IMMU3202: Semester 2, 2022

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Units IMMU3202 Semester 2 2022 [Normal day]

Unit of study_

IMMU3202: Immunology in Human Disease

Overview

This study unit builds on the series of lectures that outlined the general properties of the immune system, effector lymphocytes and their functions, delivered in the core courses , IMMU2101 - Introductory Immunology and BMED2404 - Microbes, Infection and Immunity (formerly IMMU2001 and BMED2807), IMMU2X11 Immunobiology and MIMI2X02/MEDS2004 Microbes, Infection and Immunity. We emphasise fundamental concepts to provide a scientific basis for studies in clinical immunology; dysfunctions of the immune system e.g. autoimmune disease, immunodeficiencies, and allergy, and immunity in terms of host - pathogen interactions. This unit has a strong focus on significant clinical problems in immunology and the scientific background to these problems. The unit includes lectures from research scientists and clinicians covering areas such as allergy, immunodeficiency, autoimmune disease and transplantation. This course provides challenging information from the forefront of clinical immunology and helps the student develop an understanding of immune responses in human health and disease. This unit directly complements the unit 'Molecular and Cellular Immunology IMMU3102' and students are very strongly advised to undertake these study units concurrently.

Details

Academic unit	Department of Medical Sciences
Unit code	IMMU3202
Unit name	Immunology in Human Disease
Session, year ?	Semester 2, 2022
Attendance mode	Normal day
Location	Camperdown/Darlington, Sydney
Credit points	6

Enrolment rules

Prohibitions ?	IMMU3903
Prerequisites ?	IMMU2101 or BMED2404 or MEDS2004 or MIMI2X02 or IMMU2X11
Corequisites ?	None
Available to study abroad and exchange students	Yes

Teaching staff and contact details

Coordinator	Allison Abendroth, allison.abendroth@sydney.edu.au
Lecturer(s)	Kylie Elizabeth Shaddock , kylie.shaddock@sydney.edu.au
	Carl Feng, carl.feng@sydney.edu.au
	Allison Denise Abendroth, allison.abendroth@sydney.edu.au
	Alexandra Francesca Sharland, alexandra.sharland@sydney.edu.au
	Jamie Triccas, jamie.triccas@sydney.edu.au
	Mainthan Palendira, umaimainthan.palendira@sydney.edu.au
	Jessie Alex Lee, jessie.lee@sydney.edu.au
	Georges Grau, georges.grau@sydney.edu.au
	Helen Marie McGuire, helen.mcguire@sydney.edu.au
	James Jin Sup Yun, james.yun@sydney.edu.au
	Roger Garsia, r.garsia@sydney.edu.au
	Stephen Adelstein, stephen.adelstein@sydney.edu.au

Type	Description	Weight	Due	Length
Final exam (Record+)	Final exam Written exam	50%	Formal exam period	2 hours
Outcomes assessed:
Tutorial quiz	Practical class quizzes Quizzes	5%	Multiple weeks	10 minutes
Outcomes assessed:
Presentation	Workshop Oral Paper presentation Oral presentation	15%	Multiple weeks	12 minutes
Outcomes assessed:
Assignment	Practical assignment Practical assessment	15%	Week 09 Due date: 09 Oct 2022 at 23:59	1250 words
Outcomes assessed:
Presentation	Poster abstract and presentation Poster presentation	15%	Week 12 Due date: 30 Oct 2022 at 23:59	12 min talk and 250 word abstract
Outcomes assessed:
= Type B final exam ?

Detailed information for each assessment can be found on Canvas.

Assessment criteria

The University awards common result grades, set out in the Coursework Policy 2014 (Schedule 1).

As a general guide, a high distinction indicates work of an exceptional standard, a distinction a very high standard, a credit a good standard, and a pass an acceptable standard.

Result name	Mark range	Description
High distinction	85 - 100
Distinction	75 - 84
Credit	65 - 74
Pass	50 - 64
Fail	0 - 49	When you don’t meet the learning outcomes of the unit to a satisfactory standard.

For more information see sydney.edu.au/students/guide-to-grades.

Late submission

In accordance with University policy, these penalties apply when written work is submitted after 11:59pm on the due date:

Deduction of 5% of the maximum mark for each calendar day after the due date.
After ten calendar days late, a mark of zero will be awarded.

Special consideration

If you experience short-term circumstances beyond your control, such as illness, injury or misadventure or if you have essential commitments which impact your preparation or performance in an assessment, you may be eligible for special consideration or special arrangements.

Academic integrity

The Current Student website provides information on academic honesty, academic dishonesty, and the resources available to all students.

The University expects students and staff to act ethically and honestly and will treat all allegations of academic dishonesty or plagiarism seriously.

We use similarity detection software to detect potential instances of plagiarism or other forms of academic dishonesty. If such matches indicate evidence of plagiarism or other forms of dishonesty, your teacher is required to report your work for further investigation.

Weekly schedule

WK	Topic	Learning activity
Week 01	Introduction and course overview; Immunology of pregnancy	Lecture (2 hr)
Week 02	Workshop 1	Workshop (2 hr)
Week 02	Neonatal immunology	Lecture (1 hr)
Week 03	Practical 1. 1. Introduction to the IMMU3202 practical class; 2. Viral case studies: investigating infection, immunity, and diagnosis of varicella zoster virus infections (part 1)	Practical (4 hr)
Week 03	MHC/Genetics of Human Disease; Immunity to infectious pathogens 1: viruses and immune evasion	Lecture (2 hr)
Week 04	Workshop 2	Workshop (2 hr)
Week 04	Immunity to infectious pathogens 2: intracellular and extracellular bacteria	Lecture (1 hr)
Week 05	Practical 2. Viral case studies: investigating infection, immunity, and diagnosis of varicella zoster virus infections (part 2)	Practical (4 hr)
Week 05	Immunity to infectious pathogens 3: parasites; Immunodeficiency-Acquired immunodeficiency-HIV	Lecture (2 hr)
Week 06	Workshop 3. Oral journal paper presentation	Presentation (2 hr)
Week 06	Primary immunodeficiency: Molecular basis of primary immunodeficiences	Lecture (1 hr)
Week 07	Practical 3. Immunodeficiency case studies: acquired and congenital immunodeficiency cases	Practical (4 hr)
Week 07	Skin immunology; Neuroimmunology	Lecture (2 hr)
Week 08	Vaccination and novel vaccines approaches	Lecture (1 hr)
Week 09	Workshop 4. Oral journal paper presentation	Presentation (2 hr)
Week 09	Self-Tolerance and Autoimmunity; Autoimmune Diseases	Lecture (2 hr)
Week 10	Practical 4. Immune-mediated case studies: immune mediated haemolysis and autoimmune disorders	Practical (4 hr)
Week 10	Transplantation Immunology	Lecture (1 hr)
Week 11	Workshop 5	Workshop (2 hr)
Week 11	Tumor Immunology and therapy; Allergic Diseases and immunotherapy	Lecture (2 hr)
Week 12	Advances in Technology-Omics Era in Immunology of Human Disease	Lecture (1 hr)
Week 12	Poster presentation	Presentation (4 hr)
Week 13	Allergy/snake bite and immunotherapies	Practical (4 hr)
Week 13	Aging immune system and immunosenescence; Make up lecture slot/Revision	Lecture (2 hr)

Attendance and class requirements

Attendance: Satisfactory attendance at all workshops and practical classes is therefore a requirement to pass this course. For Immunology in Human Disease, satisfactory attendance is defined as ≥ 80% which means that if you miss more than 2 workshops or 2 practical classes without approved special consideration for illness or misadventure, or pre-approved Special arrangement, you will not be allowed to pass this unit of study. Students who arrive more than 30 minutes late to a tutorial or practical class will be recorded as being absent.

Study commitment

Typically, there is a minimum expectation of 1.5-2 hours of student effort per week per credit point for units of study offered over a full semester. For a 6 credit point unit, this equates to roughly 120-150 hours of student effort in total.

Required readings

All readings for this unit can be accessed through the Library eReserve, available on Canvas.

Cellular & Molecular Immunology, 9th Ed 2018, AK Abbas, AH Lichtman & Pillai, Elsevier.

Learning outcomes

Learning outcomes are what students know, understand and are able to do on completion of a unit of study. They are aligned with the University’s graduate qualities and are assessed as part of the curriculum.

Outcomes
Graduate qualities

At the completion of this unit, you should be able to:

LO1. understand how principles of immunology are applied to the understanding and treatment of human diseases
LO2. demonstrate effective skills in retrieving, analysing, and interpreting scientific information from current literature sources
LO3. demonstrate advanced oral and written communication skills
LO4. demonstrate knowledge of and training in analysis and interpretation of laboratory based experiments

Graduate qualities

The graduate qualities are the qualities and skills that all University of Sydney graduates must demonstrate on successful completion of an award course. As a future Sydney graduate, the set of qualities have been designed to equip you for the contemporary world.

GQ1	Depth of disciplinary expertise Deep disciplinary expertise is the ability to integrate and rigorously apply knowledge, understanding and skills of a recognised discipline defined by scholarly activity, as well as familiarity with evolving practice of the discipline.
GQ2	Critical thinking and problem solving Critical thinking and problem solving are the questioning of ideas, evidence and assumptions in order to propose and evaluate hypotheses or alternative arguments before formulating a conclusion or a solution to an identified problem.
GQ3	Oral and written communication Effective communication, in both oral and written form, is the clear exchange of meaning in a manner that is appropriate to audience and context.
GQ4	Information and digital literacy Information and digital literacy is the ability to locate, interpret, evaluate, manage, adapt, integrate, create and convey information using appropriate resources, tools and strategies.
GQ5	Inventiveness Generating novel ideas and solutions.
GQ6	Cultural competence Cultural Competence is the ability to actively, ethically, respectfully, and successfully engage across and between cultures. In the Australian context, this includes and celebrates Aboriginal and Torres Strait Islander cultures, knowledge systems, and a mature understanding of contemporary issues.
GQ7	Interdisciplinary effectiveness Interdisciplinary effectiveness is the integration and synthesis of multiple viewpoints and practices, working effectively across disciplinary boundaries.
GQ8	Integrated professional, ethical, and personal identity An integrated professional, ethical and personal identity is understanding the interaction between one’s personal and professional selves in an ethical context.
GQ9	Influence Engaging others in a process, idea or vision.

Outcome map

Learning outcomes	Graduate qualities
Learning outcomes

Closing the loop

Poster presentations done on an individual basis rather than in pairs

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Disclaimer

The University reserves the right to amend units of study or no longer offer certain units, including where there are low enrolment numbers.

To help you understand common terms that we use at the University, we offer an online glossary.

Current students

Overview

Details

Enrolment rules

Teaching staff and contact details

Assessment

Assessment criteria

Late submission

Special consideration

Academic integrity

Weekly schedule

Attendance and class requirements

Study commitment

Required readings

Learning outcomes

Graduate qualities

Outcome map

Closing the loop

Disclaimer

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