Research Supervisor Connect
This project studies giant mitochondria in human liver tissue to elucidate the ultrastructural mechanisms behind their formation, given their significance in cellular function, health, and aging. Using transmission electron microscopy, the research will investigate mitochondrial structural alterations in response to alcohol and other exogenous agents.
Associate Professor Filip Braet.
Camperdown - School of Medical Sciences
Mitochondria are the primary cellular structures that generate energy required to power the cells’ biochemical reactions. Giant mitochondria are abnormal, extremely large mitochondria, observed in a variety of pathologies which are characterised by atypically arranged cristae, enlarged matrix granules and paracrystalline inclusions from unknown origin. Understanding the mechanism of mitochondrial gigantism and associated mitochondriopathies is essential given the importance of mitochondria to cellular function, human health and aging. This project involves the study of giant mitochondria in human liver tissue biopts to elucidate the ultrastructural mechanisms underlying their formation. Transmission electron microscopy will be applied to assess mitochondrial structural alterations in response to alcohol and other exogenous agents.
Research location: Sydney Microscopy & Microanalysis (Madsen Building F09)
The opportunity ID for this research opportunity is 3472