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Biology of Dipeptidyl Peptidase IV and related proteins

Research projects centre on mouse models of liver disease and obesity and on the delineation of inhibitors, substrates, biochemistry and in vivo expression and function of the Dipep more...

Supervisor(s): Gorrell, Mark (Associate Professor)

Preventing rejection of transplanted organs without using immunosuppressive drugs

The project aims to identify molecular pathways to prevent rejection of transplanted organs in animal models and to apply these findings to clinical transplantation. more...

Supervisor(s): Bishop, Alex (Dr)

Drug Discovery and Medicinal Chemistry for the Central Nervous System

Projects involve developing novel CNS drugs through applications of organic synthesis, medicinal chemistry and pharmacological screening. more...

Supervisor(s): Kassiou, Michael (Professor)

Mechanisms of T cell migration and interactions in the tumor microenvironment

The project will use intravital two-photon microscopy to determine the molecules involved in interstitial T cell migration and the molecular mechanisms of T cell interactions with t more...

Supervisor(s): Weninger , Wolfgang (Professor)

Stemming vision loss with stem cells

Studies to maximise recruitment of hematopoietic stem cells in various experimental models of retinopathy. more...

Supervisor(s): Chan-Ling, Tailoi (Professor)

The transformation of normal melanocytes into melanoma

This project investigates the role of the oncogenes Ras and Braf and the tumour suppressors p16INK4a, p14ARF, p53 and PTEN in the malignant transformation of melanocytes. more...

Supervisor(s): Kefford, Richard (Professor)

The role of regulatory T Lymphocytes in aberrant human immune responses

The focus is to phenotypically and functionally characterise T regulatory cells in aberrant immune responses  e.g. autoimmune and allergic diseases. more...

Supervisor(s): Nanan, Ralph (Professor)

Interactions between porcine ligands and the human lymphocyte activating receptor NKG2D

Role of NKG2D in the human cellular immune response against porcine xenotransplants. more...

Supervisor(s): Sharland, Alexandra (Dr)

Regulating prosclerosing growth factors by incretin therapy in diabetic cardiomyopathy

Growth factors induced by diabetes contribute to tissue fibrosis and dysfunction, in conditions such as diabetic cardiomyopathy, and there is preliminary evidence that the incretins more...

Supervisor(s): Twigg, Stephen (Professor)

Bioinformatics approach to Cryptosporidium identity: database prospects

The Bioinformatics approach to Cryptosporidium identity: database prospects study will examine (i) the applicability of web based platform to clinical and field data and (ii) develo more...

Supervisor(s): Slapeta, Jan (Professor)