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COLONiC: Consequences of olive Oil replacement on Ulcerative Colitis

Can small dietary changes affect Ulcerative Colitis?
Research has highlighted the role of gut bacteria in influencing health outcomes. This may be especially important in gastrointestinal conditions such as Ulcerative Colitis (UC).

The COLONIC Study aims to assess the role of diet in driving these changes and disease outcomes. We also hope to compare outcomes between those with UC and individuals without UC to better understand disease mechanisms.

This novel 12-week trial involves a health screen and 3 separate visits to the Faculty of Health Science, Lidcombe. During this time we will collect blood and stool samples, and you will be asked to complete food diaries and questionnaires.

You will then be randomized to either an intervention or a monitoring group. Participants in the intervention will receive extra virgin olive oil over a 4-week period. During this time, you will be asked to replace all your cooking oils and fats with the replacement oil. Participants in both groups will be supported by a team of qualified health professionals for the duration of the study. 

Ethics committee approval number: 2018/981 


We are recruiting for two groups of participants:
1) Individuals living with Ulcerative Colitis (UC), and
2) Individuals with no history of Inflammatory Bowel Disease (IBD)

Eligibility criteria for BOTH groups are:

  • Aged 18-75 years
  • No history of fecal microbial transplant (FMT)
  • No history of major gastrointestinal surgery (appendectomies are permitted)
  • Not currently pregnant or planning for pregnancy in the next 3 months

How to participate

If you are interested to participate in this novel and exciting research, or if you'd like to find out more, please contact Kenneth Daniel ( or 02 9351 9138)