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A Novel Approach of Inhibiting Pancreatic Cancer Metastasis via Targeting Tumour Micro-Environment Induced Autophagy

Targeting autophagy and metastasis in pancreatic cancer via NDRG1 Pancreatic Cancer (PC) is highly metastatic with the highest mortality of all cancers (~93%). The pancreatic tu more...

Supervisor(s): Sahni, Sumit (Dr)

How invasive cancer cells negotiate the 3D tissue environment

My team uses cell biology approaches to discover the cellular machinery that allows deadly, invasive cancer cells to negotiate the surronding 3D environment. more...

Supervisor(s): O'Neill, Geraldine (Associate Professor)

Mouse models of liver cancer

This project will use mouse models to investigate the role of adiponectin and T-cadherin in models of liver cancer. more...

Supervisor(s): Hebbard, Lionel (Dr), Qiao, Liang (Dr)

Towards a cure for Type I diabetes mellitus

Transfect a lentivirus construct expressing an immunosuppressive peptide in islet cells for the treatment of diabetes type I more...

Supervisor(s): Manolios, Nicholas (Professor), Logan, Grant (Dr)

Interactions between porcine ligands and the human lymphocyte activating receptor NKG2D

Role of NKG2D in the human cellular immune response against porcine xenotransplants. more...

Supervisor(s): Sharland, Alexandra (Dr)

Chemical Biology of Siderophores

Studies of bacterial metal-management strategies have implications for treating iron overload disease and for better understanding bacterial pathogenic virulence. more...

Supervisor(s): Codd, Rachel (Dr)

Understanding how Flaviviruses interact with the host immune system to cause disease

This laboratory is investigating the interaction of neurotropic Flaviviruses with the vertebrate host immune system to discover how it causes immune-mediated disease (immunopatholog more...

Supervisor(s): King, Nicholas (Professor)

Preventing rejection of transplanted organs without using immunosuppressive drugs

The project aims to identify molecular pathways to prevent rejection of transplanted organs in animal models and to apply these findings to clinical transplantation. more...

Supervisor(s): Bishop, Alex (Dr)

An investigation into the mechanisms of immune evasion in metastatic melanoma patients treated with molecular or immune checkpoint inhibitors.

The aim of this project is to characterise the immune reaction and prevalence of immune inhibitory mechanisms present in metastatic melanoma patient tumours whilst on immune checkpo more...

Supervisor(s): Scolyer, Richard (Professor), Long, Georgina (Professor)

An investigation into symbiosis between virulent Rhodococcus equi and protozoa

Can virulent Rhodococcus equi replicate within protozoa found in the soil and gastrointestinal environment of the foal? more...

Supervisor(s): Muscatello, Gary (Dr)