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Mechanism of the effect of diabetes on the inflammation and subsequent fibrosis

In our laboratory we are investigating the effects of diabetes on the inflammatory response and the initiation of fibrosis and the relationship between these changes and the develop more...

Supervisor(s): McLennan, Susan (Dr)

Dietary effects to the local immune response and the initiation and propagation of diabetes and cardiovascular disease in mice

Background: Longitudinal studies have demonstrated a two-¬way relationship between diabetes and the local inflammatory host response, e.g. periodontitis, with more severe period more...

Supervisor(s): Eberhard, Joerg (Professor)

Regulation of host resistance and immune response to human pathogens

The laboratory of Immunology and Host Defense focuses on the immune mechanisms that regulate host resistance to pathogens of global importance. It currently offers multiple projects more...

Supervisor(s): Feng, Carl (Dr)

Influencing anti-inflammatory functions of monocytes by targeting the haemoglobin scavenger receptor CD163: possible role in the development of diabetes complications

This project addresses the problem of how causes of diabetes complications, specifically the effect of diabetes on the regulation of one of these anti-inflammatory cell surface prot more...

Supervisor(s): Min, Danqing (Dr), McLennan, Susan (Dr), Twigg, Stephen (Professor)

Computational Modeling of Immune Cell Chemotaxis and Swarming

 Using computational simulation to form and evaluate hypotheses concerning the factors that drive immune cell motility, such as neutrophil swarming, during inflammation. more...

Supervisor(s): Read, Mark (Dr)

Nutrient regulation of the stem cell compartment

Australia is among the countries with the fastest growing rates of overweight and obesity, which by 2025 will affect >70% of the population. Chronic diseases linked to obesity in more...

Supervisor(s): George, Jacob (Professor)

Immuno-metabolism of macrophages in inflammatory diseases

In metabolic organs like the liver and fat, macrophage infiltration plays a pivotal role in driving low-grade chronic inflammation that results in many of the consequences of obesi more...

Supervisor(s): George, Jacob (Professor)

Factors affecting oral health in cerebral palsy patients: dental caries experience, microbiome and oral health related quality of life (OHRQoL)

Cerebral palsy (CP) is a set of nonprogressive neuromuscular disorders caused by defects in the developing fetal brain. Children with Cerebral Palsy are often have physical, coordin more...

Supervisor(s): Akhter, Rahena (Dr)

The HAMLET molecular species with anticancer properties

We are interested to determine how the anti-cancer properties of this family of molecules can be translated into cancer treatment. We believe there may be a delivery system which n more...

Supervisor(s): Church, W Bret (Dr)

• Roles of matrix metalloproteinases (MMPs), E-cadherin, beta-catenin, transforming growth factor (TGF-beta), epithelial & endothelial –mesenchymal transition in pathogenesis of kidney fibrosis.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)