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Developing new antibiotics by targeting specific molecular interactions in bacteria

This project focuses on developing a new class of antibiotics by targeting specific molecular interactions in bacteria using a multi-disciplinary fragment-based drug design approach more...

Supervisor(s): Kwan, Ann (Dr)

TARGETING THE BRAIN VASCULATURE AS A TREATMENT FOR CEREBRAL TYPE I INTERFERONOPATHIES

Abnormal blood vessels are feature of cerebral type I interferonopathies. Discover how the endothelial cells that line the brain’s blood vessels contribute to disease in patie more...

Supervisor(s): Hofer, Markus (Dr)

The primary cilia in diabetic kidney disease: targeting the cellular antennas

This project explores the role of the kidney proximal tubule cell primary cilia in diabetic nephropathy. Diabetic kidney disease is a leading cause of end stage kidney disease, requ more...

Supervisor(s): Panchapakesan, Usha (Associate Professor)

Targeting Rab7 and TBC1D15 to overcome mitochondrial dysfunction in neurological diseases

Pharmacological manipulation of contacts between mitochondria and LE/Lys could provide opportunities to improve PD, CMT2B and NPC disease. Virtual screening of compound libraries wi more...

Supervisor(s): Grewal , Thomas (Associate Professor), Groundwater, Paul (Professor), Hibbs, David (Dai) (Professor)

Chemical synthesis and phenotypic validation of precision proteolysis targeted chimeras (PROTACs) for cancer and cardiovascular disease

Emerging from the interface between chemistry and biology, chemical biology has led to the establishment of several game-changing drug discovery paradigms. Among these revolutionary more...

Supervisor(s): Liu, Xuyu (Dr), Payne, Richard (Professor)

Brain Cancer and Hypoxia

Aggressive brain tumours, including adult glioblastomas and pediatric DIPGs, are difficult to treat. Survival rates have improved very little over the last 30 years indicating a nee more...

Supervisor(s): Cook, Kristina (Dr)

Organometallics and Catalysis

The projects will focus on novel monometallic and multimetallic transition metal catalysts as well as new methodologies for catalysis and developing surface supported catalysts. The more...

Supervisor(s): Messerle, Barbara (Professor)

Dissecting the architecture of the Insulin Signaling Pathway

The aim of this pathway is to understand how the insulin signalling pathway regulates metabolic homeostasis.The Lead Supervisor for this project is David James. This project will a more...

Supervisor(s): James, David (Professor)