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Researchers evaluate attempts to improve detection of small babies during pregnancy

24 June 2022

Assessment of the Growth Assessment Protocol (GAP).

Small babies or those that fail to reach their growth potential are at increased risk of poor pregnancy and birth outcomes, including stillbirth. Up to 40 percent of all stillbirths may be related to inadequate growth of the baby during pregnancy. Yet at present only around 1 in 4 of these small babies are identified in pregnancy.

One of the key strategies to reduce the incidence of stillbirth is focused on improving detection of these small babies. Better detection provides the opportunity for improved surveillance and care, thereby reducing poor outcomes.

Research led by Professor Dharmintra Pasupathy, Director of the University of Sydney’s Reproduction and Perinatal Centre with King’s College London has evaluated the clinical utility of the Growth Assessment Protocol (GAP) in improving the detection of small babies during pregnancy.

GAP is a complex antenatal package of care but observations of the effect of it’s introduction in clinical care have resulted in conflicting findings. The team at King’s together with collaborators both nationally and internationally completed the first randomised trial of GAP in the England, during which maternity hospitals were allocated to either standard care or the introduction of the GAP program.

The rate of detection of small babies by ultrasound was measured and compared between hospitals implementing GAP to those which were not.  The study also evaluated the impact of the program on relevant outcomes for the baby and the mother.

The findings have demonstrated that introducing GAP did not improve the proportion of small babies who were identified during pregnancy.  There were also no differences between maternity units using GAP, compared to those continuing their existing care, in terms of things like how women give birth (vaginal birth or caesarean), whether women have complicated births, or whether babies need to stay in the neonatal unit after they were born. Consistent with previous findings, there was significant variation in how GAP was used between participating maternity hospitals.

These findings need to be interpreted in context of standard care practice in the UK and countries of similar settings, which already recommends doctors and midwives arrange additional scans and increased surveillance for women at high risk. As a result, the findings suggest that the GAP does not provide additional benefit to current UK recommendations, which should continue to be considered best practice.

The researchers recommend that future studies on GAP should incorporate a consistent approach to evaluate its introduction in clinical care. 


Declaration: This study was funded by Guy’s and St Thomas’ Charity (MAJ150704), Stillbirth and Neonatal Death Charity - SANDS (RG1011/16) and Tommy’s Charity. Individual academics report various funding and support. Professor Pasupathy was funded by Tommy’s Charity during the period of the study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The published media release and image is provided courtesy of Kings College London.

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Professor Dharmintra Pasupathy
Professor Dharmintra Pasupathy
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