Through collaborative research and industry partnerships, the Mechanobiology and Biomechanics Laboratory aims to translate discoveries into tangible healthcare solutions.
The Mechanobiology and Biomechanics Laboratory (MBL) is at the forefront of research in mechanobiology, biomechanics and biomanufacturing. Led by Associate Professor Arnold Ju, the team is dedicated to advancing scientific knowledge and improving healthcare outcomes through the development of cutting-edge microtechnologies for cardiovascular health.
The lab is actively involved in international collaborations and partnerships, including:
The Snow fellowship funds Associate Professor Ju’s research program aimed at understanding the mechanics behind blood clot formation, which carries profound implications for diagnosing and preventing heart attacks and strokes.
Developing innovative biomechanical nanotools, such as the Biomembrane Force Probe (BFP) and fluorescent micropipette aspiration assays (fMPA), to elucidate cellular responses to mechanical stress and advance understanding of mechanobiological mechanisms in cardiovascular diseases.
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Pioneering personalised organ-on-a-chip devices, such as vessel-on-chip models, to simulate prothrombotic vascular geometries and provide insights into thrombosis and endothelial behaviour under stenotic conditions. These platforms aim to revolutionise drug evaluation and enhance the success rate of therapeutic interventions.
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Leveraging expertise in mechanobiology and biomanufacturing to translate research findings into clinical applications through collaborations with leading clinical trial centres and industry partners. Addressing regulatory considerations and securing clinical champions to ensure the successful translation of technologies from concept to commercialisation.
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Develop an AI algorithm to aid the automation of 3D microprinting these vessel-chips, through both MRV segmentation of patient clinical images for double-layered chip alignment for the full lumen chips, and identifying key area of thrombus development and pattern in various patient vessel geometries.
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