Your Search Results

Characterising changes in a proteome of islets and islet cell types during progression to type 2 diabetes

Characterizing changes in a proteome through pathogenesis of diseases can provide unparalleled insights into the mechanisms underpinning disease. In this project, using flow cytomet more...

Supervisor(s): Kebede, Melkam (Dr)

Predicting the future risk of chronic kidney disease in offspring of obese mothers with and without type 2 diabetes

Chronic kidney disease (CKD) is a major health burden driven mostly by obesity and type 2 diabetes mellitus. 1/3 of diabetic patients are at risk of CKD progression for unknown reas more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

RNA-based biomarkers to understand and predict disease progression

RNA-based biomarkers are becoming increasingly important due to their stability and sensitivity of detection. This project will use in vitro, in vivo and clinical sample analysis b more...

Supervisor(s): Hardikar, Anandwardhan (Associate Professor)

Reversing the human Famine Reaction via diet and high intensity exercise

This project aims to determine whether a higher protein and lower glycaemic index weight maintenance diet, combined with high intensity physical activity, can attenuate the strength more...

Supervisor(s): Salis, Amanda (Associate Professor)

Characterising insulin secretory granules as a function of age

In β-cells, insulin is stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that SGs exist in two functionally distin more...

Supervisor(s): Kebede, Melkam (Dr)

Sorting proinsulin into secretory vesicles

Reduction in glucose-stimulated mature insulin secretion and increased constitutive and regulated secretion of proinsulin are characteristics of β-cell failure. This may be due more...

Supervisor(s): Kebede, Melkam (Dr)

Novel therapy to prevent and treat kidney fibrosis

Progressive kidney disease is a global health burden most commonly caused by diabetes and obesity, which are dramatically on the rise. In Australia, 1 in 3 adults are at risk of dev more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

Immuno-metabolism of macrophages in inflammatory diseases

In metabolic organs like the liver and fat, macrophage infiltration plays a pivotal role in driving low-grade chronic inflammation that results in many of the consequences of obesi more...

Supervisor(s): George, Jacob (Professor)

Nutrient regulation of the stem cell compartment

Australia is among the countries with the fastest growing rates of overweight and obesity, which by 2025 will affect >70% of the population. Chronic diseases linked to obesity in more...

Supervisor(s): George, Jacob (Professor)