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Predicting the future risk of chronic kidney disease in offspring of obese mothers with and without type 2 diabetes

Chronic kidney disease (CKD) is a major health burden driven mostly by obesity and type 2 diabetes mellitus. 1/3 of diabetic patients are at risk of CKD progression for unknown reas more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

Monocyte re-programming with increased cardiovascular disease risk

Cardiovascular disease (CVD) is the leading cause of death in Australia and an increasing number of people live with the condition. The main underlying cause is atherosclerosis, the more...

Supervisor(s): Medbury, Heather (Dr)

Novel therapies for preventing kidney failure in chronic kidney disease

PhD and Master of Phil opportunities, at Centre for Transplantation and Renal Research, Westmead Institute for Medical Research, Westmead Clinical School, Faculty of Medicine and He more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

Novel therapy to prevent and treat kidney fibrosis

Progressive kidney disease is a global health burden most commonly caused by diabetes and obesity, which are dramatically on the rise. In Australia, 1 in 3 adults are at risk of dev more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

Pathways to therapies in blinding genetic retinal eye diseases

In this project, novel disease genes and variants are identified that cause blinding retinal eye diseases. Cellular, gene editing, proteomic and animal model approaches are taken to more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

Pharmacological targeting of the metastasis suppressor NDRG1 using novel therapeutics

Metastasis is the major killer in cancer, being extremely difficult to treat. This project will elucidate the molecular mechanisms that initiate and sustain metastatic progression, more...

Supervisor(s): Kovacevic, Zaklina (Dr), Richardson, Des (Professor)

Utilising Clinically Relevant Mechanisms to Develop Neuroprotective Strategies in Glaucoma

Neuroprotective strategies for glaucoma therapy have been investigated extensively over the last few years with disappointing clinical trial results. However a significant proportio more...

Supervisor(s): White, Andrew (Dr)

The Renin-Angiotensin System and its Role in Neuroprotective Strategies in a Glaucoma Model

At present, the only treatment for glaucoma is intraocular pressure control. We know some people still get worse despite good pressure control. We have evidence that a system previo more...

Supervisor(s): White, Andrew (Dr)

The New Renin-Angiotensin System in the Human Eye

At present, the only treatment for glaucoma is intraocular pressure control. We know some people still get worse despite good pressure control. We have evidence that a system previo more...

Supervisor(s): White, Andrew (Dr)

PET imaging of glioma in a TSPO knockout model

Glioblastoma is the most frequent primary brain tumour and the most malignant glial neoplasm (glioma) with predominantly astrocytic differentiation. Due to their invasive nature, gl more...

Supervisor(s): Graeber, Manuel (Professor), Banati, Richard (Professor)