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Utility of Cerebrospinal fluid proteomics to define molecular mechanisms in brain disease of childhood.

Brain diseases of childhood are very common and result in significant disability, and cost to the nation. Common diseases include epilepsy, cerebral palsy, autism and mental health more...

Supervisor(s): Dale, Russell (Professor)

Analysis of Human Responses to Intermittent Fasting

Analysis of human samples generated from intervention-based clinical trials of intermittent fasting. Our aim is to understand the molecular mechanisms mediating the beneficial pheno more...

Supervisor(s): Larance, Mark (Dr)

Characterising changes in a proteome of islets and islet cell types during progression to type 2 diabetes

Characterizing changes in a proteome through pathogenesis of diseases can provide unparalleled insights into the mechanisms underpinning disease. In this project, using flow cytomet more...

Supervisor(s): Kebede, Melkam (Dr)

Effect of maternal high glycemic index diets on offspring metabolic phenotype

We are uncovering fascinating effects of different sugars (glucose, fructose, sucrose and isomaltulose) on development of embryos and offspring.  High glucose fed mice are sign more...

Supervisor(s): Bell-Anderson, Kim (Dr)

Characterising insulin secretory granules as a function of age

In β-cells, insulin is stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that SGs exist in two functionally distin more...

Supervisor(s): Kebede, Melkam (Dr)

Inferring the dimensionality of dynamical systems automatically using machine learning

This research will develop methods to infer the dimensionality of a dynamical system automatically, by adapting dimensionality reduction methods to high-dimensional time-series feat more...

Supervisor(s): Fulcher, Ben (Dr)

Brain reading

This project seeks to elucidate the connection between brain and behaviour. To this end, students will use human neuroimaging experiments (fMRI, MEG, EEG) to measure how the brain r more...

Supervisor(s): Carlson, Thomas (Associate Professor)

Design and synthesis of selective anion receptors to facilitate transmembrane anion transport in epithelial cells

CF is a recessive genetic condition that results from the dysregulation of anion transport through the cystic fibrosis transmembrane regulator anion channel in epithelial cell membr more...

Supervisor(s): Gale, Philip (Professor)

A New Therapeutic Strategy to Overcome Multidrug Resistance by Exploiting Drug-Transporters to Target Untreatable Cancers

We recently have discovered a frontier strategy for overcoming drug resistance mediated by P-glycoprotein (Pgp) in the lysosome. Identifying new targets for resistant cancers are cr more...

Supervisor(s): Jansson, Patric (Dr)

CRF-dopamine interactions in chronic stress

The project will focus on the interactions between CRF and the dopaminergic nuclei of the ventral midbrain and their role in modulating behaviour selection. more...

Supervisor(s): Mor, David (Dr)