However, inclusion of an ortho‐substituted benzene ring in the centre of the alkyl spacer resulted in decreased cytotoxicity and hemolytic activity, while maintaining antifungal potency. Replacement of the alkyl and aromatic‐containing spacers by more hydrophilic ethylene glycol groups resulted in a loss of antifungal activity. Some of the compounds inhibited fungal PLB1 activity, but the low correlation of this inhibition with antifungal potency indicates PLB1 inhibition is unlikely to be the predominant mode of antifungal action of this class of compounds, with preliminary studies suggesting they may act via disruption of fungal mitochondrial function.
This methodology has enjoyed increasing popularity among researchers internationally and has been inspired by developments across a range of disciplines: ethnography, visual and applied anthropology, medical sociology, health services research, medical and nursing education, adult education, community development, and qualitative research ethics.
Co-hosted by Centre for Infectious Diseases and Microbiology - Public Health (CIDM-PH), Marie Bashir Institute for Infectious Diseases and Biosecurity (MBI) and Centre for Infectious Diseases and Microbioloby Laboratory Services - NSW Health Pathology (CIDMLS), this symposium is aimed at researchers, clinicians and students looking to learn more about the innovations and challenges in infection control.