes, and simultaneous acquisition of force spectrum and calcium signal on living cells.

Come here and your scientific dream will be realized, your research potentials will be fully stimulated, and there will be no upper limit on your scientific achievements.

Selected publications

# Equal First author; †Corresponding author 
1.    Nature Materials (2019) – Chen Y#, Ju LA#, Zhou F, Liao J, Xue L, Yuan Y, Su QP, Jin D, Lu H, Jackson SP, and Zhu C (2019). An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation. Nature Mat 18(7): 760-769 doi: 10.1038/s41563-019-0323-6 Commented by Nature Materials (18(7):661–662) in the same issue. [IF 39.74] https://www.eurekalert.org/pub_releases/2019-04/uos-rub040319.php https://sydney.edu.au/news-opinion/news/2019/04/02/research-unlocks-biomechanic-mystery-behind-deadly-blood-clots.html https://www.hri.org.au/news/hri-researchers-discover-how-biomechanical-thrombus-growth-is-mediated 
2.    Nature Communications (2018) Ju L, McFadyen JD, Al-Daher S, et al. (2018) Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets. Nature Commun 9(1): 1084. doi: 10.1038/s41467-018-03430-6 [IF 12.53] https://www.hri.org.au/news/blood-clot-breakthrough-a-saviour-for-diabetics 

3.    Nature Communications (2018) – Xu XR#, Wang Y#, Adili R#, Ju L# et al. (2018) Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis. Nature Commun 9(1): 3608 doi: 10.1038/s41467-018-05806-0 [IF 12.53]

4.    eLife (2018) – Passam F, Chiu J, Ju L, Aster P, Jahan Z, Mor-Cohen R, Yeheskel A, Kolšek K, Thärichen L, Aponte-Santamaría C, Gräter F, and Hogg JP (2018) Mechano-redox control of integrin de-adhesion. eLife 7: e34843. doi:10.7554/eLife.34843. [IF 7.62]

5.    Science Advances (2018) – Butera D, Passam F, Ju L, Cook KM, Woon H, Aponte-Santamaría C, Gardiner E, Davis AK, Murphy DA, Bronowska A, Baldauf C, Jackson SP, Andrews R, Gräter F, and Hogg PJ. (2018) Autoregulation of von Willebrand factor function by a disulfide bond switch. Science Advances 4(2): eaaq1477 doi: 10.1126/sciadv.aaq1477. [IF 11.51]   
6.    Scientific Reports (2017) – Ju L†, Chen Y, Li K, et al. (2017) Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species. Sci Rep 7(1): 14185 doi:10.1038/s41598-017-13793-3. [IF 4.12]

7.    eLife (2016) – Ju L, Chen Y, Xue L, Du X, and Zhu C. (2016) Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals. eLife 5: e15447. doi: 10.7554/eLife.15447. Featured in NSF Top Story. [IF 7.62] https://elifesciences.org/interviews/185ceb42/lining-arnold-ju  https://www.news.gatech.edu/2016/08/15/how-mechanical-force-triggers-blood-clotting-molecular-scale   
8.    Nature Communications (2014) – Fiore VF#, Ju L#, Chen Y, Zhu C, and Barker TH. (2014). Dynamic catch of a Thy-1-α5β1+syndecan-4 trimolecular complex. Nature Commun 5: 4886. doi: 10.1038/ncomms5886. [IF 12.53]   
9.    Proc Natl Acad Sci USA (2014) – Choi YI, Duke-Cohan, JS, Chen W, Liu B, Rossy J, Tabarin T, Ju L, Gui J, Gaus K, Zhu C, and Reinherz EL. (2014). Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis. PNAS 111, 379-384. doi: 10.1073/pnas.1314209111. [IF 9.50]

10.  Journal of Biological Chemistry (2013) – Ju L, Dong JF, Cruz MA, and Zhu C (2013). The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ibα. J Bio Chem 288(45): 32289-32301. doi: 10.1074/jbc.M113.504001. [IF 4.60]