About Dr Elham Hosseini-Beheshti

We are leading the effort in understanding a new communication paradigm between cells, which helps in the diagnosis and treatment of many diseases including cancer.

Over the last decade, extracellular vesicles (EV) shed by cancer cells as well as their tumour environment have been established as a very promising source of biomarker and therapeutic target discovery. The research performed in Extracellular Vesicles Biology lab is divided to three main themes: EV in Liquid Biopsy: In contrast to tissue-based biopsy, liquid biopsy has enabled clinicians to examine tumour-derived materials in the circulation which detects changes in tumour burden months or years before conventional imaging tests, making them suitable for early cancer diagnosis. In collaboration with national and international clinicians, the Extracellular Vesicles Biology Lab at USYD is focused on addressing an unmet clinical need to use EV to improve liquid biopsy tools for cancer diagnosis, spread and response to treatment. EV in Tumour Microenvironment: The tumour microenvironment (TME) is an integral part of cancer. EV have demonstrated a pivotal role in modulation of TME, immune response, and metastatic niche formation. Our team is specifically focused on unravelling the role of these nano-sized vesicles in cell-cell communication in TME, and immune TME. EV Isolation and Purification in Clinical Setting: Isolating and purifying EV in clinical setting has remained a major challenge in EV research, our team is planning to develop an integrated workflow for isolation and purification of different EV subtypes using various modern techniques.

Dr. Elham Hosseini-Beheshti is an early career medical scientist and an international emerging leader in EV and cancer research with a decade of experience in investigating the role of EV in various pathological disorders, including different types of cancer. Dr. Beheshti is an iCare Fellow and Head of Extracellular Vesicles Biology Lab at the School of Medical Sciences (SOMS) at the University of Sydney (USYD). She is also an Honorary Visiting Scholar at School of Biomedical Engineering, University of Technology Sydney (UTS). Dr. Beheshti has received her MSc (Food, Nutrition and Health) and PhD (Experimental Medicine) from the University of British Columbia (UBC), Canada. She was selected as the top 5% of PhD students in Canada and nominated as one of Canada's most promising research trainees in health sciences as part of the Canadian Student Health Research Forum. Since joining USYD in 2015, she has initiated and sustained several (inter)national collaborations including with UCLA, UBC, SFU, UM, UNSW, UTS, Westmead and Doherty Institute for studying the role of EV in various immunopathological disorders. She was also identified as one of USYD's talented young researchers in 2017. Dr. Beheshti organized the first national EV workshop in Australia (2019) and was selected as the NSW representative for the Australia and New Zealand Microcirculation Society (2019). She has an established track record in EV, including the largest proteomic summary of prostate cancer derived EV to date. Dr. Beheshti is an active member of International Society for Extracellular Vesicles (ISEV), Australia and New Zealand Society for Extracellular Vesicles (AEVC), American Association for Cancer Research (AACR), Lung Foundation Australia, and Australia and New Zealand Microcirculation Society (ANZMS) and has disseminated her research in many (inter)national conferences as a guest or invited speaker.

She also contributes to the scientific community through her role as an editorial member of several international journals, as well as reviewer for different grant agencies.