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EFFECTS OF TYPE I INTERFERONS IN CHRONIC VIRAL INFECTIONS

When type I interferon signalling is impaired, infection with lymphocytic choriomeningitis virus results in chronic infection and dysfunctional CD8+ T cell function. Investigate how more...

Supervisor(s): Hofer, Markus (Dr)

TARGETING THE BRAIN VASCULATURE AS A TREATMENT FOR CEREBRAL TYPE I INTERFERONOPATHIES

Abnormal blood vessels are feature of cerebral type I interferonopathies. Discover how the endothelial cells that line the brain’s blood vessels contribute to disease in patie more...

Supervisor(s): Hofer, Markus (Dr)

The nutritional geometry of non-alcoholic fatty liver disease, cardio-metabolic health and lifespan

The global epidemic of obesity and type 2 diabetes (T2D) has been linked to increased consumption of ‘western diets’ containing an abundance of processed foods rich in s more...

Supervisor(s): Simpson, Stephen (Professor), Wali, Jibran (Dr)

THE PATHOGENIC AND PROTECTIVE EFFECTS OF MICROGLIA IN CEREBRAL CYTOKINOPATHIES

Microglia are the primary immune cells of the brain and have the potential to both protect and contribute to neurological disease. Explore the molecular mechanisms that microglia us more...

Supervisor(s): Hofer, Markus (Dr)

HOW DIFFERENT CELL TYPES OF THE BRAIN CONTRIBUTE TO CEREBRAL CYTOKINOPATHIES

The brain consists of a large number of different cell types, including neurons, astrocytes, oligodendrocytes, microglia and endothelial cells. Discover how these different cell typ more...

Supervisor(s): Hofer, Markus (Dr)

Community based study of health effects of infrasound

A team of investigators at the Woolcock Institute have been funded by the NHMRC to evaluate any health effects associated with wind turbine simulated infrasound. Infrasound is belo more...

Supervisor(s): Toelle, Brett (Dr)

Precision medicines for GABA-A receptor variants in epilepsy

Developmental and Epileptic Encephalopathies (DEEs) are rare and severe neurological conditions often associated with intellectual disability, developmental delay, autism spectrum d more...

Supervisor(s): Collins, Mary (Professor)

GENE THERAPY FOR GENETIC BONE DISEASES

Gene therapy is becoming a practical approach to treat severe genetic conditions and in recent years conditions such as Spinal Muscular Atrophy (SMA) have been success stories. Our more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

PRECLINICAL AND CLINICAL DEVELOPMENT OF NOVEL BONE-BINDING ANTIMICROBIALS

Our team has spent several years developing and testing new a new class of drugs termed bone-binding antimicrobials (BBAs). Our lead compound (BBA-1) has been shown to have antimicr more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Little, David (Professor)

Molecular insights into a novel mammalian oxygen-sensing pathway

Oxygen (O2) is a vital biological resource most prominently known for its role as the final electron acceptor in aerobic respiration and, as such, adequate molecular mechanisms are more...

Supervisor(s): White, Mark (Dr), Mackay, Joel (Professor)