Our research focuses on growth factors because of their importance in regulating cell fates in developmental and pathological systems.

To maintain lens integrity and transparency for optimal vision, we need to better understand the intricate intracellular growth factor signalling pathways responsible for lens cell activity.

For example, the role of MAP kinases, which are key for lens cell proliferation, differentiation and pathology. How their activity is precisely regulated is fundamental to a healthy functional lens.

Insights into the molecular basis of cataract have arisen from our growth factor studies. We have shown that members of the transforming growth factor beta (TGFß) family induce aberrant growth and differentiation of lens epithelial cells, similar to a wound healing response. This progressively leads to disruption of normal cellular architecture and lens opacification.

Because of its clinical significance, it is vital to understand how TGFß is regulated in the eye and how it induces cataractous effects on the lens. This information is fundamental to understanding the molecular basis of cataract and devising strategies for prevention.

We are also working towards devising strategies that could be used to promote normal differentiation and or maintenance of lens epithelial cells after cataract surgery.

We have started to better characterise the constituents of the lens basement membrane and show its importance for lens cells.

We are working to elucidate the molecular basis of all these interactions, and the signalling pathways involved, as we feel this will provide the key to promoting normal lens cell behaviour and function after cataract surgery.