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CHARACTERISATION OF ERUSIOLIN - A NEW PEPTIDE HORMONE

In this project we aim to characterise the function of a new gut-derived peptide we have discovered in human plasma, named erusiolin, which we hypothesise plays a role in appetite r more...

Supervisor(s): Larance, Mark (Dr)

Define regulatory control pathways delivering NPF (nitrate) and AMT (ammonium) transport activities across root types and cell profiles

We have previously identified the tissue expression patterns of ZmNPF6;6 and ZmNPF6;4 in maize root tips (Wen, Z., et al., The Plant Cell, 2017) and used qPCR as well as custom arra more...

Supervisor(s): Kaiser, Brent (Professor)

Chemical synthesis and phenotypic validation of precision proteolysis targeted chimeras (PROTACs) for cancer and cardiovascular disease

Emerging from the interface between chemistry and biology, chemical biology has led to the establishment of several game-changing drug discovery paradigms. Among these revolutionary more...

Supervisor(s): Liu, Xuyu (Dr), Payne, Richard (Professor)

Molecular insights into a novel mammalian oxygen-sensing pathway

Oxygen (O2) is a vital biological resource most prominently known for its role as the final electron acceptor in aerobic respiration and, as such, adequate molecular mechanisms are more...

Supervisor(s): White, Mark (Dr), Mackay, Joel (Professor)

Investigating how we can utilize the endogenous opioid system to manage pain

The burden of chronic pain is a major cause of human suffering that is now estimated to cost Australia more than $73B per annum and even the most effective th¬¬erapeutics do more...

Supervisor(s): Bagley, Elena (Associate Professor)

Defining the genetic link between nitrate and ammonium transport proteins and root architecture in Maize and Barley

We have previously tested two contrasting maize inbred lines on their inherent nitrate transport rates and respective responses to growth at low nitrogen supply. The lines were sele more...

Supervisor(s): Kaiser, Brent (Professor)

STUDIES OF VARIABLE OR CONSERVED SURFACE PROTEIN SITES OF NEISSERIA MENINGITIDIS AS EPITOPES FOR STRAIN-SPECIFIC VACCINES OR BROAD-STRAIN (UNIVERSAL) VACCINES

The gram-negative Neisseria Meningititis (NM) remains a significant microbial problem and particularly lethal for the very young. Serogroup B strains are particularly troublesome an more...

Supervisor(s): Lynch, Garry (Dr)