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Infrastructure_

Magnetic resonance spectroscopy

Specialised capabilities in nuclear magnetic resonance and electron paramagnetic resonance spectroscopies.
The magnetic resonance facility at Sydney Analytical supports research through 24/7 access to molecular and structural characterisation, biomolecular dynamic investigations and drug development studies.

Magnetic resonance spectroscopic methods measure the emission and absorption of energies of systems within strong magnetic fields. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful techniques available to probe molecular structure and characterise complex dynamic systems, and utilises the behaviour of atomic nuclei within strong magnetic fields when irradiated with radiofrequency energy. Electron Paramagnetic Resonance (EPR) spectroscopy is analogous to NMR, but probes the response of electron spins rather than nuclear spins, and is especially useful when investigating systems that contain free radicals or are paramagnetic. Both techniques are non-destructive and can be applied to complex systems with as little as nanogram amounts of material.

Magnetic resonance capabilities

This flagship high-field, narrow-bore, 3 channel NMR spectrometer is equipped with a high-resolution cryogenic triple nucleus probehead (H/C/N) providing significant signal-to-noise advantages over room temperature probes. The TCI probe can handle standard 3mm and 5mm tubes, as well as shaped tubes for high salt content samples. This spectrometer is optimised for the study of complex biomolecular systems, and provides capability for small molecule characterisation where only very limited amounts of samples are available.

A narrow-bore, 3-channel NMR spectrometer equipped with a high-resolution cryogenic triple nucleus probehead (H/C/N). Equipped with a high-throughput autosampler with individual rack temperature control, this system is ideal for metabolomic studies and fragment-based drug development, and supports commonly published metabolomic protocols. It is also ideally suited for the study of biomolecular systems, routine molecular and structural characterisation and drug screening studies

A narrow-bore, 3-channel NMR spectrometer running a 5mm multinuclear probehead and a 1.7mm microprobe for improved sensitivity. This instrument is supported by a high-throughput autosampler, has controlled variable temperature capacity between 180K and 350K and is utilised for small -medium molecule characterisation and structure elucidation, and is optimised for quantitative sample measurements to provide excellent screening for sample purity and QC/QA applications.

A narrow-bore, 3-channel NMR spectrometer running a 5mm multinuclear probehead and several triple nucleus probeheads that allow the investigation of specific nuclear combinations. This instrument is supported by a high-throughput autosampler and has controlled variable temperature capacity between 180K and 370K. It is utilised for small -medium molecule characterisation and structure elucidation, investigating molecular dynamics and ligand binding studies. Commonly observed heteronuclei include 2H, 19F, 11B, 13C, 15N, 17O, 19F, 29Si, 31P, 77Se, 119Sn and 195Pt.

A 400-MHz wide-bore NMR spectrometer equipped with a mini 0.5 micro-imaging system, a high-field gradient (1000 G/cm) diffusion probe, a Doty variable angle spinning probe, and several solution probes including 19F, broadband, dual and triple-resonance (H/C/N) probes. Depending on the probe, this system can handle samples in 5mm and 10mm tubes.

This 2-channel solution state instrument equipped with a 5mm multinuclear probehead (19F-15N) provides 24/7 walk up access to routine multinuclear acquisition, and is supported by a 24-sample autosampler, and variable temperature capability within the range of 180K and 350K.

This 2-channel solution state instrument supports a dual probe (H/C) for walk up rapid turnaround of basic sample screening and reaction monitoring. This instrument can support variable temperature experiments between 180K and 370K.

This modern benchtop EPR instrument has a field range of 0 to 6.5kG and delivers excellent sensitivity and stability for a range of research applications. It is equipped with a variable temperature accessory that allows operation in the range of 100K to 425K.

Chemistry Building (F11)

Molecular Bioscience Building (G08)