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Unit of study_
OLET2502: Toxicological Evaluation
2022 unit information
This Open Learning Environment unit of study is designed to introduce you to an underrepresented but essential discipline - Toxicology. This unit will support your development of critical thinking and the scientific approach to problem solving. Concurrent with increasing understanding of the toxicology of materials in society has been an increase in the regulatory importance of toxicology. In this OLE unit you will learn the key elements contributing to toxicological outcomes, including routes of exposure, dose-response, target end-points and vulnerable populations. You will learn how to interpret toxicological data and make predictions about health effects of given levels and types of chemical exposure. This OLE unit will use a problem-based approach with examples of critical analysis of toxicological factual matrices to presage toxicological evaluation and analysis.
Unit details and rules
Managing faculty or University school:
Pharmacy
| Code | OLET2502 |
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| Academic unit | Pharmacy |
| Credit points | 2 |
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Prerequisites:
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None |
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Corequisites:
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None |
| Prohibitions:
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None |
| Assumed knowledge:
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PCOL3011 or OLEO2501 |
At the completion of this unit, you should be able to:
- LO1. • Explain how relative toxicity is used to define the risk associated with chemical exposure. • Identify reliable sources of chemical information. • Recognise routes of exposure in a chemical exposure scenario. • use chemical safety data to identify likely routes of exposure • use chemical safety data to perform a basic exposure assessment • Explain the theory of dose-response curves. • Recognise the effects of dose parameters such as duration and route on toxicological outcomes. • draw a simple dose-response graph • interpret a dose-response graph • define the terms: threshold dose, no-effect dose, lowest effect dose • Given a specific exposure estimate risk using dose-response data
- LO2. • Describe how the characteristics of different age-groups mean they can react differently to toxicants. • Describe some of the metabolic and physiological differences that lead to differences in toxicological responses in people of different sex or individual genetics. • Predict the change to toxicological response resulting from changes in health status
- LO3. • Identify examples of toxicants with organ specific toxicity • Recall reasons for specific organs being differentially affected by toxic chemicals • Explain how xenobiotic metabolism plays an important role in target organ toxicity • Predict the effect of a toxicant based on the physiology and metabolic pathway of its pharmacokinetic disposition
- LO4. • Describe the four steps in a Risk Assessment. • Define “Hazard”. • Find and interpret toxicological sources in order to perform a Hazard Identification task for a given chemical • Explain and interpret Dose-Response data for carcinogenic and non-carcinogenic chemicals. • Find and interpret toxicological sources in order to describe a Dose-Response for a given chemical • Find and interpret Exposure assessment data. • Explain and interpret Exposure assessment data. • Use Dose-Response and Exposure assessment data to synthesise a risk characterisation for a given chemical in a specific scenario. • Analyse and explain the complexity of toxicological risk evaluation and the variety of components which feed into decisions about safety of a particular chemical and a certain context.
Unit availability
This section lists the session, attendance modes and locations the unit is available in. There is a unit outline for each of the unit availabilities, which gives you information about the unit including assessment details and a schedule of weekly activities.
The outline is published 2 weeks before the first day of teaching. You can look at previous outlines for a guide to the details of a unit.
There are no availabilities for this year.
Modes of attendance (MoA)
This refers to the Mode of attendance (MoA) for the unit as it appears when you’re selecting your units in Sydney Student. Find more information about modes of attendance on our website.
