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This project aims to develop a simplified workflow for reprocessing paraffin-embedded tissues to enable multimodal microscopic analysis, integrating x-ray, light, and electron microscopy to collect complementary structural information.
Associate Professor Filip Braet.
Camperdown - School of Medical Sciences
This project involves developing a sample preparation and bioimaging workflow for reprocessing paraffin-embedded tissues for multimodal microscopic analysis across length scales. Paraffin embedded tissue retains a wealth of structural information not fully exploited via light-microscopy alone. We aim to develop a simplified workflow that allows the collection of complementary structural information utilising, x-ray, light- and electron microscopy. Successful implementation of this novel approach will be applied to the investigation of relevant experimental animal models and clinical samples. The development of this innovative “morphomics” workflow will allow us to bolster our nano-analytical toolbelt to better understand pathobiological alterations and processes in human disease and as such give a new direction to “-omics science”.
Research location: Sydney Microscopy & Microanalysis (Madsen Building F09)
The opportunity ID for this research opportunity is 3471