Stem cells in the body occupy a complex environment with soluble factors and extracellular matrix proteins. We aim to understand the interplay between biochemical and biomechanical signals that drive the defining properties of stem cells. We want to characterise the molecular processes that regulate diverse aspects of regenerative function, including proliferation, plasticity, targeted differentiation, immunomodulation, and cellular ageing.
We also aim to develop new technologies for effective stem cell manipulation, based on our evolving understanding of stem cell biology. Together with our collaborators in the fields of biomaterials, biofabrication, surface engineering, and computational modelling, we are creating biomimetic platforms for high-yield, robust stem cell expansion and differentiation, and functional materials that instruct or interface with regenerative stem cells for enhanced tissue repair.
We have accumulating evidence that mesenchymal stromal cell behaviour can be effectively regulated by an elastic extracellular matrix component known as tropoelastin. We are using a combination of functional assays and multi-omic analyses to understand the molecular underpinnings and regulatory effects of tropoelastin on cell regenerative properties.
We are studying the processes that lead to age- and stress-induced cellular senescence. Together with biomedical engineers, we are developing platforms that can recapitulate cellular ageing in vitro, and are using nanotechnologies to delay or alleviate senescent hallmarks to improve the functional lifespan of regenerative cells.
Together with material engineers, we are developing a range of materials decorated with bio-instructive cues that enhance stem cell expansion, promote targeted differentiation, or preserve stem cell phenotype, for improved tissue repair.
Please email Associate Professor Giselle Yeo to discuss collaborations or PhD/Honours projects.
