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Unit of study_

PCOL2922: Clinical Applications of Pharmacology (Adv.)

Semester 2, 2022 [Normal day] - Camperdown/Darlington, Sydney

We all know someone who is being treated with medicines for a major medical condition. So how do drugs work to treat or prevent medical conditions now and in the future? In this unit of study, you will examine these questions relating to six of the main medical challenges affecting the human body and discuss where improvements in treatment are needed. You will explore a range of pharmacotherapeutic options currently available and in development. You will have the opportunity to research and apply your knowledge and understanding to unresolved health-related problems through laboratory- and problem-based tutorials, and explore molecular mechanisms through 3D printing experiments and visualisation tools. By undertaking this unit you will develop your disciplinary expertise in pharmacology and further your skills in critical thinking, problem solving, communication, digital literacy, teamwork and interdisciplinary effectiveness. This unit of study is highly recommended for students interested in pursuing a career in medicine and allied health professions (e.g. nursing, pharmacy, physiotherapy, dentistry) and medical research pathways.

Unit details and rules

Unit code PCOL2922
Academic unit Pharmacy
Credit points 6
Prohibitions
? 
PCOL2012 or PCOL2022 or PCOL2555
Prerequisites
? 
An average mark of 70 or above in [(BIOL1XX7 or MBLG1XX1) or (BIOL1XX3 or BIOL1XX8 or MEDS1X01)] and (CHEM1XX1 or CHEM1903)
Corequisites
? 
None
Assumed knowledge
? 

Fundamentals of pharmacology including pharmacodynamics and pharmacokinetics and molecular pharmacology, for example, as taught in PCOL2011 or PCOL2021 or MEDS2002 or (BMED2401 and BMED2405)

Available to study abroad and exchange students

Yes

Teaching staff

Coordinator Brent McParland, brent.mcparland@sydney.edu.au
Lecturer(s) Tina Hinton, tina.hinton@sydney.edu.au
Jonathon Arnold, jonathon.arnold@sydney.edu.au
Brent McParland, brent.mcparland@sydney.edu.au
Kellie Charles, kellie.charles@sydney.edu.au
Slade Matthews, slade.matthews@sydney.edu.au
Hilary Lloyd, hilary.lloyd@sydney.edu.au
Type Description Weight Due Length
Online task Quiz week 14
Multiple choice questions (MCQs x 15), delivered on-line via Canvas quiz
10% STUVAC
Due date: 11 Nov 2022 at 23:00
20 minutes
Outcomes assessed: LO1 LO7 LO5 LO4 LO2
Presentation Case Study Oral Presentation
PowerPoint in person presentation
5% Week 03
Due date: 16 Aug 2022 at 15:00
5 minutes
Outcomes assessed: LO1 LO8 LO7 LO6 LO5 LO4 LO3 LO2
Assignment Research Article
Writing and research
10% Week 03
Due date: 19 Aug 2022 at 23:00
1 page not including references
Outcomes assessed: LO1 LO2 LO3 LO4 LO5 LO6 LO7 LO8
Online task Quiz week 5
Multiple choice questions (MCQs x 15), delivered on-line via Canvas quiz
10% Week 05
Due date: 02 Sep 2022 at 23:00
20 minutes
Outcomes assessed: LO1 LO7 LO5 LO4 LO2
Assignment group assignment Lab report: Beta-blockers
Lab report
15% Week 06 1850 Words
Outcomes assessed: LO5 LO6 LO7 LO8 LO9 LO10
Online task Quiz week 9
Multiple choice questions (MCQs x 15), delivered on-line via Canvas quiz
10% Week 09
Due date: 07 Oct 2022 at 23:00
20 minutes
Outcomes assessed: LO1 LO7 LO5 LO4 LO2
Presentation group assignment Handover Case 2
Recorded presentation - handover case to another pharmacologist
15% Week 11
Due date: 17 Oct 2022 at 23:00
10 minute
Outcomes assessed: LO1 LO10 LO8 LO7 LO5 LO4 LO3 LO2
Assignment Lab report: Drugs and peristalsis
Lab report
20% Week 11
Due date: 21 Oct 2022 at 23:00
1000 words
Outcomes assessed: LO5 LO6 LO7 LO8 LO9 LO10
Assignment Oral presentation
Recorded presentation: reflection on 3D printing of receptors
5% Week 12
Due date: 28 Oct 2022 at 23:00
3 slide PowerPoint reflection of project
Outcomes assessed: LO1 LO2 LO3 LO4 LO5 LO7 LO8 LO10
group assignment = group assignment ?

Assessment summary

  • Online Quizzes: There are three online quizzes, consisting of 15 MCQs. Quizzes are opened after the completion of each module and are only open for 24 hours.
  • Research Articles and Presentation: All students are required to research, write and submit to Canvas one research article plus present their finding as a five minute oral Powerpoint prresentation for case 1 (workshop 2)
  • Lab reports: Both ‘hands-on’ practical sessions will be written and submitted to Canvas.  The first report will be written as a group and the second as an individual.  Group size is three (min 2 and max 4). The first report will have peer assessment.
  • Handover Presentation: Each group will be required to present case 2 as a video poster presentation (15 minutes) that will serve as a “handover” of the case to another pharmacologist. 
  • Reflective Presentation : All students are required to submit a video presentation on their chosen 3D printed protein (3 sli)

Detailed information for each assessment can be found on Canvas

To successfully complete this Unit of Study you must demonstrate a threshold (pass) standard of attainment of the Unit of Study learning outcomes as measured by performance on the Unit of Study summative assessments. Students who do not reach a threshold standard of proficiency of the Learning Outcomes will receive a maximum mark of 49 FA. Failure to participate in any one or more of the in-semester assessment tasks or the end of semester theory examination may result in a grade of Absent Fail (AF) for the unit.

Assessment criteria

 Result name Mark Range Description
High
distinction
85 - 100 Factual information of a very high standard with a sophisticated grasp of the principles. Clear
evidence of critical analysis and originality of thought.
Distinction 75 - 84 Factual information of a high standard with an excellent grasp of the principles. Some evidence of
critical analysis and originality of thought.
Credit 65 - 74 Factual information is sound. Little or no critical analysis, or originality of thought.
Pass 50 - 64 Factual information is basic and has gaps. Critical analysis and originality of thought is lacking.
Fail 0 - 49 Factual information is irrelevant and/or incorrect. Unsatisfactory standard.

 

For more information see guide to grades.

Late submission

In accordance with University policy, these penalties apply when written work is submitted after 11:59pm on the due date:

  • Deduction of 5% of the maximum mark for each calendar day after the due date.
  • After ten calendar days late, a mark of zero will be awarded.

This unit has an exception to the standard University policy or supplementary information has been provided by the unit coordinator. This information is displayed below:

All assignments must be submitted by the due date and quizzes and exams attended when they are scheduled. Students are expected to manage their time and to prioritise tasks to meet deadlines. Assessment items submitted after the due date without an approved extension using a special consideration or special arrangement form or request will incur penalties. Failure to meet assessment deadlines will incur mark deductions of 5% of the maximum awarded mark available for every day past the due date (for electronic submissions, days late includes Saturdays, Sundays and public holidays). These deductions will continue for 10 calendar days, until the solutions for the assignment are released, or marked assignments are returned to other students. At that point the mark awarded will be zero. For example, on an assignment given a mark of 70/100, the penalty would be 5 marks if submitted up to 24 hours late, resulting in a final mark of 65/100. If the assignment is submitted 6 days late, the penalty would be 30 marks and the final mark would be 40/100. If the assignment is more than 10 days late, submitted after the solutions for the assignment are released, or marked assignments are returned to other students, the final mark will be 0/100. Non-submission of peer assessment will result in a factor of zero being applied to the non-submitted group work mark.

Academic integrity

The Current Student website  provides information on academic integrity and the resources available to all students. The University expects students and staff to act ethically and honestly and will treat all allegations of academic integrity breaches seriously.  

We use similarity detection software to detect potential instances of plagiarism or other forms of academic integrity breach. If such matches indicate evidence of plagiarism or other forms of academic integrity breaches, your teacher is required to report your work for further investigation.

You may only use artificial intelligence and writing assistance tools in assessment tasks if you are permitted to by your unit coordinator, and if you do use them, you must also acknowledge this in your work, either in a footnote or an acknowledgement section.

Studiosity is permitted for postgraduate units unless otherwise indicated by the unit coordinator. The use of this service must be acknowledged in your submission.

Simple extensions

If you encounter a problem submitting your work on time, you may be able to apply for an extension of five calendar days through a simple extension.  The application process will be different depending on the type of assessment and extensions cannot be granted for some assessment types like exams.

Special consideration

If exceptional circumstances mean you can’t complete an assessment, you need consideration for a longer period of time, or if you have essential commitments which impact your performance in an assessment, you may be eligible for special consideration or special arrangements.

Special consideration applications will not be affected by a simple extension application.

Using AI responsibly

Co-created with students, AI in Education includes lots of helpful examples of how students use generative AI tools to support their learning. It explains how generative AI works, the different tools available and how to use them responsibly and productively.

WK Topic Learning activity Learning outcomes
Ongoing Self-directed learning Independent study (65 hr) LO1 LO2 LO3 LO4 LO5 LO6 LO7 LO8 LO9 LO10
Week 01 Overview of CV physiology Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Pathophysiology of angina & myocardial infarction and treatment - 1 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Orientation: meet your group Practical (2 hr) LO9
Workshop 1, Case 1 Workshop (2 hr) LO3 LO5 LO7 LO8 LO9 LO10
Week 02 Pathophysiology of angina & myocardial infarction and treatment - 2 Forum (1 hr) LO1 LO2 LO3 LO4 LO5
Pathophysiology of angina & myocardial infarction and treatment - 3 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Fundamental Cardiovascular Pharmacology Computer laboratory (2 hr) LO5 LO6
Week 03 Introduction to the central nervous system pharmacology Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Recreational drugs 1 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Workshop 2, Case 1 Workshop (2 hr) LO3 LO5 LO7 LO8 LO9 LO10
Week 04 Recreational drugs 2 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Pathophysiology of cocaine induced myocardial infarction Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
ß-blockers Practical (3 hr) LO5 LO6 LO7 LO8 LO9 LO10
Week 05 Overview of immunology and inflammation Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Pathophysiology of asthma and treatment Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Lab review (Beta Blockers) Computer laboratory (2 hr) LO5 LO6 LO7 LO8 LO9 LO10
Workshop 3, Case 2 Workshop (2 hr) LO3 LO5 LO7 LO8 LO9 LO10
Week 06 Pathophysiology of allergy and treatment Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Pathophysiology of IBD & treatment 1 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Week 07 Pathophysiology of IBD & treatment 2 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Gastrointestinal pharmacology Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Working on handover presentation Workshop (2 hr) LO3 LO5 LO7 LO8 LO9 LO10
Week 08 Infection 1 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Infection 2 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Week 09 Drugs and peristalsis Practical (3 hr) LO5 LO6 LO7 LO8 LO9 LO10
Week 10 Antipsychotics & metabolic/endocrine effects Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Pathophysiology of diabetes & treatment Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Lab review (Drugs and peristalsis) Computer laboratory (2 hr) LO5 LO6 LO7 LO8 LO9 LO10
3D printing of receptors project 1 (Pymol) Workshop (2 hr) LO5 LO6 LO9
Week 11 Pathophysiology of lipid disorder & treatment Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Pathophysiology of PCOS Lecture (1 hr) LO3 LO5 LO7 LO8 LO9 LO10
Workshop 5: Group Handover Presentation (Case 2) Workshop (2 hr) LO5 LO6 LO7 LO8 LO9 LO10
Week 12 Treatment of PCOS 1 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Treatment of PCOS 2 Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
3D printing of receptors project 2 Workshop (2 hr) LO3 LO5 LO7 LO8 LO9 LO10
Week 13 Drug interactions and drug safety in pregnancy Lecture (1 hr) LO1 LO2 LO3 LO4 LO5
Review Lecture (1 hr) LO1 LO2 LO3 LO4 LO5

Attendance and class requirements

The University of Sydney Coursework Policy 2014 states:

55 (2) A student enrolled in a unit of study must comply with the requirements set out in the faculty resolutions, award course resolutions or unit of study outline about undertaking the unit of study, including on matters such as: (a) attendance at and participation in lectures, seminars and tutorials; and (b) participation in practical work.

The Faculty of Science resolutions states:

9(1). Students are expected to attend a minimum of 80% of timetabled activities for a unit of study, unless granted exemption by the Associate Dean.

Thus, attendance at a minimum of 80% of all timetabled classes is compulsory for successful completion of the course. Attendance will be recorded. If you do not show sufficient cause for absence from any part of the course you may not be allowed to sit the final examination. Absences from scheduled practical, workshop or tutorial sessions must be supported by appropriate documentation (also see Guidelines for Special Consideration/Arrangements for important information relating to absence from scheduled classes). It may be possible to attend a different practical or tutorial session by special arrangement with the UoS coordinator.

NOTE Students who have selected the remote learning option must attend all scheduled classes remotely and attendance will be recorded at all sessions.

Study commitment

Typically, there is a minimum expectation of 1.5-2 hours of student effort per week per credit point for units of study offered over a full semester. For a 6 credit point unit, this equates to roughly 120-150 hours of student effort in total.

Required readings

All readings for this unit can be accessed through the Library eReserve, available on Canvas.
Ritter J.M. et al., (2020) Rang and Dale’s Pharmacology, 9th edn. (Elsevier)
Neal M.J., (2020) Pharmacology at a Glance, 9th edn (WILEY Blackwell)

Learning outcomes are what students know, understand and are able to do on completion of a unit of study. They are aligned with the University's graduate qualities and are assessed as part of the curriculum.

At the completion of this unit, you should be able to:

  • LO1. describe the physiological and pathophysiological processes involved in a range of significant diseases and disorders in society
  • LO2. explain the mechanisms of action, effectiveness and safety of many classes of medicinal drugs used to treat: cardiovascular, respiratory, infection, gastrointestinal diseases, and endocrine disorders (diabetes and polycystic ovary syndrome (PCOS))
  • LO3. explore the ethical questions and unresolved issues in pharmacotherapeutic approaches to a range of significant diseases and disorders
  • LO4. evaluate the strength of evidence for claims around pharmacotherapies for a range of significant diseases and disorders
  • LO5. integrate pharmacological knowledge with knowledge in other disciplinary areas of biomedical sciences
  • LO6. describe the essential components of experimental design and be able to analyse, interpret and critique data arising from laboratory experiments
  • LO7. use a variety of sources of information and technologies for research purposes and critically evaluate the information for reliability and relevance
  • LO8. communicate effectively via written articles, informal discussion and oral presentations
  • LO9. work collaboratively and effectively with peers in group learning activities and assessments
  • LO10. demonstrate capacity for reflection on matters related to learning, personal and social responsibility, professional integrity and the value of pharmacology in society

Graduate qualities

The graduate qualities are the qualities and skills that all University of Sydney graduates must demonstrate on successful completion of an award course. As a future Sydney graduate, the set of qualities have been designed to equip you for the contemporary world.

GQ1 Depth of disciplinary expertise

Deep disciplinary expertise is the ability to integrate and rigorously apply knowledge, understanding and skills of a recognised discipline defined by scholarly activity, as well as familiarity with evolving practice of the discipline.

GQ2 Critical thinking and problem solving

Critical thinking and problem solving are the questioning of ideas, evidence and assumptions in order to propose and evaluate hypotheses or alternative arguments before formulating a conclusion or a solution to an identified problem.

GQ3 Oral and written communication

Effective communication, in both oral and written form, is the clear exchange of meaning in a manner that is appropriate to audience and context.

GQ4 Information and digital literacy

Information and digital literacy is the ability to locate, interpret, evaluate, manage, adapt, integrate, create and convey information using appropriate resources, tools and strategies.

GQ5 Inventiveness

Generating novel ideas and solutions.

GQ6 Cultural competence

Cultural Competence is the ability to actively, ethically, respectfully, and successfully engage across and between cultures. In the Australian context, this includes and celebrates Aboriginal and Torres Strait Islander cultures, knowledge systems, and a mature understanding of contemporary issues.

GQ7 Interdisciplinary effectiveness

Interdisciplinary effectiveness is the integration and synthesis of multiple viewpoints and practices, working effectively across disciplinary boundaries.

GQ8 Integrated professional, ethical, and personal identity

An integrated professional, ethical and personal identity is understanding the interaction between one’s personal and professional selves in an ethical context.

GQ9 Influence

Engaging others in a process, idea or vision.

Outcome map

Learning outcomes Graduate qualities
GQ1 GQ2 GQ3 GQ4 GQ5 GQ6 GQ7 GQ8 GQ9

This section outlines changes made to this unit following staff and student reviews.

Remove final exam and increase weighting of quizzes.

Additional costs

There are no additional costs for this unit.

Site visit guidelines

There are no site visit guidelines for this unit.

Work, health and safety

Work, health and safety requirements  

We are governed by the Work Health and Safety Act 2011, Work Health and Safety Regulation 2011 and Codes of Practice. Penalties for non-compliance have increased. Everyone has a responsibility for health and safety at work. The University’s Work Health and Safety policy explains the responsibilities and expectations of workers and others, and the procedures for managing WHS risks associated with University activities.

General Laboratory Safety Rules

  • No eating or drinking is allowed in any laboratory under any circumstances 
  • A laboratory coat and closed-toe shoes are mandatory 
  • Follow safety instructions in your manual and posted in laboratories 
  • In case of fire, follow instructions posted outside the laboratory door 
  • First aid kits, eye wash and fire extinguishers are located in or immediately outside each laboratory 
  • As a precautionary measure, it is recommended that you have a current tetanus immunisation. This can be obtained from University Health Service: unihealth.usyd.edu.au/

Disclaimer

The University reserves the right to amend units of study or no longer offer certain units, including where there are low enrolment numbers.

To help you understand common terms that we use at the University, we offer an online glossary.