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Research_

Precision Sleep Medicine (PRISM)

Tackling poor sleep behaviours and sleep disorders

Wellbeing starts from lifestyle: sleep, nutrition, and physical activity. Our multidisciplinary team looks at insomnia, obstructive sleep apnoea, and shift work disorder, and their links to chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer.

Our vision is to develop real-world solutions that positively impact the burden of chronic diseases. We're doing this through building an interdisciplinary research program that spans from bench to bedside. We want to drive advances in prediction, personalisation, prevention, and participation, with the ultimate goal of translating the knowledge into actual solutions.

Sleep disturbance is highly prevalent in our society across the lifespan, imposing a huge burden on the economy and the health system.

How sleep disorders interact with lifestyle factors such as nutrition and physical activity is poorly understood. This node brings together multidisciplinary expertise to address this fundamental gap in knowledge by applying precision medicine approaches.

Key innovations include integration of the positive lifestyle factors of sleep, nutrition, and physical activity to produce a holistic perspective of their role in wellbeing and health. We also work on developing healthcare models that are predictive, personalised, preventative, and participatory. We engage with the general community and health professionals to strengthen health literacy with respect to sleep and general health interactions.

  • Establishment of the Sydney Sleep Biobank, representing a collaboration across 3 local health districts. This includes the establishment of a formal governance structure, attainment of ethics approvals, formal certification as Australia's first sleep biobank, and award of funding from the NSW State Biobank Biospecimen Collection Grant.
  • Establishment of the CardioSleep Research Program, involving a multidisciplinary collaboration within CPC and external partners (RPA and RNS Hospitals), exploring the links between sleep disordered breathing and 3 major cardiovascular diseases, viz. coronary artery disease, atrial fibrillation, and diastolic heart failure.
  • Establishment of the Sleep and Cancer Program, spanning molecular biology, clinical research, and epidemiology, and exploring the influence of intermittent hypoxia and circadian rhythms on cancer biology and clinical outcomes.

Project Node Leader

Professor Peter Cistulli
Read more about Peter Cistulli

Project Node Leader

Associate Professor Kristina Kairaitis
Read more about Kristina Kairaitis