Our group uses cutting-edge microscopy, transgenic and molecular approaches to understand how insulin secretion is regulated in health and disease.
Our lab is at the forefront of modern imaging methods that are revealing some of the defects in insulin secretion.
Our work has a broad interest in what is called stimulus-secretion coupling. This is a process where cells respond to stimulation by secreting. For example, the pancreas, which has specialist cells called beta cells, secretes insulin and changes in the insulin secretion causes diabetes.
Our work deals with the treatment of diabetes, a serious disease which leads to an imbalance in blood sugar levels and is associated with complications such as kidney damage, blindness and cardiovascular disease.
There are two forms of diabetes:
Our research aims to develop new treatments for dealing with diabetes.
Read more on the Thorn Lab website.