About Professor Andrew McLachlan

Understanding variability in response to inform quality use of medicines in older people

Professor McLachlan is a pharmacist and researcher with experience in clinical pharmacology and research into the Quality Use of Medicines. In 2006 he was appointed Professor of Pharmacy (Aged Care), which is a University of Sydney (Faculty of Pharmacy) position, based at Concord Hospital and the Centre for Education and Research on Ageing (CERA).

Professor McLachlan’s research since the early ‘90s has focused on understanding the causes and consequences of variability in response to medicines and how this can inform their quality use. He has been interested in understanding why particular groups of people respond differently to medicines including older people, young children, people living with cancer, people living with HIV and transplant recipients.  His particular expertise is in the field of clinical and experimental aspects of pharmacokinetics and pharmacodynamics where he has engaged in numerous research-based collaborations, acted as a consultant to the pharmaceutical industry, international universities, served on the Editorial Boards of international peer reviewed journals and been appointed to expert committees of the Australian Government. 

Professor McLachlan has authored over 100 papers in peer reviewed journals and attracted more than $4 million in research funds. He has supervised 15 postgraduate students to successful PhD completion in the last 12 years. Each of the students who has successfully completed his/her degree has subsequently established themselves as an independent research-orientated scientist working in either a leading international university, teaching hospital or in the international pharmaceutical industry.
An example of one of the clinical pharmacology research projects currently underway is to investigating the optimal use of analgesic medicines in older people and how ageing and frailty impact of the clinical pharmacology of analgesic medicines. 

Selected publications

  1. McLachlan AJ, Hilmer SN, Le Couteur DG.  Variability in response to medicines in older people – phenotypic and genotypic factors. Clin Pharmacol Ther  2009; 85(4):431-3.
  2. Hilmer SN, McLachlan AJ, Le Couteur DG.Clinical pharmacology in the geriatric patient. Fundam Clin Pharmacol. 2007;21:217-30.
  3. Jiang X, Williams KM, Liauw W, Ammit AJ, Roufogalis BD, Duke CC, Day RO, McLachlan AJ.  Effect of St John’s wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol 2004 ;57:592-9
  4. Loboz KK, Gross AS, Williams KM, Liauw WS, Day RO, Blievernicht JK, Zanger UM, McLachlan AJ. Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: Effect of induction by rifampin and ethnicity. Clin Pharmacol Ther. 2006;80:75-84.
  5. Xu H, Williams KM, Liauw WS, Murray M, Day RO, McLachlan AJ. Effects of St John's wort and CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of gliclazide. Brit J Pharmacol 2008;153:1579-86. 
  6. Iyer S, Naganathan V, McLachlan A, Le Couteur DG. Medication withdrawal trials in people older than 65 years: a systematic review. Drugs Aging 2008;25:1021-1031.
  7. Nishtala P, Bell JS, McLachlan AJ, Chen TF. Psychotropic Prescribing in Long-Term Care Facilities: Impact of Medication Reviews and Educational Interventions. American Journal of Geriatric Psychiatry 2008;16: 621-632. 
  8. Mohammed Abdul MI, Jiang X, Williams KM, Day RO, Roufogalis BD, Liauw WS, Xu H, McLachlan AJ. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Brit J Pharmacol 2008 ;154:1691-700 
  9. Day RO, Graham GG, Hicks M, McLachlan AJ, Stocker SL, Williams KM. Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. Clin Pharmacokinet. 2007;46:623-44.
  10. Hancock MJ, Maher CG, Latimer J, McLachlan AJ, Cooper CW, Day RO, Spindler MF, McAuley JH. Assessment of diclofenac or spinal manipulation therapy, or both, in addition to standard treatment for acute low back pain: a randomised controlled trial. Lancet 2007; 370(9599):1638-43.