University of Sydney Handbooks - 2017 Archive

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Table 1: Pharmacology

Table 1 lists units of study available to students in the Bachelor of Science and combined degrees. The units are available to students enrolled in other degrees in accordance with their degree resolutions.

Unit of study Credit points A: Assumed knowledge P: Prerequisites C: Corequisites N: Prohibition Session

Pharmacology

For a major in Pharmacology, the minimum requirement is 24 credit points from senior units of study listed in this subject area.
Intermediate units of study
PCOL2011
Pharmacology Fundamentals
6    P 6cp from CHEM1XXX and 6cp from (BIOL1XXX, MBLG1XXX)
N PCOL2555 orBMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808
Semester 1
PCOL2012
Pharmacology: Drugs and People
6    A PCOL2011
P 6cp from CHEM1XXX and 6cp from (BIOL1XXX, MBLG1XXX)
N PCOL2555
Semester 2
Senior units of study
PCOL3011
Toxicology
6    P (PCOL2011 and PCOL2012) OR (BMED2401 and 12 additional credit points of BMED240X)
N PCOL3911 or PCOL3001 or PCOL3901
Semester 1
PCOL3911
Toxicology (Advanced)
6    P An average mark of 75 in (PCOL2011 and PCOL2012) or (BMED2401 and 12 additional credit points of BMED240X)
N PCOL3901 or PCOL3011 or PCOL3001
Semester 1
PCOL3012
Drug Design and Development
6    P (PCOL2011 and PCOL2012) OR (BMED2401 and 12 additional credit points of BMED240X)
N PCOL3901 or PCOL3001 or PCOL3912
Semester 1
PCOL3912
Drug Design and Development (Advanced)
6    P An average mark of 75 in (PCOL2011 and PCOL2012) or (BMED2401 and 12 additional credit points of BMED240X)
N PCOL3012 or PCOL3901 or PCOL3001
Semester 1
PCOL3021
Drug Therapy
6    P (PCOL2011 and PCOL2012) OR (BMED2401 and 12 additional credit points of BMED240X)
N PCOL3921 or PCOL3902 or PCOL3002
Semester 2
PCOL3921
Drug Therapy (Advanced)
6    P An average mark of 75 in (PCOL2011 and PCOL2012) or (BMED2401 and 12 additional credit points of BMED240X)
N PCOL3902 or PCOL3002 or PCOL3021
Semester 2
PCOL3022
Neuropharmacology
6    P (PCOL2011 and PCOL2012) OR (BMED2401 and 12 additional credit points of BMED240X)
N PCOL3922
Semester 2
PCOL3922
Neuropharmacology (Advanced)
6    P An average mark of 75 in (PCOL2011 and PCOL2012) or (BMED2401 and 12 additional credit points of BMED240X)
N PCOL3022
Semester 2

Pharmacology

For a major in Pharmacology, the minimum requirement is 24 credit points from senior units of study listed in this subject area.
Intermediate units of study
PCOL2011 Pharmacology Fundamentals

Credit points: 6 Teacher/Coordinator: Dr Brent McParland Session: Semester 1 Classes: 5 workshops (12hr 15 min total), wet and dry labs (1x2 hrs and 4x4 hrs), lectures (2x1 hr per week). Prerequisites: 6cp from CHEM1XXX and 6cp from (BIOL1XXX, MBLG1XXX) Prohibitions: PCOL2555 orBMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808 Assessment: One 2 hour exam (52%), 4 in semester quizzes (8%),reports (36%) and oral presentations (4%). Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study provides the fundamental grounding in four basic areas in Pharmacology: (1) principles of drug action (2) pharmacokinetics and drug metabolism (3) experimental design and autonomic pharmacology, and (4) drug design. The delivery of material involves lectures, practicals, computer-aided learning and problem-based workshops. Practical classes provide students with the opportunity of acquiring technical experience and teamwork skills. Problem-based workshops are based on real-life scenarios of drug use in the community. These workshops require students to integrate information obtained in lectures in order to provide solutions to the problems. Online quizzes accompany each module and are to encourage continued learning throughout the semester.
Textbooks
Rang and Dale's Pharmacology, 8th Edition. H. P. Rang, J. M. Ritter, R. J. Flower, and G. Henderson, (Elsevier 2015 ). Medical Pharmacology at a Glance, 7th edn M.J. Neal: (Blackwell Scientific Publications, 2012).
PCOL2012 Pharmacology: Drugs and People

Credit points: 6 Teacher/Coordinator: Dr Hilary Lloyd Session: Semester 2 Classes: Workshops (6x1.5 hrs), wet and dry labs (1x2 hrs and 4x4 hrs), lectures (2x1 hr per week) Prerequisites: 6cp from CHEM1XXX and 6cp from (BIOL1XXX, MBLG1XXX) Prohibitions: PCOL2555 Assumed knowledge: PCOL2011 Assessment: Lab reports, workshop assignments and quizzes (total 40%) and 2hr exam (60%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study examines four important areas of Pharmacology: (1) Principles of drug action in the nervous system; (2) Drug abuse, addiction and analgesia; (3) Drug treatment of allergies and GI disorders; (4) Introduction to drug discovery and development. The delivery of material involves lectures, practicals, computer-aided learning and problem-based workshops. Practical classes provide students with the opportunity of acquiring technical experience and teamwork skills. Problem-based workshops are based on real-life scenarios of drug use in the community. These workshops require students to apply information obtained in lectures and readings in order to 'solve' the problems. Workshop activities will include oral presentations.
Textbooks
Rang and Dale's Pharmacology, 8th Edition. H. P. Rang, J. M. Ritter, R. J. Flower, and G. Henderson, (Elsevier 2015 ). Medical Pharmacology at a Glance, 7th edn M.J. Neal: (Blackwell Scientific Publications, 2012).
Senior units of study
PCOL3011 Toxicology

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical every 2 weeks. Prerequisites: (PCOL2011 and PCOL2012) OR (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3911 or PCOL3001 or PCOL3901 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the discipline of toxicology. The study of toxicology is central to the assessment of drug safety in drug development and in the explanation of toxicology associated with registered drugs (adverse drug reactions) and drug-drug interactions. These issues as well as the pharmacogenetic basis of adverse reactions will be considered. Environmental toxicology, particularly toxic reactions to environmental agents such as asbestos and pesticides, and target organ toxicology (lung, liver, CNS) are also covered. The diverse world of plants and animal toxins will also be explored. As a final consequence of exposure to many toxicants, the biology and causes of cancer are discussed. As part of the unit students are introduced to basic ideas about the collection and analysis of data from human and animal populations, both in the structured situation of clinical trials, forensic problems and in analysis of retrospective data.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Essentials of Toxicology 2 ed. McGraw Hill. 2010, or, by the same authors: Toxicology: The Basic Science of Poisons. 7 ed. McGraw Hill. 2008.
PCOL3911 Toxicology (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical every second week. Prerequisites: An average mark of 75 in (PCOL2011 and PCOL2012) or (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3901 or PCOL3011 or PCOL3001 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3011. Students will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Essentials of Toxicology 2 ed. McGraw Hill. 2010.. or, by the same authors: Toxicology: The Basic Science of Poisons. 7 ed. McGraw Hill. 2008.
PCOL3012 Drug Design and Development

Credit points: 6 Teacher/Coordinator: Assoc. Professor Margaret Sunde Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: (PCOL2011 and PCOL2012) OR (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3901 or PCOL3001 or PCOL3912 Assessment: One 2 hour exam, class and online quizzes, assignments (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the field of medicinal chemistry associated with drug design and development. The course covers the fundamental aspects of drug discovery and development with reference to the essentials of chemistry and illustrates drug development with examples that include neuraminidase inhibitors and angiotensin converting enzyme inhibitors. The role of computers in drug design is emphasised by classwork and assignments on molecular modelling and structure-activity relationships. The course also extends to a section on the design of diverse pharmacological agents which include compounds for imaging by positron emission tomography (PET), and kinase inhibitors.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
PCOL3912 Drug Design and Development (Advanced)

Credit points: 6 Teacher/Coordinator: Assoc. Professor Margie Sunde Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: An average mark of 75 in (PCOL2011 and PCOL2012) or (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3012 or PCOL3901 or PCOL3001 Assessment: One 2 hour exam, in class and online quizzes, assignments (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3012. Students will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
PCOL3021 Drug Therapy

Credit points: 6 Teacher/Coordinator: Dr Kellie Charles Session: Semester 2 Classes: Two 1 hour lectures per week, three 2 hour tutorials, three 3 hour practicals, elective project (equivalent to four 3 hour practicals) Prerequisites: (PCOL2011 and PCOL2012) OR (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3921 or PCOL3902 or PCOL3002 Assessment: One 2 hour exam, in lecture tests, practical assignment and elective project (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study builds on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of the scientific basis of drug therapy for many of the common diseases of the 21st century. Lecture topics, tutorials and laboratory sessions cover drug treatment of arthritis, cardiovascular disorders, cancer, diabetes and protein misfolding disorders. New approaches to the development of next-generation targeted drugs are also introduced. As part of this course all students will extend the practical skills in understanding scientific literature, statistical analysis, critical problem solving and analytical thinking. Each stuent will conduct a capstone elective project (laboratory or literature-based) in a field relating to current research areas in Pharmacology and supervised by academic members of the department.
Textbooks
Rang & Dale's Pharmacology, 7th edn; Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson (Churchill Livingstone).
PCOL3921 Drug Therapy (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Kellie Charles Session: Semester 2 Classes: Two 1 hour lectures per week, three 2 hour tutorials-advanced material, three 3 hour practicals, elective project (equivalent to four 3 hour practicals, preference given for laboratory-based project). Prerequisites: An average mark of 75 in (PCOL2011 and PCOL2012) or (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3902 or PCOL3002 or PCOL3021 Assessment: One 2 hour exam, two lecture tests, practical assignment and elective project (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the same lecture series as PCOL3021. The tutorials and practical sessions will extend the work provided in PCOL321 to challenge deeper learning in the effect of drug therapy on pathophysiology of chronic diseases.
Textbooks
Rang & Dale's Pharmacology, 7th edn; Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson (Churchill Livingstone).
PCOL3022 Neuropharmacology

Credit points: 6 Teacher/Coordinator: Associate Professor Elena Bagley Session: Semester 2 Classes: Two 1 hour lectures per week, five 1 hour tutorials, three 3 hour practicals, elective project (equivalent to three 4 hour practicals). Prerequisites: (PCOL2011 and PCOL2012) OR (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3922 Assessment: One 2 hour theory exam, tutorial presentation, practical report, lecture quizzes and elective project (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study builds on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of neuropharmacology. The neuropharmacology of the major neurotransmitters and their role in neuropsychiatric diseases is explored together with the treatment of conditions such as Alzheimer's disease, movement disorders, stroke, depression, anxiety, epilepsy, pain and schizophrenia. Elective projects relate to current research areas in Pharmacology.
Textbooks
Nestler, EJ, Hyman, SE and Malenka, RC. Molecular Neuropharmacology: A Foundations for Clinical Neuroscience, 2nd ed. McGraw Hill, 2009.
PCOL3922 Neuropharmacology (Advanced)

Credit points: 6 Teacher/Coordinator: Associate Professor Elena Bagley Session: Semester 2 Classes: Two 1 hour lectures per week, five 1 hour tutorials, three 3 hour practicals, elective project (equivalent to three 4 hour practicals). Prerequisites: An average mark of 75 in (PCOL2011 and PCOL2012) or (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3022 Assessment: One 2 hour theory exam, tutorial presentation, practical report, lecture quizzes and elective project (100%) Campus: Camperdown/Darlington, Sydney Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study builds on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of neuropharmacology. The neuropharmacology of the major neurotransmitters and their role in neuropsychiatric diseases is explored together with the treatment of conditions such as Alzheimer's disease, movement disorders, stroke, depression, anxiety, epilepsy, pain and schizophrenia. Elective projects relate to current research areas in Pharmacology.
Textbooks
Nestler, EJ, Hyman, SE and Malenka, RC. Molecular Neuropharmacology: A Foundations for Clinical Neuroscience, 2nd ed. McGraw Hill, 2009.