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About the centre

A world-first centre tackling substance use and mental disorders
The Matilda Centre for Research in Mental Health and Substance Use is a multidisciplinary research centre committed to improving the health and wellbeing of people affected by co-occurring substance use and mental disorders.

Established in 2018, the Matilda Centre for Research in Mental Health and Substance Use aims to generate innovative and workable solutions to address substance use and mental disorders, which are currently the leading global causes of burden and disease in young people.

We work closely with research collaborators to share skills, synergise data and harness new technologies to develop and trial innovative prevention and early-intervention programs for co-occurring substance use and mental disorders.

We’re committed to

  • bringing together globally recognised researchers with a shared commitment to the prevention, early intervention and treatment of mental and substance use disorders
  • leading research to build the evidence base for a thriving and empowered younger generation
  • engaging with decision-makers and people with lived experience to enact real change
  • acting as a focal point and link between University of Sydney researchers, policy leaders and clinicians.

We facilitate collaboration

Our people are leading Australian and international researchers in addiction, mental health and youth health and our work builds dynamic, creative and global collaborations.

We invite those who share our mission to find workable solutions to prevent and treat comorbid mental health and substance use disorders to contact us.

We’re supervisors and mentors too

As leaders in our fields, we are proud to be educating a new generation of researchers, practitioners and teachers so that they too can think differently about substance use and mental health disorders.

We offer a range of opportunities for research students and early career researchers to study or work with us and receive mentorship from our internationally recognised researchers.

We can help you upskill

We also offer a range of training programs and resources for clinicians, school staff, families and the community to facilitate knowledge exchange around mental health and substance use, with the aim of improving support and changing lives.


Join us in our mission to help youth across the globe who are struggling with substance use or mental health by getting in touch.

Related articles

16 April 2021

Anxiety and alcohol use: Can we Re-Train Your Brain?

Researchers at the Matilda Centre are running a pilot trial to examine whether an online brain training program can successfully re-train spontaneous and sometimes subconscious mental habits that contribute to the development and maintenance of anxiety and alcohol use disorders.
16 April 2021

Treating post-traumatic stress and substance use disorders in adolescents

We spoke to Dr Natalie Peach about an innovative treatment program for youth targeting post traumatic stress disorder and substance use.
16 April 2021

How does childhood trauma impact problematic eating and substance use among adolescents?

We spoke to Ivana Kihas about her PhD journey with the Matilda Centre and her work in co-occuring post traumatic stress disorder, substance use and eating disorders.
23 March 2021

The Matilda Centre celebrates outstanding achievements

The Matilda Centre has held the inaugural 'Matilda Centre Awards', recognising outstanding achievement in activities that promote the values and aims of the Matilda Centre in 2020.
05 February 2021

2020 PREMISE Research Seed Funding Awards

Research seed funding grants have been awarded to two University of Sydney researchers to support innovation, collaboration and enhance future funding submissions.

01 February 2021

New year and a new look for Positive Choices

Significant changes have been made to the Positive Choices portal to make it easier for students, school staff, parents and families to find trusted, evidence-based information, resources and prevention programs.
27 January 2021

Seeking feedback on a resource for Aboriginal and Torres Strait Islander health

Researchers from the Matilda Centre are seeking feedback on a recently developed resource to support Aboriginal and Torres Strait Islander health and wellbeing.

18 December 2020

Media mentions

We are regularly engaged in wider public discussion around mental health, substance use and other related topics.
18 December 2020

Another successful year for PREMISE

The PREMISE NHMRC Centre of Research Excellence in Prevention and Early Intervention in Mental Illness and Substance Use has had another successful year training future leaders and providing opportunities for collaboration.
16 December 2020

Alone Together study

Researchers at the University of Sydney are investigating how the COVID-19 pandemic has impacted the lives of Australians.