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Unit of study_

SURG5021: Surgical Immunology

Inflammation and immunopathology are encountered frequently in surgical practice, in settings such as acute pancreatitis, inflammatory bowel disease and rejection of organ transplants. Manipulation of the immune system through treatment with checkpoint inhibitors and other forms of immunotherapy is assuming increasing importance in the treatment of malignant melanoma and various other cancers. This unit of study will introduce students to the fundamental aspects of innate and cognate immune responses and their relationship to the clinical manifestations of some common surgical conditions.

Code SURG5021
Academic unit Surgery
Credit points 6

At the completion of this unit, you should be able to:

  • LO1. Describe the components of the innate and adaptive immune systems and how their activities contribute to the pathogenesis of conditions including acute pancreatitis, necrotising fasciitis, ulcerative colitis, ischaemia-reperfusion injury and transplant rejection.
  • LO2. Assess the evidence for the efficacy of various surgical and medical interventions in the management of conditions including acute pancreatitis, necrotising fasciitis, and ulcerative colitis.
  • LO3. Identify the ways in which cancer suppresses the immune system and the types of cancer immunotherapy which specifically target these.
  • LO4. Analyse the evidence supporting the use of cancer immunotherapy for the treatment of solid tumours.
  • LO5. Analyse the relative contributions of innate and adaptive immunity to organ damage following transplantation.
  • LO6. Compare and contrast transplant immunosuppression with the induction of immunological tolerance to transplanted organs.
  • LO7. Discuss the usefulness of biomarkers and other tests in monitoring post-transplant immune responses and individualising treatment.

Unit outlines

Unit outlines will be available 1 week before the first day of teaching for the relevant session.