Trevor Hambley Research Group

Dr. Nicole Sarah Bryce



room 412c
School of Chemistry, Building F11,
University of Sydney, NSW, Australia

ph: +61 2 9351 4233
fax: +61 2 9351 3329
bryce_n@chem.usyd.edu.au

Employment

01/2008-Current, Research Associate

School of Chemistry, University of Sydney, NSW, Australia

02/2004-12/2007, Research Fellow

Dept. of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA.

08/2003-01/2004, Postdoctoral Fellow

Dept of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA.

2001-2003, Laboratory Supervisor and Demostrator

University of Western Sydney, Hawkesbury Campus, Richmond, NSW, Australia
Undergraduate laboratory class supervision (up to 60 students), 1st year Biological Science, Semester 1 2003, 1st year Histology, Semester 1 2003

Undergraduate laboratory class demonstration (up to 16 students), 1st year Biological Science, Semester 1, 2001, 2002, 2003, 1st year Microbiology, Semester 2, 2001, 2nd year Nursing Science, Semester 1, 2001.

1998-2003, Research Assistant

Oncology Research Unit, The Children’s Hospital at Westmead, NSW, Australia.



Education

2000-2004, The University of Sydney, NSW, Australia

PhD under the supervision of Dr Ron Weiberger and Prof. Peter Gunning
Thesis title: The roles of Non-Muscle Tropomyosin Isoforms in Neuronal Cells

1994-1997, The University of Sydney, NSW, Australia

B. Sc. (Hons 1) Honours Project under the supervision of Dr Merlin Crossley



Publications

Wang, S.E.**, Hinow, P.**, Bryce, N.S.**, Weaver, A.M., Estrada, L, Arteaga, C.L. and Webb, G.F, A mathematical model quantifies proliferation and motility effects of TGF-β on cancer cells. 2008, Computational and Mathematical Methods in Medicine , 10, 71-83

**indicates equal contribution from the authors

Creed, S.J., Bryce, N.S., Naumanem, P., Weinberger, R., Lappalainen, P., Stehn, J and Gunning, P., Tropomyosin Isoforms define distinct microfilament populations with altered drug susceptibility. 2008, European Journal of Cell Biology, 87, 709-720

Bryce, N., Clark, E., Currie, J., Leysath, J., Webb, D. and Weaver, A.M. , Cortactin Promotes Cell Motility By Enhancing Lamellipodial Protrusions. 2005, Current Biology, 15, 1276-85

Schevzov, G., Bryce, N. S., Almonte-Baldonado, R., Joya, J., Lin, J.J-C., Hardeman, E., Weinberger, R. and Gunning, P. , Specific features of neuronal size and shape are regulated by tropomyosin isoforms 2005, Mol. Biol. Cell , 16, 3425-37

Schevzov, G., Vrhovski, B., Bryce, N.S., Elmir, S., Qiu, M.R., Yang, N., Verrills, N.M., Kavallaris, M. and Gunning, P. , Tissue Specific Isoform Composition 2005, J. Histochem. Cytochem, 53, 557-570

Percival, J. M., Hughes, J. A., Brown, D. L., Schevzov, G., Vrhovski, B., Heimann, K., Bryce, N. S., Stow, J. L. and Gunning, P., Targeting of a tropomyosin isoform to short Golgi-associated microfilaments 2004, Mol. Biol. Cell , 15, 268-80

Bryce, N., Schevzov, G., Ferguson, V., Percival, J., Lin, J., Matsumura, F., Bamburg, J., Jeffrey, P., Hardeman, E., Gunning P. and Weinberger, R., Specification of Actin Filament Function by Tropomyosin Isoforms. 2003, Mol. Biol. Cell , 14, 1002-1016



Fellowships/Scholarships

American Heart Foundation Postdoctoral Fellowship, Southeast Affiliate, July 05-June 07.

National Health and Medical Research Council (Australia), Dora Lush Postgraduate Research Scholarship, 2000-03.



Invited talks

June 2007, Guest Lecture, Cancer Biology Summer Course, Lipscomb University, Nashville, TN, USA



Awards Received

Vanderbilt Ingram Cancer Center – Best Overall Poster, VICC Retreat, 2007

Keystone Symposium Postdoctoral Travel Scholarship, Cell Migration and Adhesion Meeting, 2005

American Society for Cell Biology Predoctoral Travel Award 2002

Best Speaker in Session, University of Sydney, Discipline of Paediatrics and Child Health Postgraduate Student Conference, June, 2002



Professional Memberships

Australian Society for Medical Research
American Association for Cancer Research
American Society for Cell Biology



Selected Conference Abstracts

Bryce, N.S., Zhang, J. Z. and Hambley, T.W. Visualising anti-cancer drug diffusion in a 3-dimensional tumour spheroid model system. Sydney Cancer Conference, Sydney, Australia, 2008

Bryce, N.S., Branch, K.M., Maier, J. and Weaver, A.M. Dynamic actin organization in a 3D cellular system: regulation of cellular adhesion and invasion. Motile and Contractile Systems Gordon Conference, New Hampshire, USA, 2007.

Bryce, N.S. and Weaver, A.M. WAVE-2 regulates epithelial morphology and cadherin switching through a transcriptional mechanism. Recent advances in breast cancer research – Vanderbilt Ingram Cancer Center Retreat, Nashville, USA, 2007.

Creed, S.J., Bryce, N.S., Weinberger, R., Gunning, P. and Stehn, J. Specific Tropomyosin Isoforms Alter The Susceptibility Of Actin Filaments To Actin Altering Drugs. ASCB Annual Meeting, San Diego, USA, 2007.

Clark, E.S., Bryce, N.S. and Weaver, A.M. Cortactin in invadopodia formation. AACR Annual Meeting, Washington DC, USA, 2006.

Gunning, P., Creed, S., Bryce, N., Weinberger, R. and Stehn, J. Tropomyosins regulate the response to actin filaments to cytochalasin and latrunculin. ASCB Annual Meeting, San Francisco, 2005

Bryce, N., Leysath, J., Currie, J., F.B. and Weaver, A.M. Cortactin Promotes Cell Motility By Stabilizing Lamellipodial Protrusions. Cell Migration and Adhesion Keystone Meeting, Snowbird, Utah, USA, 2005

Bryce, N., Leysath, J., Currie, J., F.B. and Weaver, A.M. Cortactin Promotes Cell Motility By Stabilizing Lamellipodial Protrusions. ASCB Annual Meeting, Washington DC, USA, 2004