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Vaccine development and immunisation

Ensuring vaccine effectiveness
  • https://www.sydney.edu.au/infectious-diseases-institute/our-research.html Our research
  • https://www.sydney.edu.au/medicine-health/industry-and-community/support-us.html Support us

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Vaccines remain the most cost efficient way to prevent and control infectious diseases. Our research covers basic immunology, vaccine development, policy guidance and vaccine uptake.

Themes

Protective immunity

Protective immunity refers to the immune system's ability to recognise and effectively respond to a pathogen following vaccination, preventing disease or reducing its severity.

It is the ultimate goal of vaccination, as it ensures long-term defence against specific infections.

Understanding the mechanisms and durability of protective immunity is essential for designing vaccines that provide robust and lasting protection against diseases.

  • Complementary studies of HIV and Herpes Simplex Viral infection of genital mucosa and the mechanism of action of systemically delivered vaccines
  • Further development of the interferon-CAR T cell strategy for reducing latent HIV infection

Development and testing

Our world-leading experts develop and test vaccines against the most threatening bacterial and viral infections including tuberculosis (TB), SARS CoV-2, herpesviruses, influenza and HIV.

  • Adjuvanted Trimeric Spike Vaccine
  • Advancing Vaccine Adjuvant Research for Tuberculosis (AVART)
  • Nasal delivered COVID vaccine to block transmission of SARS-CoV-2
  • Policy-relevant research relating to the COVID-19 vaccine roll-out governed by a Research Grant Agreement between the Health Administration Corporation as represented by the Ministry of Health
  • Phase 2 clinical study for a next-generation, needle-free COVID-19 vaccine - Vaxxas Pty Ltd

Immunisation policy and practice

We use the best available evidence to guide national and regional vaccine programs. We also track vaccine safety and perform vaccine preventable disease surveillance.

  • Vaccine effectiveness against Omicron SARS-CoV-2 variant in NSW using linked data
  • Monitoring and Investigating the Safety and Effectiveness of The Covid-19 Vaccination Program

Vaccine hesitancy and immunisation uptake

Our social and behavioural researchers look at ways to reduce vaccine hesitancy and develop programs to improve vaccine uptake and coverage.

  • Optimising youth-centred health communication via social media during COVID-19 and beyond
  • Behavioural and social science to close gaps in vaccination coverage
  • Assess the future needs of Australia's aquatic animal disease diagnostic system
  • Integrating social science evidence into the fight against vaccine-preventable and vector-borne diseases in the Australasian, South East Asian and Pacific regions

Contact us

Mailing address
Westmead Hospital
Level 5, Block K 
Westmead NSW 2145