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Computational Modeling of Immune Cell Chemotaxis and Swarming

 Using computational simulation to form and evaluate hypotheses concerning the factors that drive immune cell motility, such as neutrophil swarming, during inflammation. more...

Supervisor(s): Read, Mark (Dr)

Fluorescent sensing of labile metal pools

Metals play an important role in biology, but there are only limited tools to study their functions and interactions. In this project we will develop new fluorescent tools to study more...

Supervisor(s): New, Elizabeth (Associate Professor)

Influencing anti-inflammatory functions of monocytes by targeting the haemoglobin scavenger receptor CD163: possible role in the development of diabetes complications

This project addresses the problem of how causes of diabetes complications, specifically the effect of diabetes on the regulation of one of these anti-inflammatory cell surface prot more...

Supervisor(s): Min, Danqing (Dr), McLennan, Susan (Dr), Twigg, Stephen (Professor)

Telomere deprotection and cancer

Genome stability in human cells is maintained through the coordinated functions of the DNA damage response. We study these processes with particular interest in the pathways that re more...

Supervisor(s): Cesare, Tony (Dr)

Feature-Centric Content Analysis for Bioimaging Informatics

This study aims to develop novel algorithms for content analysis in microscopic images, such as segmentation of cell nuclei, detection of certain cell structures, and tracing of cel more...

Supervisor(s): Cai, Tom Weidong (Associate Professor)

Beyond Neuroinflammation: The Role of Microglia in Synaptic Plasticity

Microglia are the immune cells of the brain and are known to respond to infectious and non-infectious insults to the nervous system. Recently, a new function has been demonstrated f more...

Supervisor(s): Graeber, Manuel (Professor)

Prevention of cardiac side effects of cancer treatment

This project will investigate a novel drug combination therapy that has potential benefits in cancer treatment induced heart failure by targeting Na+-K+ pump function. more...

Supervisor(s): Liu, Chia-chi (Dr), Ramussen, Helge (Professor)

Pharmacological targeting of the metastasis suppressor NDRG1 using novel therapeutics

Metastasis is the major killer in cancer, being extremely difficult to treat. This project will elucidate the molecular mechanisms that initiate and sustain metastatic progression, more...

Supervisor(s): Kovacevic, Zaklina (Dr), Richardson, Des (Professor)

PET imaging of glioma in a TSPO knockout model

Glioblastoma is the most frequent primary brain tumour and the most malignant glial neoplasm (glioma) with predominantly astrocytic differentiation. Due to their invasive nature, gl more...

Supervisor(s): Graeber, Manuel (Professor), Banati, Richard (Professor)

The HAMLET molecular species with anticancer properties

We are interested to determine how the anti-cancer properties of this family of molecules can be translated into cancer treatment. We believe there may be a delivery system which n more...

Supervisor(s): Church, W Bret (Dr)