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Gene editing of stem cells or cancer to develop new stem cell therapies to treat human disease

This project involves the use of human stem cells and CRISPR genome editing to study basic signalling pathways controlling stem cell differentiation and/or cancer. A compliment more...

Supervisor(s): Neely, Greg (Professor)

THE PATHOGENIC AND PROTECTIVE EFFECTS OF MICROGLIA IN CEREBRAL CYTOKINOPATHIES

Microglia are the primary immune cells of the brain and have the potential to both protect and contribute to neurological disease. Explore the molecular mechanisms that microglia us more...

Supervisor(s): Hofer, Markus (Dr)

Pain Phenotype Characterisation in Preclinical Models of Osteoarthritis

Osteoarthritis (OA) is the most common chronic joint disease, affecting 15% of the population and causing a significant socioeconomic burden. It is a debilitating condition characte more...

Supervisor(s): Zaki, Sanaa (Dr)

Conserved Regulatory Genes in Neurodevelopment

The present project aims to utilize the promising combination of 3D organoid technology and CRISPR genome editing, which will allow us to examine the roles of several conserved gene more...

Supervisor(s): Neely, Greg (Professor)

Will a novel form of oral peanut immunotherapy induce regulatory immune responses and modify the gastrointestinal microbiome ?

In this part of the study, we will investigate the immunological mechanisms involved in the desensitization process. This will include the effects of short chained fatty acids in th more...

Supervisor(s): Nanan, Ralph (Professor)

Molecular insights into a novel mammalian oxygen-sensing pathway

Oxygen (O2) is a vital biological resource most prominently known for its role as the final electron acceptor in aerobic respiration and, as such, adequate molecular mechanisms are more...

Supervisor(s): White, Mark (Dr), Mackay, Joel (Professor)

Novel metrics to quantify patterns of medication use in asthma

This project explores patterns of medication usage and adherence and their relationship with clinical outcomes in asthma, using novel metrics to describe patterns over time. more...

Supervisor(s): Thamrin, Cindy (Dr), Reddel, Helen (Professor)

Microscale Technology and 3D Printing for Therapeutic Delivery and Tissue Engineering

Dr. Kang is working in the area of drug delivery / testing and tissue engineering by using micro- and nano- scale technologies.For drug delivery, several drug-device combination pro more...

Supervisor(s): Kang, Lifeng (Dr)

HOW DIFFERENT CELL TYPES OF THE BRAIN CONTRIBUTE TO CEREBRAL CYTOKINOPATHIES

The brain consists of a large number of different cell types, including neurons, astrocytes, oligodendrocytes, microglia and endothelial cells. Discover how these different cell typ more...

Supervisor(s): Hofer, Markus (Dr)

“Local Sleep” in the Awake Brain: An Underlying Cause of Neurobehavioural Deficits in Obstructive Sleep Apnea?

Snorers who are easily distracted and struggle to focus on the job might have a new culprit to blame: Napping neurons. We are investigating why so many of the nation’s snore more...

Supervisor(s): D’Rozario, Angela (Dr)