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Targeting Rab7 and TBC1D15 to overcome mitochondrial dysfunction in neurological diseases

Pharmacological manipulation of contacts between mitochondria and LE/Lys could provide opportunities to improve PD, CMT2B and NPC disease. Virtual screening of compound libraries wi more...

Supervisor(s): Grewal , Thomas (Associate Professor), Groundwater, Paul (Professor), Hibbs, David (Dai) (Professor)

THE PATHOGENIC AND PROTECTIVE EFFECTS OF MICROGLIA IN CEREBRAL CYTOKINOPATHIES

Microglia are the primary immune cells of the brain and have the potential to both protect and contribute to neurological disease. Explore the molecular mechanisms that microglia us more...

Supervisor(s): Hofer, Markus (Dr)

Conserved Regulatory Genes in Neurodevelopment

The present project aims to utilize the promising combination of 3D organoid technology and CRISPR genome editing, which will allow us to examine the roles of several conserved gene more...

Supervisor(s): Neely, Greg (Professor)

Cumulative modeling of Maternal Immune Activation to assess risk factors of common neurodevelopmental disease

Neurodevelopmental disorders such as epilepsy, autism, Tourette syndrome or ADHD affect 10% of children. There is increasing evidence that maternal inflammation whilst pregnant, ter more...

Supervisor(s): Hofer, Markus (Dr)

TARGETING THE BRAIN VASCULATURE AS A TREATMENT FOR CEREBRAL TYPE I INTERFERONOPATHIES

Abnormal blood vessels are feature of cerebral type I interferonopathies. Discover how the endothelial cells that line the brain’s blood vessels contribute to disease in patie more...

Supervisor(s): Hofer, Markus (Dr)

HOW DIFFERENT CELL TYPES OF THE BRAIN CONTRIBUTE TO CEREBRAL CYTOKINOPATHIES

The brain consists of a large number of different cell types, including neurons, astrocytes, oligodendrocytes, microglia and endothelial cells. Discover how these different cell typ more...

Supervisor(s): Hofer, Markus (Dr)

EFFECTS OF TYPE I INTERFERONS IN CHRONIC VIRAL INFECTIONS

When type I interferon signalling is impaired, infection with lymphocytic choriomeningitis virus results in chronic infection and dysfunctional CD8+ T cell function. Investigate how more...

Supervisor(s): Hofer, Markus (Dr)

Gene editing of stem cells or cancer to develop new stem cell therapies to treat human disease

This project involves the use of human stem cells and CRISPR genome editing to study basic signalling pathways controlling stem cell differentiation and/or cancer. A compliment more...

Supervisor(s): Neely, Greg (Professor)

Gene editing of human stem cells and to better understand chronic pain disease

This project involves the use of human stem cells to generate pain sensing neurons and CRISPR gene editing to identify new pain killers. A complimentary scholarship for this pr more...

Supervisor(s): Neely, Greg (Professor)

Artificial Intelligence in Ion Channel Drug Discovery

Application of machine learning and artificial intelligence methods to develop models predictive of drug activity, selectivity, stability and distribution. The project will be condu more...

Supervisor(s): Balle, Thomas (Associate Professor)