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The global analysis of liver protein complexes during the response to intermittent fasting

In animals, short periods of nutrient deprivation, such as intermittent fasting, have been shown to provide benefits with regard to cancer risk/treatment and ageing. Our aims are to more...

Supervisor(s): Larance, Mark (Dr)

How to stop an epileptic seizure - looking for the right molecules to target

Over 400 proteins are implicated in epilepsy. This project involves interrogating models of epilepsy to determine which are the key pathways and molecular mechanisms which could be more...

Supervisor(s): Graham, Mark (Dr)

How do molecules make memories? Understanding synaptic plasticity at the level of protein pathways and signalling.

This project aims to discover and validate new molecular mechanisms of how synaptic plasticity, which underlies learning and memory, is regulated by protein interactions and phospho more...

Supervisor(s): Graham, Mark (Dr)

PET imaging of glioma in a TSPO knockout model

Glioblastoma is the most frequent primary brain tumour and the most malignant glial neoplasm (glioma) with predominantly astrocytic differentiation. Due to their invasive nature, gl more...

Supervisor(s): Graeber, Manuel (Professor), Banati, Richard (Professor)

Pharmacological targeting of sphingosine 1-phosphate receptors to promote remyelination in Alzheimer’s disease and multiple sclerosis

In this project you will investigate a new molecular pathway that is required for normal myelin formation, and the therapeutic potential of targeting this pathway to promote remyeli more...

Supervisor(s): Don, Anthony (Associate Professor)

Machine learning of -omic data for discovery of disease processes.

This project builds on a number of recent findings and aims to bring together omics data related to disease and machine learning for the prediction of transcriptional regulators inv more...

Supervisor(s): Waardenberg, Ashley (Dr), Arthur , Jonathan (Associate Professor)

Computational characterisation of trans-regulatory cell systems

This project aims provide enabling computational and statistical methods for characterising trans-regulatory networks in cell systems. The goal is to discover regulatory networks th more...

Supervisor(s): Yang, Pengyi (Dr)

Discovery and validation of new ceramide synthase inhibitors to treat metabolic disease

Ceramide synthase enzyme isoforms 1, 5, and 6, are heavily implicated as drivers of obesity, insulin resistance, and diabetes. Targeting these enzymes is expected to yield new thera more...

Supervisor(s): Don, Anthony (Associate Professor), Qi, Jacob (Dr)

Development of novel anti-cancer metastasis agents derived from omega-3 fatty acid metabolites

At present we have no therapies that prevent cancer spread. In this project we will develop novel w-3 fatty acid epoxide analogues that inhibit tumour metastasis. These derivatives more...

Supervisor(s): Murray, Michael (Professor)

Targeting melanoma secretory pathways.

Cancer cells secrete a variety of factors that induce tumour growth, metastasis, angiogenesis, and alter the tumour stroma to create a more favourable microenviroment. This project more...

Supervisor(s): Weninger , Wolfgang (Professor), Beaumont, Kimberley (Dr)