About Dr Paul Witting

My chief goal is to understand how oxidants and oxidative stress plays a role in promoting damage to the tissues of the heart and brain during heart attack and stroke.

Dr Witting’s research interest is in exploring the relationship between oxidative stress and the evolution of tissue damage in the acute setting of stroke and myocardial infarct.

Dr Paul Witting is a Senior Lecturer at The University of Sydney and a career biomedical researcher. He has held ARC (2003-2007) and National Heart Foundation Fellowships (1999-2001) that financed post-doctoral terms at the ANZAC Research Institute and University of British Columbia (Canada), respectively. He has a proven track record in the field of bio-medical chemistry publishing 61 peer-reviewed papers (mean impact factor (IF) ~4.6 with >90% appearing in international journals); 4-book chapters; 9-invited review articles and one International Patent. Witting is first or senior author in ~65% of his papers and his work has been acknowledged with 1310 citations (mean citation/publication ~23 yielding an H-index ~23). He has been awarded ~A$3.7 Million in competitive funding from agencies including the ARC, NHF, Wellcome Trust, NHMRC Equipment Grants, The Ramaciotti, Bushell and CASS Foundations, Eli Lilly Diabetes Foundation, Diabetes Australia Research Trust and the University of Sydney Strategic Development Grants Scheme.Witting received his doctorate in 1994 graduating from the School of Chemistry (The University of Sydney) where he specialised in redox chemistry with an emphasis on quantitative analytical assays including HPLC, electrochemistry, mass spectrometry and electron paramagnetic resonance spectroscopy and published 6 papers. Next, he completed a successful post-doctoral appointment with Prof. Roland Stocker (1994-1999) at The Heart Research Institute (hri, Sydney) publishing 16 research papers exploring the impact of oxidative stress in biological systems. He then spent two years with Prof. Grant Mauk (UBC) studying the peroxidase activity of recombinant wild-type and site-directed variants of human myoglobin with a trilogy of ground-breaking publications appearing in the Journal of Biological Chemistry. While at UBC he gained valuable experience in mass spectrometry techniques and this strong basis has provided an impetus to move into other analytical mass spectrometry-based techniques such as combined liquid chromatography and tandem mass spectrometry.In July of 2008 Witting moved from the ANZAC Research Institute to take up a full time Senior Lectureship and establish the Redox Biology Group in the Discipline of Pathology, The University of Sydney. As part of this relocation Witting has been awarded over $175 K in start-up funding that includes a newly renovated laboratory with up-to-date equipment. The new facility combined with significant funding from the Heart Foundation and the ARC over the next 2-3 years provides an excellent environment for young researchers to be trained in biomedical techniques and explore the relationships between oxidative stress and disease.

Selected publications

For a comprehensive list of Dr Witting's publicatons, please visit his Sydney Medical School profile page.