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A Randomised Controlled Trial of Oxytocin Nasal Spray for Alcohol Dependence

We are conducting research into the effectiveness of a new nasal spray to help with alcohol dependence.

This study aims to assess the efficacy of this nasal spray in reducing alcohol use and craving.

If you participate, you will be asked to complete computer based tasks, questionnaires, neuroimaging and provide blood and urine samples. These assessments will be repeated over five testing sessions.

On the first testing session you will be given either an active nasal spray or a placebo nasal spray, which you will be asked to take twice a day for 12 weeks. You will not know which spray you have received and neither will the researcher.

You will be asked to return for one month and six month follow-up.

Potential benefits to participating in this study include verbal feedback regarding clinical and neuropsychological assessments and neuroimaging, including MRI.

You will be reimbursed for your travel time to participate.

Ethics committee approval number: X17-0110 & HREC/17/RPAH/160


You may be eligible to participate in this study if you:

  • are aged between 18 and 65 years
  • meet criteria for alcohol dependence
  • don't have any severe physical or mental health problems.

How to participate

If you are interested in participating in this study please contact the research team at: or call 9114 4104.