About Professor David Little

Advancing orthopedic care through improved understanding of bone diseases, bone healing and pharmaceutical therapies.

Professor Little is an experienced clinician-researcher with a thriving orthopaedic laboratory based at the Childrens Hospital at Westmead.

Professor Little graduated MBBS from the University of Sydney in 1986. After selection on the Australian Orthopaedic Association training scheme in 1990 Professor Little graduated FRACS(Orth) in 1994. He undertook fellowships in Paediatric Orthopaedics at the Shriners Hospital for Children in Portland, OR, USA and Texas Scottish Rite Hospital for Children in Dallas TX, USA. Professor Little commenced on staff at the Children’s Hospital, Westmead, when it opened in November 1995. In 1998 he began researching the role of bisphosphonates in distraction osteogenesis and in 1999 officially founded Orthopaedic Research and Biotechnology at CHW. Professor Little remains Head of the Unit, and Deputy Head of the Department of Orthopaedics. In 2002 Professor Little was an ABC travelling fellow, presenting his research with other international fellows from UK, NZ and South Africa on a six-week tour of North America. In 2005 Professor Little was awarded his PhD on bisphosphonates in distraction osteogenesis. He has initiated further research on osteonecrosis, fracture healing and the interaction of the anabolic and catabolic responses in bone repair. His lab focuses on exploring basic bone biology via cell culture and animal models and translating developments into pre-clinical and clinical practice. He currently leads a multi-disciplinary team of consisting of clinicians, cell and molecular biologists, histopathologists, and veterinary scientists.

Selected publications

For a comprehensive list of Professor Little's publicatons, please visit his Sydney Medical School profile page.