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Defining the genetic link between nitrate and ammonium transport proteins and root architecture in Maize and Barley

We have previously tested two contrasting maize inbred lines on their inherent nitrate transport rates and respective responses to growth at low nitrogen supply. The lines were sele more...

Supervisor(s): Kaiser, Brent (Professor)

Role of Protein Phosphorylation in Cellular Function

Using advances in mass spectrometry-based proteomics this project aims to uncover how phosphorylation affects the function of proteins and cells in both healthy and diseased states. more...

Supervisor(s): James, David (Professor)

A structural view and understanding of NPF (nitrate transport) protein activity in maize

This PhD project will develop and analyse high quality crystallised proteins of the nitrate/chloride transport proteins ZmNPF6;4, ZmNPF6;4 (Y370H) and ZmNPF6;6. The goal will be to more...

Supervisor(s): Kaiser, Brent (Professor)

Dissecting the architecture of the Insulin Signaling Pathway

The aim of this pathway is to understand how the insulin signalling pathway regulates metabolic homeostasis.The Lead Supervisor for this project is David James. This project will a more...

Supervisor(s): James, David (Professor)

PRECLINICAL AND CLINICAL DEVELOPMENT OF NOVEL BONE-BINDING ANTIMICROBIALS

Our team has spent several years developing and testing new a new class of drugs termed bone-binding antimicrobials (BBAs). Our lead compound (BBA-1) has been shown to have antimicr more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Little, David (Professor)

Define regulatory control pathways delivering NPF (nitrate) and AMT (ammonium) transport activities across root types and cell profiles

We have previously identified the tissue expression patterns of ZmNPF6;6 and ZmNPF6;4 in maize root tips (Wen, Z., et al., The Plant Cell, 2017) and used qPCR as well as custom arra more...

Supervisor(s): Kaiser, Brent (Professor)

Developing new antibiotics by targeting specific molecular interactions in bacteria

This project focuses on developing a new class of antibiotics by targeting specific molecular interactions in bacteria using a multi-disciplinary fragment-based drug design approach more...

Supervisor(s): Kwan, Ann (Dr)

Using metabolomics and other omics to guide new cancer therapies

This project will investigate cellular status and signaling in novel cancer therapies, especially new irradiation schemes in radiotherapy using metabolomics, transcriptomics and pro more...

Supervisor(s): Kwan, Ann (Dr), McKenzie, David (Professor)

NANOPARTICLE-BASED BIOMOLECULE DETECTION SYSTEMS

You will develop novel systems to detect biomolecular expression profiles for use in imaging and flow cytometry. This multidisciplinary project aims to improve our understanding of more...

Supervisor(s): Fraser, Stuart (Dr)

Green Chemistry - Biocatalysis For Production Of High-Value Chemicals

The ultimate aim of biocatalysis research is to replace the petrochemical industry with clean and green microbial reactions using renewable and non-toxic feedstocks. But how exactly more...

Supervisor(s): Coleman, Nicholas (Associate Professor), Rutledge, Peter (Professor)