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The NeuroMusic Collaborative

World-first study to find out if musical training can slow the rate of cognitive decline to avoid dementia

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Dementia affects around 50 million people globally, a number that is tipped to triple in the next 30 years. 

With no cure yet, we're working on a groundbreaking research program to see if we can slow the rate of cognitive decline with music, to prevent dementia.

Waves will be running intermittently throughout the next 2 years. Once you check your eligibility, we will contact you to let you know the next start date

Find out more
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We're looking for NSW-based adults aged between 60-90 years to join our trial. Previous musical experience not needed.

How you can help

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Check your eligibility

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To participate in our trial

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Contact Us

Zoe Menczel Schrire - Trial Co-ordinator

Phone: +61 2 9351 0755

Email: neuromusic.info@sydney.edu.au

Overview

Enabled by a generous philanthropic gift from Barbara Spencer, this three-year program will test whether music training workshops are a feasible cognitive training intervention for people experiencing mild cognitive decline - the stage before dementia develops.

Through an intensive music training course, imaging studies, and neurological and psychological testing, the program will provide evidence for what happens next in this space: a new field of research, broader studies, and music training programs for cognitive intervention within community settings.

Our hypothesis

Neuroplasticity is the brain's ability to reorganise itself by forming new neural connections throughout life. It allows the neurons in the brain to compensate for and respond to new situations or to changes in their environment - like illness or injury.

Lead investigator, Professor Sharon Naismith, says neuroplasticity is supported by cognitive training. Activities that require effort, repetition, and adjustment (learning from mistakes) stretch us, which helps protect our neuroplasticity.

"Training, acquiring and mastering new skills and knowledge is 'cognitive reserve', which is listed as one of the 12 known lifestyle factors affecting a person's risk of developing dementia.

"Musicians know this type of training intimately. In neuroscience, we have results from other studies tracking cognitive training, but there is still very little scientific evidence to show how it could be used to help people who may be at risk of developing dementia.

"This is an exciting opportunity to lay down that evidence and take that extra step towards reducing cognitive decline."

Eligibility

We are seeking adults aged between 60-90 years with memory difficulties and no previous experience in instrumental playing or singing in an organised group in the last 6 months.

  • have a history of employment as a professional musician;
  • have played an instrument or sang in an organised group in the last 6 months
  • have had more than 3 years of formal music lessons
  • have problems affecting hand dexterity;
  • have impaired or not-corrected visual or auditory accuracy;
  • have other major neurological problems (e.g. stroke, epilepsy, head injury);
  • have an alcohol or substance use disorder;
  • have a severe mental health disorder (e.g. schizophrenia, bipolar disorder);
  • have a current diagnosis of major depression;
  • have commenced with antidepressants or engaged in a music training program or cognitive training intervention within the prior 4 weeks.

What does the study involve?

  • Participants will join either a choir, piano or film group for 3 months and will be asked to complete cognitive tests and questionnaires at 3 and 9 months, and a blood test at 9 months.
  • Choir Participants will learn to sing together and to harmonise with the voices of others.
  • Piano Participants will learn how to navigate the keyboard and discover the sounds and feeling of the piano when performing together.
  • Film Participants will watch and discuss films together with soundtracks reflecting a broad range of musical genres.
  • All participants will experience a vibrant and energising group musical environment where they will explore an exciting mix of genres, including popular, classical, and folk music. 

Study design

During the program's first phase, researchers from the Brain and Mind Centre and the Sydney Conservatorium of Music will work with small focus groups of participants enrolled in the Healthy Brain Ageing Clinic. The focus groups provide the framework for the design of the music training workshops that will be offered as part of the study.

Researchers will then offer music training to older adults with concerns about cognitive decline and who have been assessed by the Healthy Brain Ageing Clinic. At this stage, workshops are not open to wider participation as this marks the feasibility study, which measures the impact of music training on a small group of participants.

Participants of the feasibility study volunteer to be assessed at three points over the course of training:

  • Magnetic resonance imaging (MRI) will capture any changes in brain structure, such as loss of mass in key areas associated with Alzheimer's disease.
  • Psychometric assessments will test learning, memory consolidation, speed of processing and other cognitive factors.
  • Surveys and interviews will also measure the psychosocial characteristics, such as self-reported mental health and well-being factors.

To account for the known health benefits of social engagement, which may also contribute to any observed changes, a second group of participants may join in a social music series that fosters similar social interactions.

We hope that in three years we will have the evidence that sets the stage for music training programs that could be provided in community settings or public health services.

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More information

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Download participant information statement (pdf, 509KB)

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Make a difference

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Donate to support our research

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Meet the team

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