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Regulation of stem cell behaviour using functional biomolecules

Investigate and develop new ways of manipulating different aspects of stem cell behaviour.  This knowledge paves the way towards understanding their fundamental biology and cre more...

Supervisor(s): Yeo, Giselle (Dr)

Characterising changes in a proteome of islets and islet cell types during progression to type 2 diabetes

Characterizing changes in a proteome through pathogenesis of diseases can provide unparalleled insights into the mechanisms underpinning disease. In this project, using flow cytomet more...

Supervisor(s): Kebede, Melkam (Dr)

Computational characterisation of trans-regulatory cell systems

This project aims provide enabling computational and statistical methods for characterising trans-regulatory networks in cell systems. The goal is to discover regulatory networks th more...

Supervisor(s): Yang, Pengyi (Dr)

Viral Commandeering of Cellular Oncogenic Signalling Pathways

Cell-to-cell spread of caccinia virus infection induces dramatic rearrangements to cell morphology and alterations to cell behaviour.  This project will study the role of host more...

Supervisor(s): Newsome, Timothy (Dr)

Characterising insulin secretory granules as a function of age

In β-cells, insulin is stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that SGs exist in two functionally distin more...

Supervisor(s): Kebede, Melkam (Dr)

Sorting proinsulin into secretory vesicles

Reduction in glucose-stimulated mature insulin secretion and increased constitutive and regulated secretion of proinsulin are characteristics of β-cell failure. This may be due more...

Supervisor(s): Kebede, Melkam (Dr)

Design and synthesis of selective anion receptors to facilitate transmembrane anion transport in epithelial cells

CF is a recessive genetic condition that results from the dysregulation of anion transport through the cystic fibrosis transmembrane regulator anion channel in epithelial cell membr more...

Supervisor(s): Gale, Philip (Professor)

Computational approaches to elucidate Multiple Sclerosis and Contact Dermatitis pathogenesis, and its treatment through ultraviolet light exposure

Allergies and autoimmunity are complex immune system aberrations. Both involve multiple immune cell populations coordinating across several organs of the body. The growing prevalenc more...

Supervisor(s): Read, Mark (Dr)

Evolution of viviparity in fish

My lab offers a range of opportunities to build on our research program examining the evolution of reproductive complexity in fish, especially seahorses and sharks. Please see our w more...

Supervisor(s): Whittington, Camilla (Dr), Murphy, Christopher R (Professor)

A New Therapeutic Strategy to Overcome Multidrug Resistance by Exploiting Drug-Transporters to Target Untreatable Cancers

We recently have discovered a frontier strategy for overcoming drug resistance mediated by P-glycoprotein (Pgp) in the lysosome. Identifying new targets for resistant cancers are cr more...

Supervisor(s): Jansson, Patric (Dr)