We turn pioneering research into real-world impact. Our diverse portfolio of innovations is ready for licensing, collaboration, and investment—spanning diagnostics, therapeutics, biomedical devices, optical technologies and more.
| Summary | An antibody targeting Myc, with the potential to disrupt this otherwise "undruggable" target in various cancers. 2024-078 |
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| Inventors | Dr Mahdi Zeraati, Prof Marcel Dinger |
| Contact | julius.juarez@sydney.edu.au |
| Summary |
2023-117 |
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| Inventor | Matthew Thomas Doyle, Alfred Hartojo, Peggy Cotter, Richard Johnson |
| Contact | julius.juarez@sydney.edu.au |
| Summary | Antisense oligonucleotides that reduce translation of inflammatory signalling proteins through a novel mechanism. 2025-130 |
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| Inventors | A/Prof Justin Wong, Natalia Pinello, Jessica Tieng |
| Contact | julius.juarez@sydney.edu.au |
| Summary | A novel peptide-based technology disrupts immune complexes to prevent life-threatening blood clots caused by Heparin-induced thrombocytopenia (HIT), vaccine-induced thrombotic thrombocytopenia (VITT), and VITT-like diseases. All are severe immune reactions that cause catastrophic blood clots. 2024-115 Project details (pdf, 154KB) |
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| Inventors | Freda Passam, Xuyu Liu, Jose Sail Perdomo |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | A small device designed to mimic the appearance of hair, capable of interfacing with the brain for sensing, actuation, and as a delivery mechanism. 2024-059 |
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| Inventors | Omid Kavehei |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | A number of novel transcription factors associated with functional CAR-T cell phenotypes and proliferation, and methods of identifying more. 2023-120 |
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| Inventors | Salvatore Fiorenza, Cameron Turtle |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | This invention is a new copper-sensing molecular probe with applications for early diagnosis of Parkinson’s disease and management of amyotrophic lateral sclerosis. 2025-135 Project details (pdf, 210KB) |
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| Inventors | Professor Elizabeth New, Professor Kay Double, Marcus Graziotto, Dr Liam Adair |
| Contact | julius.juarez@sydney.edu.au |
| Summary | A modified silica nanoparticle composition for bone regeneration. 2025-135 |
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| Inventors | Chun Xu, Chang Lei, Chengzhong Yu |
| Contact | julius.juarez@sydney.edu.au |
| Summary | Multispectral analysis of urinary biomarkers to non-invasively identify acute tubular necrosis, graft rejection, and non-rejection associated interstitial fibrosis and tubular atrophy. 2024-019 Project details (pdf, 150KB) |
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| Inventors | Sonia Saad, Caroll Pollock, Ewa Goldys, Hon Lin Henry Wu, Yandong Lang |
| Contact | akshita.wason@sydney.edu.au |
| Summary | A patient-specific microfluidic carotid artery platform that replicates vascular injury and blood flow conditions to assess thrombotic risk and evaluate antithrombotic therapies. The technology enables personalised stroke risk prediction and treatment selection using clinically relevant models of individual vascular biology. 2024-101 |
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| Inventors | Professor Arnold Lining Ju, Timothy Ang, Freda Passam, Yunduo Zhao, Zihao Wang |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | A bioengineered silk-based platform that recreates the changing mechanical properties of human tissues over time, enabling more physiologically relevant in vitro models of ageing, injury, fibrosis, and cancer. The technology provides a dynamic environment for studying disease progression and therapeutic responses. 2026-025 |
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| Inventors | Professor Khoon Lim, Habib Joukhdar, Giselle Yeo |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | A novel mRNA therapeutic platform that enhances the body's innate antiviral defenses through engineered TLR3 variants. Delivered using lipid nanoparticles, the technology is designed to provide broad-spectrum protection against multiple RNA viruses and may offer a new class of antiviral medicines. 2023-073 |
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| Inventors | Professor Greg Neely, Rebecca Carr, Lipin Loo, Christopher Denes, Cesar Moreno |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | A generative AI platform creates biologically constrained digital twins of microfluidic experiments. By integrating device geometry, localised stimuli and experimental conditions, it produces time-resolved microscopy simulations to predict biodynamic responses, support experimental planning and reduce reliance on repeated laboratory testing. 2026-072 |
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| Inventors | Professor Arnold Lining Ju, Haimei Zhao, Yunduo Zhao, Zihao Wang, Nicole Yap |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | A series of new ligands that exhibit significantly higher affinity for a biomarker of neuroinflammation. 2022-013 |
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| Inventors | Dr Jonathan Danon, Professor Michael Kassiou, Greta Sohler, Dr Renee Sokias, Dr Tristan Reekie, Dr Eryn Werry |
| Contact | julius.juarez@sydney.edu.au |
| Summary | A novel software to increase CT image quality thereby improving accuracy and decreasing patient radiation dose. 2021-022, 2020-040, 2013-018 |
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| Inventors | Natasha Morton, Ricky Thomas O'Brien, Paul Keall, Jeffrey Barber, Jonathan Sykes, John Kipritidis |
| Contact | akshita.wason@sydney.edu.au |
| Summary | A novel algorithm that quantifies immune activity across solid tumours to inform clinical decisions about immunotherapy use. 2025-154 Project details (pdf, 150KB) |
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| Inventors | Dr Yuchen Feng, Ran Xu |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | This invention relates to new phage-drug nanoconjugates for combating bacterial infections. 2021-070 |
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| Inventors | Professor Jonathan Iredell, Dr Hien Thi Duong, Huiping Huang |
| Contact | julius.juarez@sydney.edu.au |
| Summary | A novel software capable of predicting 3D lung motion with only 10 x-ray projections, for large scale lung disease screening. 2024-032 Project details (pdf, 213KB) |
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| Inventors | Paul Keall, Hunor Kertesz, Owen Dillon, Hilary Byrne, Ricky O'Brien |
| Contact | akshita.wason@sydney.edu.au |
| Summary | X-ray guided cardiac radioablation as a precise, non-invasive treatment for cardiac arrhythmias, using diaphragm-tracking algorithms to adjust for respiratory motion. 2020-034 |
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| Inventors | Paul Keall, Nicholas Hindley, Suzanne Lydiard, Dr Chun-Chien Shieh |
| Contact | akshita.wason@sydney.edu.au |
| Summary | A novel phage extracellular vesicle (EV) conjugate designed to promote tissue repair in individuals with bacterial infections. 2022-041 |
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| Inventors | Professor Wojciech Chrzanowski, Dr Hien Thi Duong |
| Contact | julius.juarez@sydney.edu.au |
| Summary | This invention relates to peptide mimetic compounds, inspired by the natural healing capabilities of PDGF but engineered to circumvent the pitfalls of prolonged exposure that can lead to fibrosis. 2021-091 |
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| Inventors | A/Professor James Chong, Emily McKinna, Professor Richard James Payne, Daniel Ford, Richard Harvey, Dr Osvaldo Contreras |
| Contact | julius.juarez@sydney.edu.au |
| Summary | An instrumented spinal tool that uses intraoperative measurements and a reference database to guide optimal spinal cage sizing. 2025-032 Project details (pdf, 124KB) |
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| Inventors | Ahmed Mounir Boudali, Elizabeth Clarke, Taha Shakoh, YH Yau, Bill Walter |
| Contact | julius.juarez@sydney.edu.au |
| Summary | Researchers have identified naturally occurring high molecular weight proteins in feline secretions that trigger innate fear and avoidance behaviours in rodents. The technology aims to translate these predator-derived biological signals into a safe, non-lethal rodent repellent for urban, domestic, industrial, and agricultural environments. 2025-057 Project details (pdf, 171KB) |
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| Inventors | Professor Iain McGregor, Miguel Bedoya-Perez |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | This technology is a tunable hydrogel microcarrier platform that enables controlled, sustained delivery of therapeutic molecules. It supports regenerative medicine, wound healing and cell therapy applications through customisable therapeutic release and degradation profiles. 2025-020 |
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| Inventors | Professor Khoon Lim, Kieran Yan Ki Lau, Khanh Vinh Doan, Renjian Tan |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | A novel software capable of tracking the movement of multiple targets during radiation therapy. 2023-124 |
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| Inventors | Emily Hewson, Paul Keall, Owen Thomas Dillon, Jeremy Booth |
| Contact | akshita.wason@sydney.edu.au |
| Summary | A rapid, low-input sample-to-sequencing workflow that simplifies cfDNA library preparation, enabling faster, lower-cost, and more scalable liquid biopsy and sequencing applications. 2026-026 |
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| Inventors | Zac Chatterton |
| Contact | jeremy.cohen@sydney.edu.au |
| Summary | A targeted TNBC (Triple Negative Breast Cancer) therapy with increased selectivity and efficacy and decreased toxicity. 2018-115 |
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| Inventors | Pegah Varamini, Sepideh Khazeni |
| Contact | julius.juarez@sydney.edu.au |
| Summary | A small molecule that reduces cholesterol accumulation in Neimann Pick Type C patient cells. 2026-011 |
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| Inventors | Associate Professor Thomas Grewal, Professor David Hibbs, Professor Paul Groundwater, Associate Professor Andrew Hoy, Dr Eric Sparkes, Dr Jonathan Du, Ms Mai K.L. Nguyen. |
| Contact | akshita.wason@sydney.edu.au |
| Summary | The innovation at hand is a nanoparticle bioconjugate that employs a dual-nanoparticle approach to target and bind to both cancer cells and immune cells. 2021-052 |
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| Inventors | A/Professor Veysel Kayser, Mariam Tarkistani |
| Contact | julius.juarez@sydney.edu.au |
| Summary | A new gene editing technology that offers enhanced precision and the capability to insert large DNA sequences without off-target mutations or triggering error-prone DNA repair. 2023-023 Project details (pdf, 150KB) |
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| Inventors | Sandro F Ataide, Rezwan Siddiquee, Ruth Hall |
| Contact | jeremy.cohen@sydney.edu.au |
| Summary | This invention presents a new method for assembling protein cages outside of cells, without the need for disassembly. The technology offers greater reliability, flexibility, and consistency compared to existing methods, as well as simplifying manufacturing processes, making it well-suited for applications in therapeutics, vaccines and more. 2024-035 Project details (pdf, 2.2MB) |
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| Inventors | A/Prof Yu Heng Lau, Dr Taylor Szyszka and PhD candidate Rezwan Siddiquee |
| Contact | jeremy.cohen@sydney.edu.au |
| Summary |
2023-080 |
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| Inventors | Hak-Kim Chan, Dipesh Khanal |
| Contact | lulu.xue@sydney.edu.au |
| Summary | This technology provides an advanced water treatment platform designed to achieve direct destruction of PFAS contaminants in water. 2025-104 |
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| Inventors | John Matthew Kavanagh, Susanna Kurian, David Alam, Patrick Cullen |
| Contact | lulu.xue@sydney.edu.au |
| Summary |
2025-144 |
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| Inventors | Hoang Thien Nguyen, Michael Rubin, Sarah Askey, Erik Muller, Fraser Hamersley, Daniel Mooney, Khalid Rafique, Salah Sukkarieh, Eric Dreischerf, Matthew Imhoff |
| Contact | lulu.xue@sydney.edu.au |
| Summary |
2026-075 |
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| Inventors | Seyed Ali Hadigheh, Yunyun Tao |
| Contact | lulu.xue@sydney.edu.au |
| Summary | This technology chemically modifies polyhydroxyalkanoates by bonding them with polyamines to enhance their thermal, mechanical, and processing properties for advanced biomedical applications. 2024-100 |
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| Inventors | Dr Sepehr Talebian, Chen Wang, Prof. Fariba Dehghani, A/Prof Sina Naficy |
| Contact | lulu.xue@sydney.edu.au |
| Summary | Innovative organic semiconductor nanoparticles designed to mimic human retinal photoreceptors for advanced retinal prosthetic applications. 2023-029 |
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| Inventors | A/Professor Matthew Griffith, A/Professor Rebecca Lim |
| Contact | lulu.xue@sydney.edu.au |
| Summary | A technology that adds low cost and simple architecture to the existing advantages of photonics-based radar. 2020-004 Project details (pdf, 50KB) |
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| Inventors | Dr Yang Liu, Mr Ziqian Zhang, Professor Benjamin Eggleton |
| Contact | jeremy.cohen@sydney.edu.au |
| Summary | An innovative method and system utilizing microbial enzyme-mediated hydrolysis combined with pre-treatment and post-treatment processes to efficiently recycle fibre-reinforced polymers into high-quality carbon and glass fibres. 2024-044 |
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| Inventors | Dr Ali Hadigheh, Yaning Wei |
| Contact | lulu.xue@sydney.edu.au |
| Summary | A water-soluble, wash-free fluorescent probe that selectively binds choline-containing lipids in the plasma membrane, enabling rapid live-cell imaging and analysis of membrane organisation. 2026-070 Project details (pdf, 125KB) |
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| Inventors | Professor Kate Jollife, Dr. Jingyao You |
| Contact | jeremy.cohen@sydney.edu.au |
| Summary | This invention is a portable optical detection system that uses a functionalised tapered optical fibre sensor to identify pathogens or viruses. 2021-068 |
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| Inventors | Ken-Tye Yong |
| Contact | lulu.xue@sydney.edu.au |
| Summary | This technology provides plasma enhanced chemical vapour deposited (PECVD) films containing carbon, oxygen and optionally nitrogen, with patterned regions of differing electrical conductivity. 2023-069 |
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| Inventors | Marcela Bilek, Clara Thao Hoang Tran, Aaron Gilmour, David Robert McKenzie, Sophie Cottam |
| Contact | lulu.xue@sydney.edu.au |
| Summary | This technology provides a renewable bioplastic platform derived from protein-based feedstocks that offers a sustainable alternative to conventional plastic materials. 2025-097 Project details (pdf, 90KB) |
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| Inventors | Yi Shen, Luke Sorenson |
| Contact | lulu.xue@sydney.edu.au |
| Summary | An improved protein coating process that enables covalent attachment of any protein to a glass surface without using chemical linkers or any additional reagents, which could drive growth in the global medical coatings market. 2021-134 Project details (pdf, 150KB) |
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| Inventors | Professor Marcela Bilek, Dr Clara Thao Hoang Tran, Dr Stuart Tallis Fraser, Dr Badwi Bob Boumelhem, Dr Aaron Gilmour |
| Contact | lulu.xue@sydney.edu.au |
| Summary | ADAPT-MH is an adaptive digital mental health assessment platform that rapidly evaluates multiple mental health domains using advanced statistical modelling. By dynamically selecting the most informative questions, it generates clinically interpretable results while reducing assessment burden, supporting more efficient screening, triage, and monitoring. 2026-007 |
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| Inventors | Professor Ian Hickie, William Capon, Frank Iorfino, Mathew Varidel. |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | A board game that helps medical, nursing, and allied health students understand how social, economic, and environmental factors affect rural patient outcomes in Australia. 2023-105 |
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| Inventors | Dr Heather Russel, Dr Christopher Harrison, Lisa Hampshire, Dr Marguerite Tracy, Professor Annette Burgess, Dr Matthew Tyne. |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | An AI-driven predictive analytics platform that learns from longitudinal mental health assessment data to forecast individual illness trajectories, quantify risk and uncertainty, and generate personalised insights that support clinical decision-making, monitoring strategies, and more proactive mental healthcare delivery. 2026-050 |
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| Inventors | Professor Ian Hickie, Frank Iorfino, Mathew Varidel |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | A framework designed to support emergency nurses in assessing and managing emergency department patients after triage. 2022-016 Project details (pdf, 170KB) |
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| Inventors | Belinda Kennedy, Julie Considine, Kate Curtis, John Mackenzie, Margaret Murphy, Sarah Kourouche, Margaret Fry, Ramon Shaban |
| Contact | commercialisation@sydney.edu.au |
| Summary | An adaptation of the original HIRAID framework for residential aged care. |
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| Inventors | Professor Ramon Shaban, Dr Catherine Viengkham, Professor Kate Curtis AO, Professor Julie Considine AO (Deakin University), Professor Margaret Fry AM (UTS) |
| Contact | commercialisation@sydney.edu.au |
| Summary | A custom-designed web-based platform for automating the administration of the Indigenous Tutorial Assistance Scheme-Tertiary Tuition (ITAS-TT). 2021-003 |
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| Creators | Designed at the University of Sydney by the Office of the DVC (Indigenous Strategy and Services) and developed by TechLab in Information and Communication Technology (ICT) |
| Contact | commercialisation@sydney.edu.au |
| Summary | An online program that provides peer support tools, mental health literacy content and help seeking guidance for teenagers. 2025-155 |
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| Creators | Dr Louise White, Sophia Spallek, Ms An Nguyen, Ms Ainsley Furneaux‑Bate. |
| Contact | emma-louise.hunsley@sydney.edu.au |
| Summary | PEDro is a globally recognised evidence platform that curates, appraises, and delivers physiotherapy research findings through a freely accessible online database. It enables clinicians, educators, researchers, and policymakers to rapidly identify high-quality evidence and support evidence-based healthcare decision-making. 2025-040 |
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| Inventors | Christopher Maher, Rob Herbert |
| Contact | emma-louise.hunsley@sydney.edu.au |
Commercialisation team
Our Commercialisation team is here to help you navigate licensing, collaboration and investment opportunities, so you can bring innovation to life.