Protein structure, function and engineering lab Publications from Prof. Jacqui Matthews
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[Publication highlights]

[Joel - all papers] [Jacqui - all papers]

Refereed journal articles

  1. Robertson, N. O., Smith, N. C., Manakas, A., Mahjoub, M., McDonald, G., Kwan, A. H., and Matthews, J. M. (2018)
    Disparate binding kinetics by an intrinsically disordered domain enables temporal regulation of transcriptional complex formation
    Proc Natl Acad Sci U S A 115, 4643-4648


  2. Chong, C. E., Venugopal, P., Stokes, P. H., Lee, Y. K., Brautigan, P. J., Yeung, D. T. O., Babic, M., Engler, G. A., Lane, S. W., Klingler-Hoffmann, M., Matthews, J. M., D'Andrea, R. J., Brown, A. L., Hahn, C. N., and Scott, H. S. (2018)
    Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes
    Leukemia 32, 194-202


  3. Adam, M. K., Jarrett-Wilkins, C., Beards, M., Staykov, E., MacFarlane, L. R., Bell, T. D. M., Matthews, J. M., Manners, I., Faul, C. F. J., Moens, P. D. J., Ben, R. N., and Wilkinson, B. L. (2018)
    1D Self-Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide-Functionalized Perylene Bisimides
    Chemistry 24, 7834-7839


  4. Bhati, M., Llamosas, E., Jacques, D. A., Jeffries, C. M., Dastmalchi, S., Ripin, N., Nicholas, H. R., and Matthews, J. M. (2017)
    Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans
    Sci Rep 7, 4579


  5. Smith, N. C., and Matthews, J. M. (2016)
    Mechanisms of DNA-binding specificity and functional gene regulation by transcription factors
    Curr Opin Struct Biol 38, 68-74


  6. Robertson, N. O., Shah, M., and Matthews, J. M. (2016)
    A Quantitative Fluorescence-Based Assay for Assessing LIM Domain-Peptide Interactions
    Angew Chem Int Ed Engl 55, 13236-13239


  7. McCaughey, L. C., Josts, I., Grinter, R., White, P., Byron, O., Tucker, N. P., Matthews, J. M., Kleanthous, C., Whitchurch, C. B., and Walker, D. (2016)
    Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa
    Biochem J 473, 2345-2358


  8. Wilkinson-White, L., Lester, K. L., Ripin, N., Jacques, D. A., Mitchell Guss, J., and Matthews, J. M. (2015)
    GATA1 directly mediates interactions with closely spaced pseudo-palindromic but not distantly spaced double GATA sites on DNA
    Protein Sci 24, 1649-1659


  9. Wienert, B., Funnell, A., Norton, L., Pearson, R., Wilkinson-White, L., Lester, K., Vadolas, J., Porteus, M., Matthews, J. M., Quinlan, K., and Crossley, M. (2015)
    Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin
    Nat Comm 8, 7058


  10. Kazenwadel, J., Betterman, K., Chong, C.-E., Stokes, P. H., Lee, Y., Secker, G., Agalarov, Y., Demir, C. S., Lawrence, D., Sutton, D., Tabruyn, S., Miura, N., Salminen, M., Petrova, T., Matthews, J. M., Hahn, C., Scott, H., and Harvey, N. (2015)
    GATA2 haploinsufficiency predisposing to lymphedema reveals key roles in lymphatic vascular development
    J Clin Invest 128, 2979-2994


  11. Harten, S., Oey, H., Bourke, L., Bharti, V., Luke, I., Daxinger, L., Faou, P., Robertson, N. O., Matthews, J., and Whitelaw, E. (2015)
    The recently identified modifier of murine metastable epialleles, Re-arranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers
    BMC Biology 13, 21


  12. Fung, H. K., Gadd, M. S., Drury, T. A., Cheung, S., Guss, J. M., Coleman, N. V., and Matthews, J. M. (2015)
    Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes
    Mol Microbiol 97, 439-453


  13. Wilkinson-White, L., and Matthews, J. M. (2014)
    The PA207 peptide inhibitor of LIM-only protein 2 (Lmo2) targets zinc finger domains in a non-specific manner.
    Prot Prot Lett 21, 132-139.


  14. Vandevenne, M., O’Connell, M., Helder, S., Shepherd, N., Matthews, J., Kwan, A., Segal, D., and Mackay, J. (2014)
    Engineering Specificity Changes on a RanBP2 Zinc Finger that binds single-stranded RNA
    Angew Chem, DOI: 10.1002/anie.201402980R201402981


  15. Joseph, J., Kwan, A. H. Y., Stokes, P. H., Mackay, J. P., Cubeddu, L., and Matthews, J. M. (2014)
    The structure of an LIM-only protein 4 (LMO4) and Deformed Epidermal Autoregulatory Factor-1 (DEAF1) complex reveals a common mode of binding to LMO4
    PLOS One 9, e109108


  16. Joseph, J., Kwan, A. H. Y., Mackay, J. P., Cubeddu, L., and Matthews, J. M. (2014)
    Backbone and side-chain assignments of a tethered complex between LMO4 and DEAF-1
    Biol NMR Assign 8, 141-144


  17. Youngson, N., Epp, T., Roberts, A., Daxinger, L., Ashe, A., Huang, E., Lester, K. L., Harten, S., Kay, G., Cox, T., Matthews, J. M., Chong, S., and Whitelaw, E. (2013)
    No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations
    Mamm Genome 24, 206-217


  18. Vandevenne, M., Jacques, D. A., Arzur, C., Nguyen, C. D., Matthews, J. M., Crossley, M., Guss, J. M., and Mackay, J. P. (2013)
    New insights into DNA recognition by zinc fingers revealed by structural analysis of ZNF217
    J Biol Chem 288, 10616-10627


  19. Stokes, P. H., Liew, C. W., Kwan, A. H., Foo, P., Barker, H. E., Djamirze, A., O'Reilly, V., Visvader, J. E., Mackay, J. P., and Matthews, J. M. (2013)
    Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour supor CtIP/RBBP8
    J Mol Biol 425, 1101-1110


  20. Matthews, J. M., and Potts, J. R. (2013)
    The tandem β-zipper: modular binding of tandem domains and linear motifs
    FEBS Lett 587, 1164-1171


  21. Matthews, J. M., Lester, K. L., Joseph, S., and Curtis, D. J. (2013)
    LIM-domain-only proteins in cancer
    Nat Rev Cancer 12, 111-122


  22. Gamsjaeger, R., O'Connell, M. R., Cubeddu, L., Shepherd, N. E., Lowry, J. A., Kwan, A. H., Vandevenne, M., Swanton, M. K., Matthews, J. M., and Mackay, J. P. (2013)
    A structural analysis of DNA binding by Myelin Transcription Factor 1 double zinc fingers
    J Biol Chem 288, 35180-35191


  23. Gamsjaeger, R., Fernando, R., Bang, L. H., Touma, C., Nguyen, C. D., Matthews, J. M., Cubeddu, L., and Mackay, J. P. (2013)
    Semi-quantitative and quantitative analysis of protein-DNA interactions using steady-state measurements in Surface Plasmon Resonance competition experiments
    Analytical Biochemistry 440, 178-185


  24. Gadd, M. S., Jacques, D. A., Nisevic, I., Craig, V. J., Kwan, A. H., Guss, J. M., and Matthews, J. M. (2013)
    A structural basis for the regulation of the LIM-homeodomain protein Islet 1 (Isl1) by intra- and intermolecular interactions
    J Biol Chem 288, 21924-21935


  25. Corciliusa, L., Santhakumar, G., Stone, R. S., Capicciotti, C. J., Joseph, J., Matthews, J. M., Ben, R. N., and Payne, R. J. (2013)
    Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules
    Bioorganic Med Chem 21, 3569-3581


  26. Campbell, A. E., Wilkinson-White, L., Mackay, J. P., Matthews, J. M., and Blobel, G. A. (2013)
    Dissecting molecular pathways that underlie disease-causing GATA1 mutations
    Blood 121, 5218-5227


  27. Yeo, G., Baldock, C., Tuukkanenc, A., Roesslec, M., Dyksterhuis, L., Wise, S., Matthews, J., Mithieux, S., and Weiss, A. (2012)
    The tropoelastin bridge region positions the cell-interactive C-terminus and contributes to elastic fiber assembly
    Proc Natl Acad Sci U S A 109, 2878-2883


  28. Wilkinson, B. L., Stone, R. S., Capicciotti, C. J., Thaysen-Andersen, M., Matthews, J. M., Packer, N. H., Ben, R. N., and Payne, R. J. (2012)
    Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins
    Angew Chem 51, 3606-3610


  29. O'Connell, M. R., Vandevenne, M., Nguyen, C. D., Matthews, J. M., Gamsjaeger, R., Segal, D. J., and Mackay, J. P. (2012)
    Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA
    Angew Chem 51, 5371-5375


  30. Matthews, J. M., and Sunde, M. (2012)
    Dimers, oligomers, everywhere
    Adv Exp Med Biol 747, 1-18


  31. Liew, C. W., Kwan, A. H., Stokes, P. H., Mackay, J. P., and Matthews, J. M. (2012)
    (1)H, (1)(5)N and (1)(3)C assignments of an intramolecular LMO4-LIM1/CtIP complex
    Biomol NMR assign 6, 31-34


  32. Hsieh, Y. S., Wilkinson, B. L., O'Connell, M. R., Mackay, J. P., Matthews, J. M., and Payne, R. J. (2012)
    Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants
    Org Lett 14, 1910-1913


  33. Hauswirth, R., Haase, B., Blatter, M., Brooks, S. A., Burger, D., Drogemuller, C., Gerber, V., Henke, D., Janda, J., Jude, R., Magdesian, K. G., Matthews, J. M., Poncet, P. A., Svansson, V., Tozaki, T., Wilkinson-White, L., Penedo, M. C., Rieder, S., and Leeb, T. (2012)
    Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses
    PloS Genet 8, e1002653


  34. Gadd, M. S., Jacques, D. A., Guss, J. M., and Matthews, J. M. (2012)
    Crystallization and diffraction of an Isl1-Ldb1 complex
    Acta Crystallogr Section F 68, 1398-1401


  35. Dastmalchi, S., Wilkinson-White, L., Kwan, A. H., Gamsjaeger, R., Mackay, J. P., and Matthews, J. M. (2012)
    Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex
    Prot Sci 6, 31-34


  36. Cubeddu, L., Joseph, S., Richard, D. J., and Matthews, J. M. (2012)
    Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4
    PloS One 7, e39218


  37. Bhati, M., Lee, C., Gadd, M. S., Jeffries, C. M., Kwan, A., Whitten, A. E., Trewhella, J., Mackay, J. P., and Matthews, J. M. (2012)
    Solution Structure of the LIM-Homeodomain Transcription Factor Complex Lhx3/Ldb1 and the Effects of a Pituitary Mutation on Key Lhx3 Interactions
    PloS One 7, e40719


  38. Wissmueller, S., Font, J., Liew, C. W., Cram, E., Schroeder, T., Turner, J., Crossley, M., Mackay, J. P., and Matthews, J. M. (2011)
    Protein-protein interactions: analysis of a false positive GST pulldown result.
    Proteins Struct Funct Gen 79, 2365-2371


  39. Wilkinson-White, L., Gamsjaeger, R., Dastmalchi, S., Wienert, B., Stokes, P. H., Crossley, M., Mackay, J. P., and Matthews, J. M. (2011)
    Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
    Proc Natl Acad Sci U S A 108, 14443-14448


  40. Gadd, M. S., Bhati, M., Jeffries, C. M., Langley, D. B., Trewhella, J., Guss, J. M., and Matthews, J. M. (2011)
    The structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification
    J Biol Chem, 42971-42980.


  41. Wilkinson-White, L. E., Dastmalchi, S., Kwan, A. H., Ryan, D. P., Mackay, J. P., and Matthews, J. M. (2010)
    (1)H, (15)N and (13)C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex
    Biomol NMR Assign.


  42. Cross, A. J., Jeffries, C. M., Trewhella, J., and Matthews, J. M. (2010)
    LIM domain binding proteins one and two have different oligomeric states
    J Mol Biol 99, 133-144


  43. Matthews, J. M., Bhati, M., Lehtomaki, E., Mansfield, R. E., Cubeddu, L., and Mackay, J. P. (2009)
    It takes two to tango: the structure and function of LIM, RING, PHD and MYND domains
    Curr Pharm Des 15, 3681-3696


  44. Lowther, J., Robinson, M. W., Donnelly, S. M., Xu, W., Stack, C. M., Matthews, J. M., and Dalton, J. P. (2009)
    The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease
    PLoS Negl Trop Dis 3, e369


  45. Lowry, J. A., Gamsjaeger, R., Thong, S. Y., Hung, W., Kwan, A. H., Broitman-Maduro, G., Matthews, J. M., Maduro, M., and Mackay, J. P. (2009)
    Structural analysis of med-1 reveals unexpected diversity in the mechanism of DNA recognition by gata-type zinc finger domains
    J Biol Chem 284, 5827-5835


  46. Gadd, M. S., Langley, D. B., Guss, J. M., and Matthews, J. M. (2009)
    Crystallization and diffraction of an Lhx4-Isl2 complex
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65, 151-153


  47. Ryan, D. P., Duncan, J. L., Lee, C., Kuchel, P. W., and Matthews, J. M. (2008)
    Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12
    Proteins 70, 1461-1474


  48. Pilotelle-Bunner, A., Matthews, J. M., Cornelius, F., Apell, H. J., Sebban, P., and Clarke, R. J. (2008)
    ATP Binding Equilibria of the Na(+),K(+)-ATPase (dagger)
    Biochemistry 47, 13103-13114


  49. Matthews, J. M., Loughlin, F. E., and Mackay, J. P. (2008)
    Designed metal-binding sites in biomolecular and bioinorganic interactions
    Curr Opin Struct Biol 18, 484-490


  50. Matthews, J. M., Bhati, M., Craig, V. J., Deane, J. E., Jeffries, C., Lee, C., Nancarrow, A. L., Ryan, D. P., and Sunde, M. (2008)
    Competition between LIM-binding domains
    Biochem Soc Trans 36, 1393-1397


  51. Mackay, J. P., Sunde, M., Lowry, J. A., Crossley, M., and Matthews, J. M. (2008)
    Response to Chatr-aryamontri et al.: Protein interactions: to believe or not to believe?
    Trends Biochem Sci


  52. Gamsjaeger, R., Swanton, M. K., Kobus, F. J., Lehtomaki, E., Lowry, J. A., Kwan, A. H., Matthews, J. M., and Mackay, J. P. (2008)
    Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1
    J Biol Chem 283, 5158-5167


  53. Bhati, M., Lee, M., Nancarrow, A. L., Bach, I., Guss, J. M., and Matthews, J. M. (2008)
    Crystallization of an Lhx3-Isl1 complex
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64, 297-299


  54. Bhati, M., Lee, C., Nancarrow, A. L., Lee, M., Craig, V. J., Bach, I., Guss, J. M., Mackay, J. P., and Matthews, J. M. (2008)
    Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
    EMBO J 27, 2018-2029


  55. Stokes, P. H., Thompson, L. S., Marianayagam, N. J., and Matthews, J. M. (2007)
    Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domain
    Biochem Biophys Res Commun 354, 197-202


  56. Porter, C. J., Matthews, J. M., Mackay, J. P., Pursglove, S. E., Schmidberger, J. W., Leedman, P. J., Pero, S. C., Krag, D. N., Wilce, M. C., and Wilce, J. A. (2007)
    Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation
    BMC Struct Biol 7, 58


  57. Mackay, J. P., Sunde, M., Lowry, J. A., Crossley, M., and Matthews, J. M. (2007)
    Protein interactions: is seeing believing?
    Trends Biochem Sci 32, 530-531


  58. Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H. S., de Kretser, D., O'Bryan, M., Blewitt, M., and Whitelaw, E. (2007)
    Modifiers of epigenetic reprogramming show paternal effects in the mouse
    Nat Genet 39, 614-622


  59. Ryan, D. P., Sunde, M., Kwan, A. H.-Y., Marianayagam, N. J., Nancarrow, A. L., vanden Hoven, R. N., Thompson, L. S., Baca, M., Mackay, J. P., Visvader, J. E., and Matthews, J. M. (2006)
    Identification of the key LMO2-binding determinants on Ldb1
    J. Mol. Biol. 359, 66-75


  60. Kwan, A. H., Winefield, R. N., Sunde, M., Matthews, J. M., Haverkamp, R. G., Templeton, M. D., and Mackay, J. P. (2006)
    Structural basis for rodlet assembly in hydrophobins
    Proc. Natl Acad. Sci. USA 103, 3621-3626.


  61. Jeffries, C., Graham, S., Stokes, P. H., Collyer, C. A., Guss, J. M., and Matthews, J. M. (2006)
    Stabilization of a binary protein complex through intein-mediated circularization.
    Protein Science 15, 2612-2618


  62. Ely, L. K., Beddoe, T., Clements, C. S., Matthews, J. M., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J., and Rossjohn, J. (2006)
    Disparate thermodynamics governing TcR-pMHCI interactions implicate extrinsic factors in guiding MHC restriction
    Proc. Natl. Acad. Sci. USA 103, 6641-6646


  63. Begg, G. E., Holman, S. R., Stokes, P. H., Matthews, J. M., Graham, R. M., and Iismaa, S. E. (2006)
    Mutation of a critical GTP-binding arginine in transglutaminase 2 disinhibits crosslinking activity invitro and in vivo
    J. Biol. Chem. 281, 12603-12609


  64. Begg, G. E., Carrington, L., Stokes, P. H., Matthews, J. M., Wouters, M. A., Husain, A., Lorand, L., Iismaa, S. E., and Graham, R. M. (2006)
    Mechanism of allosteric inhibition of transglutaminase 2
    Proc. Natl Acad. Sci. USA 103, 19683-19688


  65. Williams, N., Liepinsh, E., Prosselkov, P., Watt, S. J., Matthews, J. M., Attard, P., Beck, J. L., Dixon, N. E., and Otting, G. (2005)
    Stabilization of Native Protein Fold by Intein-Mediated Covalent Cyclization
    J. Mol. Biol. 346, 1095-1108


  66. Sharpe, B. K., Liew, C. K., Kwan, A. H., Wilce, J. A., Crossley, M., Matthews, J. M., and Mackay, J. P. (2005)
    Assessment of the robustness of a serendipitous zinc-binding fold: mutagenesis and protein grafting
    Structure 13, 257-266


  67. Ryan, D. P., and Matthews, J. M. (2005)
    Protein:Protein Interactions in Human Disease
    Curr Opin Struct Biol 15, 441-446


  68. Liew, C. K., Simpson, R. J. Y., Kwan, A. H., Crofts, L. A., Loughlin, F. E., Matthews, J. M., Crossley, M., and Mackay, J. P. (2005)
    Zinc fingers as protein recognition motifs: structural basis for the GATA-1/Friend of GATA interaction.
    Proc Natl Acad Sci USA 102, 583-588


  69. Lee, C., Nancarrow, A. L., Bach, I., Mackay, J. P., and Matthews, J. M. (2005)
    Letter to the Editor: 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex
    J. Biomol. NMR 33, 198


  70. Duggin, I. G., Matthews, J. M., Wake, G., Dixon, N. E., and Mackay, J. P. (2005)
    A Complex mechanism Controls Polarity of DNA Replication Fork Arrest by the Replication Terminator Complex of Bacillus subtilis
    J. Biol. Chem. 280, 13105-13113


  71. Westman, B. J., Perdomo, J., Matthews, J. M., Crossley, M., and Mackay, J. P. (2004)
    Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers
    Biochemistry 43, 13318-13327


  72. Sunde, M., McGrath, K. C., Young, L., Matthews, J. M., Chua, E. L., Mackay, J. P., and Death, A. K. (2004)
    TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer
    Cancer Res. 64, 2766-2773


  73. Simpson, R. J., Lee, S. H., Bartle, N., Sum, E. Y., Visvader, J. E., Matthews, J. M., Mackay, J. P., and Crossley, M. (2004)
    A classical zinc finger from FOG mediates an interaction with the coiled-coil of TACC3
    J. Biol. Chem. 279, 39789-39797


  74. Marianayagam, N. J., Sunde, M., and Matthews, J. M. (2004)
    The power of two:protein dimerization in biology
    Trends Biochem. Sci. 29, 618-625


  75. Dubin, M. J., Stokes, P. H., Sum, E. Y. H., Williams, R. S., Valova, V. A., Robinson, P. J., Lindeman, G. J., Glover, J. N. M., Visvader, J. E., and Matthews, J. M. (2004)
    Dimerization of a BRCA1- and CtBP-interacting protein is mediated by an N-terminal coiled-coil motif.
    J. Biol. Chem. 279, 26932-26938


  76. Deane, J. E., Ryan, D. P., Sunde, M., Maher, M. J., Guss, J. M., Visvader, J. E., and Matthews, J. M. (2004)
    Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex
    EMBO J. 23, 3589-3598


  77. Turner, J., Nicholas, H., Bishop, D., Matthews, J. M., and Crossley, M. (2003)
    The LIM protein FHL3 is a Basic Krüppel-like Factor (BKLF) co-reor, and forms a three-way nuclear specific complex with BKLF and mCtBP2
    J. Biol. Chem. 278, 12786-12795


  78. Simpson, R., Cram, E., Czjoli, R., Matthews, J. M., Crossley, M., and Mackay, J. P. (2003)
    CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions
    J. Biol. Chem. 278, 28011-28018


  79. Matthews, J. M., and Visvader, J. E. (2003)
    LIM domain binding protein 1 (Ldb1): a multifunctional cofactor that interacts with diverse proteins
    EMBO Reports, 1132-1137


  80. Kwan, A. H., Gell, D. A., Verger, A., Crossley, M., Matthews, J. M., and Mackay, J. P. (2003)
    Engineering a protein scaffold from a PHD finger
    Structure 11, 803-813


  81. Deane, J. E., Maher, M. J., Langley, D., Graham, S., Visvader, J. E., Guss, J. M., and Matthews, J. M. (2003)
    Crystallization of FLINC4, an intra-molecular LMO4:ldb1 complex
    Acta Crystallog D 59, 1484-1486


  82. Deane, J. E., Mackay, J. P., Kwan, A. H., Sum, E. Y., Visvader, J. E., and Matthews, J. M. (2003)
    Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4
    EMBO J 22, 2224-2233


  83. Warton, K., Tonini, R., Fairlie, W. D., Matthews, J. M., Valenzuela, S. M., Qiu, M. R., Wu, W. M., Pankhurst, S., Bauskin, A. R., Harrop, S. J., Campbell, T. J., Curmi, P. M. G., Breit, S. N., and Mazzanti, M. (2002)
    Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in CHO cells exing CLIC1.
    J. Biol. Chem. 277, 26003-26011


  84. Sharpe, B. S., Matthews, J. M., Kwan, A. H.-Y., Newton, A., Gell, D. A., Crossley, M., and Mackay, J. P. (2002)
    A new zinc-binding fold underlines the versatility of zinc-binding modules in evolution
    Structure 10, 639-648


  85. Matthews, J. M., and Sunde, M. (2002)
    Zinc fingers--folds for many occasions
    IUBMB Life 54, 351-355


  86. Kowalski, K., Liew, C. K., Matthews, J. M., Gell, D. A., Crossley, M., and Mackay, J. P. (2002)
    Characterization of the conserved interface between GATA- and FOG-family proteins
    J. Biol. Chem. 277, 35720-35729


  87. Deane, J. E., Visvader, J. E., Mackay, J. P., and Matthews, J. M. (2002)
    1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex
    J. Biomol. NMR 23, 165-166


  88. Matthews, J. M., Visvader, J. E., and Mackay, J. P. (2001)
    1H, 15N and 13C assignments of FLIN2, an intramolecular LMO2:ldb1 complex
    J Biomol NMR 21, 385-386


  89. Mackay, J. P., Matthews, J. M., Winefield, R. D., Mackay, L. G., Haverkamp, R. G., and Templeton, M. D. (2001)
    The hydrophobin eas is largely unstructured in solution and functions by forming amyloid-like structures
    Structure 9, 83-91.


  90. Deane, J. E., Sum, E., Mackay, J. P., Lindeman, G. J., Visvader, J. E., and Matthews, J. M. (2001)
    Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes
    Protein Eng. 14, 493-499.


  91. Matthews*, J. M., Young, T. F., Tucker, S. P., and Mackay, J. P. (2000)
    The core of the respiratory syncytial virus fusion protein is a trimeric coiled coil
    J. Virol. 74, 5911-5920


  92. Matthews, J. M., Norton, R. S., Hammacher, A., and Simpson, R. J. (2000)
    The single mutation Phe173 to Ala induces a molten globule-like state in murine interleukin-6
    Biochemistry 39, 1942-1950


  93. Matthews, J. M., Kowalski, K., Liew, C. K., Sharpe, B. K., Fox, A. H., Crossley, M., and MacKay, J. P. (2000)
    A class of zinc fingers involved in protein-protein interactions biophysical characterization of CCHC fingers from fog and U-shaped
    Eur. J. Biochem. 267, 1030-1038


  94. Matthews, J. M., Hammacher, A., Howlett, G. J., and Simpson, R. J. (1998)
    Physicochemical characterization of an antagonistic human interleukin-6 dimer
    Biochemistry 37, 10671-10680


  95. Simpson, R. J., Hammacher, A., Smith, D. K., Matthews, J. M., and Ward, L. D. (1997)
    Interleukin-6: structure-function relationships
    Protein Sci 6, 929-955


  96. Matthews, J. M., Ward, L. D., Hammacher, A., Norton, R. S., and Simpson, R. J. (1997)
    Roles of histidine 31 and tryptophan 34 in the structure, self-association, and folding of murine interleukin-6
    Biochemistry 36, 6187-6196


  97. #Zhang, J. G., #Matthews, J. M., #Ward, L. D., and Simpson, R. J. (1997)
    Disruption of the disulfide bonds of recombinant murine interleukin-6 induces formation of a partially unfolded state
    Biochemistry 36, 2380-2389 #Equal First Author


  98. Ward, L. D., Hammacher, A., Howlett, G. J., Matthews, J. M., Fabri, L., Moritz, R. L., Nice, E. C., Weinstock, J., and Simpson, R. J. (1996)
    Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex
    J Biol Chem 271, 20138-20144


  99. Ward, L. D., Matthews, J. M., Zhang, J. G., and Simpson, R. J. (1995)
    Equilibrium denaturation of recombinant murine interleukin-6: effect of pH, denaturants, and salt on formation of folding intermediates
    Biochemistry 34, 11652-11659


  100. Matthews, J. M., and Fersht, A. R. (1995)
    Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfolding/folding of barnase
    Biochemistry 34, 6805-6814


  101. Matouschek, A., Matthews, J. M., Johnson, C. M., and Fersht, A. R. (1994)
    Extrapolation to water of kinetic and equilibrium data for the unfolding of barnase in urea solutions
    Protein Eng 7, 1089-1095


  102. Fersht, A. R., Itzhaki, L. S., elMasry, N. F., Matthews, J. M., and Otzen, D. E. (1994)
    Single versus parallel pathways of protein folding and fractional formation of structure in the transition state
    Proc Natl Acad Sci U S A 91, 10426-10429


  103. Schofield, P. J., Edwards, M. R., Matthews, J., and Wilson, J. R. (1992)
    The pathway of arginine catabolism in Giardia intestinalis
    Mol Biochem Parasitol 51, 29-36


  104. Horovitz, A., Matthews, J. M., and Fersht, A. R. (1992)
    Alpha-helix stability in proteins. II. Factors that influence stability at an internal position
    J Mol Biol 227, 560-568
Book chapters

  1. Matthews, J. M. (2013) Zinc finger folds and their functions. in Encyclopedia of Metalloproteins (R. Kretsinger, V. U., E. Permyakov ed., Springer

  2. Matthews, J. M. (2013) LIM Domain Proteins. in Brenner's Encyclopedia of Genetics (Hughes, S. M. a. K. ed., 2nd Ed., Elseveir, Oxford

  3. Matthews, J.M. (2012)
    Defining Protein-Protein Interactions, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer

  4. Matthews, J.M., ed. (2012)
    Protein Dimerization and Oligomerization in Biology. Adv Exp Med Biol. Vol. 747. 2012, Landes Bioscience/Springer.

  5. Matthews, J.M., Bcl-2 Inhibitors, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer.

  6. Matthews, J.M., Mutagenic Scanning to Define Binding Hotspots, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer.

  7. Matthews, J.M., Plasticity at Protein–Protein Interaction Interfaces, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer.

  8. Matthews, J.M., Heteromeric Versus Homomeric Association of Protein Complexes, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer.

  9. Matthews, J.M., LIM Domain Proteins, in Brenner's Encyclopedia of Genetics, S.M.a.K. Hughes, Editor 2013, Elseveir: Oxford. p. 242-245.

  10. Matthews, J.M., Zinc finger folds and their functions, in Encyclopedia of Metalloproteins, V.U. R. Kretsinger, E. Permyakov, Editor 2013, Springer.

  11. Kuchel, P.W., Easterbrook-Smith, S.B., Gysbers, V., Hancock, D.P., Johnston, J.M., Jones, A.R., and Matthews, J.M., Schaum's Outline of Biochemistry. 3rd ed. Schaum's Outline Series 2009: McGraw-Hill.

  12. Matthews, J.M. (2012)
    Postranslational Modifications, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer

  13. Mansfield, R.E., Cross, A.J., Matthews, J.M., and Mackay, J.P. (2009)
    Protein Recognition, in Amino Acids, Peptides and Proteins in Organic Chemistry, A.B. Hughes, Editor 2009, Wiley-VCH: Weinheim.

  14. Matthews, J.M., Ward, L.D., J-G., Z., and Simpson, R.J. (1996)
    The association of unfolding intermediates during the equilibrium unfolding of recombinant murine interleukin-6, in Techniques in Protein Chemistry, D.R. Marshak, Editor 1996, Academic Press, Inc.: San Diego.



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