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Utility of Cerebrospinal fluid proteomics to define molecular mechanisms in brain disease of childhood.

Brain diseases of childhood are very common and result in significant disability, and cost to the nation. Common diseases include epilepsy, cerebral palsy, autism and mental health more...

Supervisor(s): Dale, Russell (Professor)

Understanding disease progression and comorbidities using multi-omics and clinical information

This research project aims at exploring clinical and multi-omics data to improve our present understanding of disease progression, transition and comorbidities. To achieve this aim, more...

Supervisor(s): Uddin, Shahadat (Dr)

Impact of chronic inflammation on bowel and sexual function

Inflammatory bowel diseases (IBD) is difficult to treat and secondary pathological outcome can include decreased fertility. Also, many of the available treatments cause unwanted se more...

Supervisor(s): Witting, Paul (Dr)

Characterising changes in a proteome of islets and islet cell types during progression to type 2 diabetes

Characterizing changes in a proteome through pathogenesis of diseases can provide unparalleled insights into the mechanisms underpinning disease. In this project, using flow cytomet more...

Supervisor(s): Kebede, Melkam (Dr)

Design and synthesis of selective anion receptors to facilitate transmembrane anion transport in epithelial cells

CF is a recessive genetic condition that results from the dysregulation of anion transport through the cystic fibrosis transmembrane regulator anion channel in epithelial cell membr more...

Supervisor(s): Gale, Philip (Professor)

Control of complement cascade by labile disulphide bonds

The complement system is a key component of innate immunity that offers sophisticated protection against threats to the host organism. Complement is also an important component of t more...

Supervisor(s): Chiu, Joyce (Dr)

Sleep and circadian health

Several research opportunities are available, all of which revolve around the new and emerging areas of sleep and circadian epidemiology. The overarching aim of these projects is to more...

Supervisor(s): Bin, Yu Sun (Dr)

Maternal autoimmunity increases risk of neurodevelopmental problems in offspring.

Maternal autoimmunity is a recognised risk factor for autism and other neurodevelopmental and psychiatric disorders in the offspring. It is well established in humans and animal mod more...

Supervisor(s): Dale, Russell (Professor), Hofer, Markus (Dr)

Computational approaches to elucidate Multiple Sclerosis and Contact Dermatitis pathogenesis, and its treatment through ultraviolet light exposure

Allergies and autoimmunity are complex immune system aberrations. Both involve multiple immune cell populations coordinating across several organs of the body. The growing prevalenc more...

Supervisor(s): Read, Mark (Dr)

Respiratory syncytial virus in Australia: Molecular Epidemiology and Evolution

This project aims to better understand the molecular epidemiology and evolution of respiratory syncytial virus (RSV) in Australia using whole-genome sequencing and phylogenetic appr more...

Supervisor(s): Eden, John-Sebastian (Dr)