Drug-resistant XDR typhoid on our doorstep

18 September 2019
Improvements needed in travel health planning
MBI researchers report Australia's first case of extensively drug-resistant (XDR) typhoid

Members of MBI reported in the Medical Journal of Australia the first case of XDR typhoid identified in Australia. A 20‐month‐old Australian‐born girl presented to the Children's Hospital at Westmead with features of enteric fever 14 days after her return from a 3‐month trip to Karachi. Diarrhoea began in Pakistan 6 weeks before her return, and continued despite the use of oral antibiotics prescribed locally in Pakistan. Ten days of high fevers, irritability, vomiting and reduced oral intake prompted admission to our hospital. She was a previously well child and had received routine vaccines. No additional pre‐travel vaccinations had been recommended. The child responded to intravenous meropenem and oral azithromycin and was discharged a week after admission.