Natsuho Yamamoto
BSc.(Adv)(Hons)
Highlights
Completed BSc.(Adv)(Hons), graduating with Honours Class I.
Project title: Fluorescent hydroxamic acids as models of cytotoxins in
hypoxia-selective cobalt prodrugs.
Supervisor: Professor Trevor Hambley,
School of Chemistry, University of Sydney
Synthesised hydroxamic acid derivatives of various fluorophores
and complexed them to cobalt(III) in an attempt to use them as intracellular
imaging tools
Education
Doctor of Philosophy (Science) Candidate, Chemistry, University of Sydney, 2007 to present, Supervisor: Professor Trevor Hambley
Bachelor of Science (Advanced) (Hons), Chemistry, University of Sydney
Professional Experience
Post-Graduate Teaching Fellow, School of Chemistry, University of Sydney, 2007 to present.
Teaching first year chemistry students in tutorials, preparing and organising tutorial sessions, aiding students and grading exams
Summer Research Scholarship, School of Chemistry, University of Sydney, Dec 2006 to Feb 2007.
Supervisor: Professor Trevor Hambley
Extra work continued from honour project in order to obtain data for a paper submission
TSP Project, Department of Pharmacology, University of Sydney, Mar 2005 to May 2005.
Supervisor: Associate Professor Robin Allan
Project Title: Exploring reactions of bifenthrin
Priviate Tutoring, 2003 to 2006.
Tutored high school students mainly in Chemistry and Mathematics
Five students ranging from year 7 to 12.
Skills
Experienced researcher with training in inorganic synthesis, nuclear magnetic resonance spectroscopy, cell culture, cytotoxicity assays, confocal microscopy and some training on multi-photon microscopy and XANES/EXAFS
Possess strong understanding of cobalt chaperones used for the delivery of drugs to hypoxic sites such as solid tumours
Dedicated scientist with excellent organisational, troubleshooting and problem-solving skills
Computer-proficient in Microsoft Word, Microsoft Excel, Microsoft PowerPoint, Adobe Photoshop, ChemDraw, and Nikon EZ-C1
Speak, read and write both Japanese and English fluently
Awards
Research grant for doctoral candidates and young academics and scientists, DAAD, 2008
Joan R. Clark Research Scholarship, University of Sdney, 2008
Agnes Campbell Postgraduate Prize, University of Sydney, 2008
Janet Elspeth Crawford Prize in Chemistry, University of Sydney, 2007
Australian Postgraduate Award, University of Sydney, 2007 to Present
University of Sydney Honours Scholarship, University of Sydney, 2006
Walter Burfitt Scholarships No.1 in Chemistry, School of Chemistry, University of Sydney, 2005
Dean’s List of Excellence in Academic Performance, Faculty of Science, University of Sydney, 2004 and 2005
Publications and Conferences
Publications:
Cellular uptake and distribution of cobalt complexes of fluorescent ligands
,
Journal of Biological Inorganic Chemistry,
2008,
13,
861-871
Bioreductive activation and drug chaperoning in cobalt pharmaceuticals
,
Dalton Transactions,
2007,
36,
3983-3990
Studies of a Co(III) complex of the MMP inhibitor marimastat: a potential hypoxia activated prodrug.
,
Chemistry, A European Journal,
2006,
e-published
Conferences:
Oral Presentation, Natsuho Yamamoto
Monitoring the Uptake of Fluorescently Tagged Hypoxia-Selective Cobalt Chaperones
The 4th Asian Biological Inorganic Chemistry Conference; Jeju Island, Korea; November 10th-13th 2008
Poster Presentation, Natsuho Yamamoto, Sarah L. Danos, Elizabeth J. New and Trevor W. Hambley
Using Fluorescent Tagging to Monitor the Cellular Fate of Drugs Delivered by Cobalt Chaperones
Poster presented by Natsuho Yamamoto.
Xth International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy; Verona, Italy; November 30th-December 3rd 2007
Poster Presentation, Natsuho Yamamoto, Sarah L. Danos and Trevor W. Hambley.
Using fluorescent tags to monitor the cellular fate of drugs delivered by cobalt chaperones
Poster presented by Natsuho Yamamoto
XIIIth International Conference on Biological Inorganic Chemistry; Vienna, Austria; July 15th-20th 2007
Poster Presentation, Jenny Z. Zhang, Natsuho Yamamoto, Sarah L. Danos, Rebecca A. Alderden and Trevor W. Hambley
The use of fluorescent tags to study the cellular uptake and metabolism of platinum and cobalt antitumour complexes
Poster jointly presented by Jenny Z. Zhang and Natsuho Yamamoto
Drug Design Amongst the Vines; Hunter valley, NSW, Dec 3rd-7th 2006
Other Interests/Skills
Treasurer, Alchemist Society, University of Sydney, 2008
Secretary, Alchemist Society, University of Sydney, 2007