This randomised controlled trial examines the effects of vigorous physical activity using an exercise bike versus simple stretching, on plasma levels of endocannabinoids. We also examine, in heavy cannabis users, whether exercise causes the release of tetrahydrocannabinol (THC) from fat stores, raising plasma THC levels, and affecting the desire for cannabis.
Chief Investigator: Associate Professor David Allsop (Lambert Initiative, University of Sydney)
This was a small pilot study to examine whether regular cannabis users exhibited differential sensitivity and tolerance of pain relative to non-cannabis users, using controls on the Cold Pressor Test (CPT). We also examined plasma cannabinoid, endocannabinoid and cortisol levels. The all-male participants gave a negative saliva test for tetrahydrocannabinol (THC) prior to entering the experiment.
This was a collaboration between the Lambert Initiative for Cannabinoid Therapeutics at the University of Sydney, The Langton Centre and South Eastern Sydney Local Health District.
Chief Investigator: Professor Nick Lintzeris (South East Sydney Local Health District)