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Molecular Mechanism of Insulin Resistance

Insulin resistance is a major physiological problem that is associated with an inability of insulin to regulate glucose and lipid metabolism. We now know that metabolism is central more...

Supervisor(s): James, David (Professor)

Developing new antibiotics by targeting specific molecular interactions in bacteria

This project focuses on developing a new class of antibiotics by targeting specific molecular interactions in bacteria using a multi-disciplinary fragment-based drug design approach more...

Supervisor(s): Kwan, Ann (Dr)

Brain Cancer and Hypoxia

Aggressive brain tumours, including adult glioblastomas and pediatric DIPGs, are difficult to treat. Survival rates have improved very little over the last 30 years indicating a nee more...

Supervisor(s): Cook, Kristina (Dr)

Dissecting the architecture of the Insulin Signaling Pathway

The aim of this pathway is to understand how the insulin signalling pathway regulates metabolic homeostasis.The Lead Supervisor for this project is David James. This project will a more...

Supervisor(s): James, David (Professor)

Role of Protein Phosphorylation in Cellular Function

Using advances in mass spectrometry-based proteomics this project aims to uncover how phosphorylation affects the function of proteins and cells in both healthy and diseased states. more...

Supervisor(s): James, David (Professor)

Genetics of Healthy Ageing

By exploiting the vast genetic landscape of an outbred mouse population we aim to explore the molecular cause of a range of diseases that limit healthy ageing in humans. This includ more...

Supervisor(s): James, David (Professor)

Using metabolomics and other omics to guide new cancer therapies

This project will investigate cellular status and signaling in novel cancer therapies, especially new irradiation schemes in radiotherapy using metabolomics, transcriptomics and pro more...

Supervisor(s): Kwan, Ann (Dr), McKenzie, David (Professor)

A Novel Role in Stabilizing Vulnerable Atherosclerotic Plaque

Atherosclerosis is the leading cause of cardiovascular deaths, accounting for ~30% of all deaths in Australia in 2018. Atherosclerotic plaque rupture leads to heart failure and stro more...

Supervisor(s): Misra, Ashish (Dr)

Modulating coronary atherosclerosis through perivascular fat (PVAT)

Background: Organ-to-organ communications are vital for living systems and play critical roles in cellular homeostasis. Various studies have demonstrated the existence and significa more...

Supervisor(s): Misra, Ashish (Dr)

Development of Tissue-Targeted Vectors for Musculoskeletal Gene Therapy

A unique opportunity is available for an outstanding PhD scholar to conduct research in developing tissue-targeted AAV vectors for gene delivery and CRISPR gene editing. more...

Supervisor(s): Schindeler, Aaron (Associate Professor)